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| 2026 | • |
Acid-Mediated Synthesis of Unsymmetrical Trisulfides via a Sulfur-Elongation Strategy |
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Catalyst-Controlled Regioselectivity Switching in the Bromolactonization of Z-Stilbenecarboxylic Acids |
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Assessment of Solvation Models for Quantum Chemistry Calculations through A-Value Determination and Conformational Equilibrium Analysis of Difluorocyclohexanes as Benchmark Systems |
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Asymmetric Mannich Reaction of ɑ-(2-Nitrophenylsulfenyl)imino Acetamide: A Cyclization-driven Process |
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Alkyl and Aryl Thioester Synthesis via N-Heterocyclic Carbene-Catalyzed α-Thio Aldehyde Rearrangement. |
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| • | Palladium-Catalyzed Asymmetric Arylation of α-2-Nitrophenylsulfenylimino Acetamide Inokuma, T.; Fukuhara, K.; Sugano, M.; Someno, T.; Yamada, K. Tetrahedron 2026, 190 (15), 135041.  |
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| 2025 | • | A Potassium Base-Promoted Intramolecular EnolateOlefin Metathesis. Sugimoto, K.;Nagao, T.; Kurokawa, K.; Tawatari, T.; Miyakawa, Y.; Fujimura, S.; Yamada, K.; Yamaoka, Y.; Kohyama, A.; Kuroda, Y.; Takikawa, H.; Takasu K. Chem. Eur. J. 2025, 31 (55), e00737.  |
| • | Diastereodivergent Construction of Octahydrophenanthridinone and Octahydrophenanthridine Cores Sun, C.; Nishikawa, H.; Inokuma, T.; Yamada, K. Molecules 2025, 30 (2), 371.  |
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| 2024 | • | Improvement of Asymmetric Reactions via Remote Electronic Tuning of N-Heterocyclic Carbene Catalysts Inokuma, T.; Yamada, K. ChemCatChem 2024, 16 (22), e202401078.  |
| • | Total Synthesis of 1,4a-di-epi-ent-Pancratistatin, Exemplifying a Stereodivergent Approach to Pancratistatin Isomers Sun, C.; Inokuma, T.; Tsuji, D.; Yamaoka, Y.; Akagi, R.; Yamada, K. Chem. Commun. 2024, 60 (53), 6757-6760.  |
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| • | 遠隔位電子チューニングによるN-複素環式カルベン触媒の高性能化 猪熊 翼, 山田 健一 J. Synth. Org. Chem. Jpn. 2024, 82 (3), 222-233. |
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| • | 5-exo-Selective Asymmetric Bromolactonization of Stilbenecarboxylic Acids Catalyzed by Phenol-bearing Chiral Thiourea. Sugano, M.; Inokuma, T.; Yamaoka, Y.; Yamada, K. Org. Biomol. Chem. 2024, 22 (9), 1765-1769.   |
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| 2023 | • | Evaluation of Quantum Chemistry Calculation Methods for Conformational Analysis of Organic Molecules Using A-Value Estimation as a Benchmark Test. Yamada, K.; Inokuma, T. RSC Adv. 2023, 13 (51), 35904-35910.  |
| • | Remote Electronic Tuning of Chiral N-Heterocyclic Carbenes. Inokuma, T.; Yamada, K. Chem. Rec. 2023, 23 (7), Special Issue: Organocatalysis, e202300103.  |
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| • | Remote Electronic Effect of Chiral N-Heterocyclic Carbene Catalyst on an Asymmetric Benzoin Reaction. Inokuma, T.; Hashimoto, K.; Fujiwara, T.; Sun, C.; Kuwano, S.; Yamada, K. Chem. -Eur. J. 2023, 29 (38), e202300858.  |
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| • | Remote Electronic Effect on the N-Heterocyclic Carbene-catalyzed Asymmetric Intramolecular Stetter Reaction and Structural Revision of Products. Inokuma, T.; Iritani, K.; Takahara, Y.; Sun, C.; Yamaoka, Y.; Kuwano, S.; Yamada, K. Chem. Commun. 2023, 59 (36), 5375-5378. (Selected as a front cover art of Chem. Commun. 2023, 59 (36))   |
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| • | Preparation of N-2-Nitrophenylsulfenyl Imino Peptides and Their Catalyst-Controlled Diastereoselective Indolylation. Inokuma, T.; Masui, K.; Fukuhara, K.; Yamada, K. Chem. -Eur. J. 2023, 29 (8), e202203120. (Highlighted in Synfacts 2023, 19 (02), 207.)  |
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| 2022 | • | Kinetic Resolution of α-Hydroxyamide via N-Heterocyclic Carbene-Catalyzed Acylation. Yamada, K.; Yamauchi, A.; Fujiwara, T.; Hashimoto, K.; Wang, Y.; Kuwano, S.; Inokuma, T. Asian J. Org. Chem. 2022, 11 (10), e202200452. |
| • | Enhanced Molecular Recognition through SubstrateAdditive Complex Formation in N-Heterocyclic-Carbene-Catalyzed Kinetic Resolution of α-Hydroxythioamides. Wang, Y.; Yamauchi, A.; Hashimoto, K.; Fujiwara, T.; Inokuma, T.; Mitani, Y.; Ute, K.; Kuwano, S.; Yamaoka, Y.; Takasu, K.; Yamada, K. ACS Catal. 2022, 12 (10), 6100–6107. |
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| 2021 | • | The Rationale for Stereoinduction in Conjugate Addition to Alkylidenemalonates Bearing a Menthol-derived Chiral Auxiliary. Yamada, K.; Fujiwara, S.; Inokuma, T.; Sugano, M.; Yamaoka, Y.; Takasu, K. Tetrahedron 2021, 91, 132220.  |
| • | Mechanistic Support for Intramolecular Migrative Cyclization of Propargyl Sulfones Provided by Catalytic Asymmetric Induction with a Chiral Counter Cation Strategy. Yamasaki, K.; Yamauchi, A.; Inokuma, T.; Miyakawa, Y.; Wang, Y.; Oriez, R.; Yamaoka, Y.; Takasu, K.; Tanaka, N.; Kashiwada, Y.; Yamada, K. Asian J. Org. Chem. 2021, 10 (7), 1828–1834.  |
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| • | Synthesis of Non-canonical Amino Acids and Peptide Containing Them for Establishment of the Template for Drug Discovery Inokuma, T. Chem. Pharm. Bull. 2021, 69 (4), 303–313.  |
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| 2020 | • | Helical Nanographenes Embedded with Contiguous Azulene Units. Ogawa, N.; Yamaoka, Y.; Takikawa, H.; Yamada, K.; Takasu, K. J. Am. Chem. Soc. 2020, 142 (31), 13322–13327.  |
| • | Cloning and Expression of a Perilla frutescens Cytochrome P450 Enzyme Catalyzing the Hydroxylation of Phenylpropenes. Baba, M.; Yamada, K.; Ito, M. Plants 2020, 9 (5), 577. |
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| • | Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent. Nakayama, A.; Otani, A.; Inokuma, T.; Tsuji D.; Mukaiyama, H.; Nakayama, A.; Itoh, K.; Otaka, A.; Namba, K. Commun. Chem. 2020, 3, 6. |
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| 2019 | • | Asymmetric Synthesis of α-Amino Phosphonic Acids Using Stable Imino Phosphonate as a Universal Precursor. Tsubasa Inokuma, Takuya Sakakibara, Takatoshi Someno, Kana Masui, Akira Shigenaga, Akira Otaka, and Ken-ichi Yamada Chem. -Eur. J. 2019, 25 (60), 13829–13832.  |
| • | Total Syntheses of Allelopathic 4-Oxyprotoilludanes, Melleolides and Echinocidins. Shimoda, K.; Yamaoka, Y.; Yoo, D.; Yamada, K.; Takikawa, H.; Takasu, K. J. Org. Chem. 2019, 84 (17), 11014–11024.  |
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| • | Synthesis of Functionalized Medium-Sized trans-Cycloalkenes by 4π Electrocyclic Ring Opening–Alkylation Cascade. Takasu, K.; Ito, T.; Tsutsumi, M.; Yamada, K.; Takikawa, H.; Yamaoka, Y. Angew. Chem. Int. Ed. 2019, 58 (34), 11836–11840.  |
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| • | Rapid Assembly of Protoilludane Skeleton through Tandem Catalysis: Total Synthesis of Paesslerin A and Its Structural Revision. Mogi, Y.; Inanaga, K.; Tokuyama, H.; Ihara, M.; Yamaoka, Y.; Yamada, K.; Takasu, K. Org. Lett. 2019, 21 (11), 3954–3958.  |
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| • | Asymmetric Formal Synthesis of (+)-Catharanthine via Desymmetrization of Isoquinuclidine. Kono, M.; Harada, S.; Nozaki, T.; Hashimoto, Y.; Murata, S.; Gröger, H.; Kuroda, Y.; Yamada, K.; Takasu, K.; Hamada, Y.; Nemoto, T. Org. Lett. 2019, 21 (10), 3750–3754.  |
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| • | Optical Resolution via Catalytic Generation of Chiral Auxiliary. Hiroki Kiyama, Tsubasa Inokuma, Yusuke Kuroda, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada, Tetrahedron Lett. 2019, 60 (2), 175–177.  |
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| 2018 | • | ペプチドへの直接的不斉反応を基盤とした非天然アミノ酸含有ペプチドの新規効率的不斉合成法開発. 猪熊 翼 Yakugaku Zasshi 2018 , 138 (11), 1371–1379. |
| • | Aminolithiation–Arylation Consecutive Cyclization of N-(2-Fluorophenyl)methyl-aminoalkylstyryls Giving Aryl-substituted Pyrido[1,2-b]isoquinoline. Yamamoto, Y.; Nakanishi, Y.; Yamada, K.; Tomioka, K. Tetrahedron 2018, 74 (38), 5309–5318.  |
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| • | A Recyclable Hydrophobic Anchor-Tagged Asymmetric Amino Thiourea Catalyst. Takahisa Jichu, Tsubasa Inokuma, Keisuke Aihara, Taiki Kohiki, Kodai Nishida, Akira Shigenaga, Ken-ichi Yamada, and Akira Otaka, ChemCatChem 2018, 10 (16), 3402–3405.  |
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| • | Direct Enantioselective Indolylation of Peptidyl Imine for the Synthesis of Indolyl Glycine-Containing Peptides. Tsubasa Inokuma, Kodai Nishida, Akira Shigenaga, Ken-ichi Yamada, and Akira Otaka, Heterocycles 2018, 97 (2), 1269–1287.  |
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| • | 薬学における生命指向型化学(実用的ケミカルバイオテクノロジーの開発を目指して). 猪熊 翼、佐藤 伸一, Yakugaku Zasshi 2018, 138 (1), 37–38. |
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| 2017 | • | A Convenient Method for Preparation of α-Imino Carboxylic Acid Derivatives and Application to the Asymmetric Synthesis of Unnatural α-Amino Acid Derivative. Tsubasa Inokuma, Takahisa Jichu, Kodai Nishida, Akira Shigenaga, and Akira Otaka, Chem. Pharm. Bull. 2017, 65 (6), 573–581. Highlighted paper selected by Editor-in-Chief |
| • | Consecutive Aminolithiation–Carbolithiation of a Linear Aminoalkene Bearing Terminal Vinyl Sulfide Moiety to Give Hydroindolizine. Yamamoto, Y.; Yamaguchi, T.; Kaneshige, A.; Hashimoto, A.; Kaibe, S.; Miyawaki, A.; Yamada, K.; Tomioka, K. Synlett 2017, 28 (20), 2913–2917. |
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| • | Synthesis of Multi-Substituted Cyclobutenes: Cyclic Strategy for [2+2] Cycloadditon of Ketene Silyl Acetals with Propiolates. Yamaoka, Y.; Ueda, M.; Yamashita, T.; Shimoda, K.; Yamada, K.; Takasu, K. Tetrahedron Lett. 2017, 58 (30), 2944–2947.  |
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| • | Synthesis of π-Extended Fluoranthenes via a KHMDS-promoted Anionic-Radical Reaction Cascade. Ogawa, N.; Yamaoka, Y.; Yamada, K.; Takasu, K. Org. Lett. 2017, 19 (12), 3327–3330.  |
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| • | Synthesis and Biological Evaluation of Steroidal Derivatives Bearing a Small Ring as Vitamin D Receptor Agonists. Arichi, N.; Fujiwara, S.; Ishizawa, M.; Makishima, M.; Hua, D. H.; Yamada, K.; Yamaoka, Y.; Takasu, K. Bioorg. Med. Chem. Lett. 2017, 27 (15), 3408–3411.  |
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| • | Site-selective Benzoin-type Cyclization of Unsymmetrical Dialdoses Catalyzed by N-Heterocyclic Carbenes for Divergent Cyclitol Synthesis. Bubwoong Kang, Yinli Wang, Satoru Kuwano, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada, Chem. Commun. 2017, 53 (32), 4469–4472.  |
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| • | Phosphine-Promoted Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide for the Synthesis of Oxa- and Azacycles. Yinli Wang, Raphaël Oriez, Shogun Oh, Yasunori Miyakawa, Yousuke Yamaoka, Kiyosei Takasu, and Ken-ichi Yamada, Heterocycles 2017, 95 (Special Issue), 314–321.  |
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| 2016 | • | Use of a Catalytic Chiral Leaving Group for Asymmetric Substitutions at sp3-Hybridized Carbon Atoms: Kinetic Resolution of β-Amino Alcohols byp-Methoxybenzylation. Yusuke Kuroda, Shingo Harada, Akinori Oonishi, Hiroki Kiyama, Yousuke Yamaoka, Ken-ichi Yamada, and Kiyosei Takasu, Angew. Chem. Int. Ed. 2016, 55 (42), 13137–13141.  |
| • | Desymmetrization of Acid Anhydride with Asymmetric Esterification Catalyzed by Chiral Phosphoric Acid. Ken-ichi Yamada, Akinori Oonishi, Yusuke Kuroda, Shingo Harada, Hiroki Kiyama, Yousuke Yamaoka, and Kiyosei Takasu, Tetrahedron Lett. 2016, 57 (36), 4098–4100.  |
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| • | Striking Difference between Succinimidomethyl and Phthalimidomethyl Radicals in Conjugate Addition to Alkylidenemalonate Initiated by Dimethylzinc. Yamada, K.; Matsumoto, Y.; Fujii, S.; Konishi, T.; Yamaoka, Y.; Takasu, K. J. Org. Chem. 2016, 81 (9), 3809–3817.  |
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| • | Oxa- and Azacycle-formation via Migrative Cyclization of Sulfonylalkynol and Sulfonylalkynamide with N-Heterocyclic Carbene. Wang, Y.; Oriez, R.; Kuwano, S.; Yamaoka, Y.; Takasu, K.; Yamada, K. J. Org. Chem. 2016, 81 (6), 2652–2664.  |
