【Press Release】Immune Cell–Fibroblast Crosstalk May Be the Key Trigger of Autoimmune Diseases

Researchers reveal a fundamental disease-amplifying cellular interaction between immune cells and fibroblasts drives Sjögren disease progression
 
Sjögren disease, an autoimmune disease characterized by dry mouth and dry eyes, may reduce patients’ quality of life. While CD4+ T cells are key drivers of immune-mediated tissue damage and chronic inflammation, the role of pathogenic CD4+ T cell subsets and their non-immune cell partners remains unexplored. Researchers have now identified the preferential CD4+ T cell-fibroblast cellular interaction that amplifies inflammatory proteins and tissue damage, representing a potential target for therapeutic intervention in Sjögren disease.

 Communication between T cells and fibroblasts drives progression of Sjögren disease