2021年

Doxorubicin Embedded into Nanofibrillated Bacterial Cellulose (NFBC) Produces a Promising Therapeutic Outcome for Peritoneally Metastatic Gastric Cancer in Mice Models via Intraperitoneal Direct Injection
Hidenori Ando, Takashi Mochizuki, Amr S. Abu Lila, Shunsuke Akagi, Kenji Tajima, Kenji Fujita, Taro Shimizu, Yu Ishima, Tokuo Matsushima, Takatomo Kusano, Tatsuhiro Ishida
Nanomaterials, 2021, 11, 1697 [DOI: 10.3390/nano11071697]

Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice
Sherif E. Emam, Nehal E. Elsadek, Amr S. Abu Lila, Haruka Takata, Yoshino Kawaguchi, Taro Shimizu, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
J. Control. Release, 2021, 334, 327-334 [DOI: 10.1016/j.jconrel.2021.05.001]

Incorporating gangliosides into PEGylated cationic liposomes that complexed DNA attenuates anti-PEG antibody production, but not anti-DNA antibody production in mice
Milad Reda Qelliny, Taro Shimizu, Nehal E. Elsadek, Sherif E. Emam, Haruka Takata, Zeinab M. A. Fathalla, Amal K. Hussein, Khaled A. Khaled, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
Mol. Pharmaceut., 2021, 18, 2406-2415 [DOI: 10.1021/acs.molpharmaceut.1c00255]

Evidence for delivery of Abraxane® via a denatured-albumin transport system
Maichi Hama, Yu Ishima, Victor Tuan Giam Chuang, Hidenori Ando, Taro Shimizu, Tatsuhiro Ishida
ACS Applied Materials & Interfaces, 2021, 13, 19736-19744 [DOI: 10.1021/acsami.1c03065]

Reduction-responsive and Multi-drug Deliverable Albumin Nanoparticles: an antitumor drug to Abraxane® against Human Pancreatic Tumor-Bearing Mice
Naoki Hirakawa, Yu Ishima, Ryo Kinoshita, Ryuto Nakano, Victor Tuan Giam Chuang, Hidenori Ando, Taro Shimizu, Keiichiro Okuhira, Toru Maruyama, Masaki Otagiri, and Tatsuhiro Ishida
ACS Applied Bio Materials, 2021, 4, 4302-4309 [DOI: 10.1021/acsabm.1c00110]

Nucleic acids delivered by PEGylated cationic liposomes in systemic lupus erythematosus-prone mice: a possible exacerbation of lupus nephritis in the presence of pre-existing anti-nucleic acid antibodies
Haruka Takata, Taro Shimizu, Yoshino Kawaguchi, Hiro Ueda, Nehal E. Elsadek, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
Int. J. Pharm., 2021, 601, 120529 [DOI: 10.1016/j.ijpharm.2021.120529]

Therapeutic efficacy of a paclitaxel-loaded nanofibrillated bacterial cellulose (PTX/NFBC) formulation in a peritoneally disseminated gastric cancer xenograft model
Shunsuke Akagi, Hidenori Ando, Kenji Fujita, Taro Shimizu, Yu Ishima, Kenji Tajima, Tokuo Matsushima, Takatomo Kusano, Tatsuhiro Ishida
Int. J. Biol. Macromol., 2021, 174, 494-501 [DOI: 10.1016/j.ijbiomac.2021.01.201]

Lymphoid follicle antigen (Ag) delivery and enhanced rodent humoral immune responses mediated by Ag-containing PEGylated liposomes
Taro Shimizu, Yuki Watanabe, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
Vaccine, 2021, 39, 1131-1139 [DOI: 10.1016/j.vaccine.2021.01.008]

Complement activation induced by PEG enhances humoral immune responses against antigens encapsulated in PEG-modified liposomes
Taro Shimizu, Mizuki Awata, Amr S Abu Lila, Chihiro Yoshioka, Yoshino Kawaguchi, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
J. Control. Release, 2021, 329, 1046-1053 [DOI: 10.1016/j.jconrel.2020.10.033]

Suppression of Lipid Accumulation in 3T3-L1 Adipocytes by α-Tocopheryl Succinate
Dai Majima, Ryosuke Mitsuhashi, Misaki Yamasaki, Kazuaki Kajimoto, Tatsuya Fukuta, Kentaro Kogure
Biol. Pharm. Bull., 2021, 44, 46-50 [DOI: 10.1248/bpb.b20-00573]

富士山南東麓における水溶性酸性ガス及び粒子状物質に含まれる陰イオンのオンライン観測
竹内 政樹, 並川 誠, 岡本 和将, 小田 達也, 田中 遥, 大河内 博, 戸田 敬, 三浦 和彦, 田中 秀治
BUNSEKI KAGAKU, 2021, 70, 1.2, 65-69 [DOI: 10.2116/bunsekikagaku.70.65]

2020年

Quantification of Overlapped Peaks with Partial Least Squares Regression: Open Tubular Ion Chromatography for Sodium and Ammonium Ions
Yuta Otsuka, Hiroki Watanabe, Hideji Tanaka, Masaki Takeuchi
J. Flow Injection Anal., 2020, 37, 2, 73-77 [DOI: 10.24688/jfia.37.2_73]

Gene Expression of 4'-Thioguanine DNA via 4'-Thiocytosine RNA
Noriko S Tarashima, Ayako Matsuo, Noriaki Minakawa
J. Am. Chem. Soc., 2020, 142, 17255-17259 [DOI: 10.1021/jacs.0c07145]

Leukocyte-Mimetic Liposomes Penetrate Into Tumor Spheroids and Suppress Spheroid Growth by Encapsulated Doxorubicin
Tatsuya Fukuta, Shintaro Yoshimi, Kentaro Kogure
J. Pharm. Sci., 2020, S0022-3549, 30665-30661 [DOI: 10.1016/j.xphs.2020.10.049]

Noninvasive transdermal delivery of liposomes by weak electric current
Mahadi Hasan, Anowara Khatun, Tatsuya Fukuta, Kentaro Kogure
Adv. Drug Deliv. Rev., 2020, 154-155, 227-235 [DOI: 10.1016/j.addr.2020.06.016]

Utilization of Click Chemistry to Study the Effect of Poly(ethylene) Glycol Molecular Weight on the Self-Assembly of PEGylated Gambogic Acid Nanoparticles for the Treatment of Rheumatoid Arthritis
Anne Nguyen, Hidenori Ando, Roland Böttger, K K DurgaRao Viswanadham, Elham Rouhollahi, Tatsuhiro Ishida, Shyh-Dar Li
Biomater. Sci., 2020, 8, 4626-4637 [DOI: 10.1039/d0bm00711k]

Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon
Marwa Mohamed El Sayed, Haruka Takata, Taro Shimizu, Yoshino Kawaguchi, Amr S Abu Lila, Nehal E Elsadek, Eman Alaaeldin, Yu Ishima, Hidenori Ando, Amal Kamal, Hatem A Sarhan, Tatsuhiro Ishida
J. Control. Release, 2020, 323, 102-109 [DOI: 10.1016/j.jconrel.2020.04.011]

Weak Electric Current Treatment to Artificially Enhance Vascular Permeability in Embryonated Chicken Eggs
Tatsuya Fukuta, Natsu Nakatani, Shintaro Yoneda, Kentaro Kogure
Biol. Pharm. Bull., 2020, 43, 1729-1734 [DOI: 10.1248/bpb.b20-00423]

Isolation of glycosylinositol phosphoceramide and phytoceramide 1-phosphate in plants and their chemical stabilities
Rumana Yesmin Hasi, Dai Majima, Katsuya Morito, Hanif Ali, Kentaro Kogure, Meera Nanjundan, Junji Hayashi, Ryushi Kawakami, Kaori Kanemaru, Tamotsu Tanaka
Journal of Chromatography B, 2020, 1152, 122213 [DOI: 10.1016/j.jchromb.2020.122213]

Adjuvant antitumor immunity contributes to the overall antitumor effect of PEGylated liposomal doxorubicin (Doxil®) in C26 tumor-bearing immunocompetent mice
Takuma Takayama, Taro Shimizu, Amr S. Abu Lila, Yuki Kanazawa, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
Pharmaceutics, 2020, 12, 990 [DOI: 10.3390/pharmaceutics12100990]

Pegfilgrastim (PEG-G-CSF) induces anti-polyethylene glycol (PEG) IgM via a T cell- dependent mechanism
Nehal E. Elsadek, Sherif E. Emam, Amr S. Abu Lila, Taro Shimizu, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
Biol. Pharm. Bull., 2020, 43, 1393-1397 [DOI: 10.1248/bpb.b20-00345]

Protective effect of high-affinity liposomes encapsulating astaxanthin against corneal disorder in the in vivo rat dry eye disease model
Tatsuharu Shimokawa, Tatsuya Fukuta, Toshio Inagi, Kentaro Kogure
Journal of Clinical Biochemistry and Nutrition, 2020, 66, 3, 224-232 [DOI: 10.3164/jcbn.19-102]

Protective Effect of Antioxidative Liposomes Co-encapsulating Astaxanthin and Capsaicin on CCl4-Induced Liver Injury
Tatsuya Fukuta, Shota Hirai, Tatsusada Yoshida, Takashi Maoka, Kentaro Kogure
Biol. Pharm. Bull., 2020, 43, 1272-1274 [DOI: 10.1248/bpb.b20-00116]

Non-invasive delivery of biological macromolecular drugs into the skin by iontophoresis and its application to psoriasis treatment
Tatsuya Fukuta, Yasufumi Oshima, Kohki Michiue, Daichi Tanaka, Kentaro Kogure
Journal of Controlled Release, 2020, 323, 323-332 [DOI: 10.1016/j.jconrel.2020.04.044]

Impact of pre-existing or induced anti-PEG IgM on the pharmacokinetics of peginterferon alfa-2a (Pegasys®) in mice
Nehal E. Elsadek, Eri Hondo, Taro Shimizu, Haruka Takata, Amr S. Abu Lila, Sherif E. Emam, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
Mol. Pharmaceut., 2020, 17, 2964-2970 [DOI: 10.1021/acs.molpharmaceut.0c00366]

Low level electricity increases the secretion of extracellular vesicles from cultured cells
Tatsuya Fukuta, Akina Nishikawa, Kentaro Kogure
Biochemistry and Biophysics Reports, 2020, 21, 100713 [DOI: 10.1016/j.bbrep.2019.100713]

Pegfilgrastim (PEG-G-CSF) induces anti-PEG IgM in a dose dependent manner and causes the accelerated blood clearance (ABC) phenomenon upon repeated administration in mice
Nehal E. Elsadek, Amr S. Abu Lila, Sherif E. Emam, Taro Shimizu, Haruka Takata, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida
Eur. J. Pharm. Biopharm., 2020, 152, 56-62 [DOI: 10.1016/j.ejpb.2020.04.026]

A unique gene-silencing approach, using an intelligent RNA expression device (iRed), results in minimal immune stimulation when given by local intrapleural injection in malignant pleural mesothelioma
Hidenori Ando, Noriko Saito-Tarashima, Amr S. Abu Lila, Nozomi Kinjo, Taro Shimizu, Yu Ishima, Noriaki Minakawa, Tatsuhiro Ishida
Molecules, 2020, 25, 1725 [DOI: 10.3390/molecules25071725]

Synthesis and properties of oligonucleotides containing a 2,6-diamino-3-deazapurine:furanopyrimidine base pair
Koki Matsumoto, Noriko Saito-Tarashima, Tomoya Wada, Orie Yonaha, Noriaki Minakawa
Nucleosides Nucleotides Nucleic Acids, 2020, 1-18 [DOI: 10.1080/15257770.2019.1694687]

Enhancement of antioxidative activity of astaxanthin by combination with an antioxidant capable of forming intermolecular interactions
Tatsuya Fukuta, Shota Hirai, Tatsusada Yoshida, Takashi Maoka, Kentaro Kogure
Free Radical Research, 2020 [DOI: 10.1080/10715762.2019.1693042]

Characteristics of unique endocytosis induced by weak current for cytoplasmic drug delivery
Tasuku Torao, Miyuki Mimura, Yasufumi Oshima, Koki Fujikawa, Mahadi Hasan, Tatsuharu Shimokawa, Naoshi Yamazaki, Hidenori Ando, Tatsuhiro Ishida, Tatsuya Fukuta, Tamotsu Tanaka, Kentaro Kogure
International Journal of Pharmaceutics, 2020, 576, 119010 [DOI: 10.1016/j.ijpharm.2019.119010]

軸方向分散を抑えた陽イオン交換モジュールとイオンクロマトグラフィーへの応用
岡本 和将, 岡部 芹香, 田中 秀治, 竹内 政樹
FIA研究懇談会会誌, 2020, 37, 3-8 [DOI: 10.24688/jfia.37.1_3]

フラノース環酸素原子を硫黄,セレン原子に置換した核酸誘導体の有機合成化学
太田 雅士, 田良島 典子, 南川 典昭
有機合成化学協会誌, 2020, 78, 446-455 [DOI: 10.5059/yukigoseikyokaishi.78.446]

2019年

A novel intraperitoneal therapy for gastric cancer with DFP‐10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model
Hidenori Ando, Masakazu Fukushima, Kiyoshi Eshima, Taichi Hasui, Taro Shimizu, Yu Ishima, Cheng‐Long Huang, Hiromi Wada, Tatsuhiro Ishida
Cancer Medicine, 2019, 8, 7313-7321 [DOI: 10.1002/cam4.2598]

PEGylated liposomes: immunological responses
Marwa Mohamed, Amr Selim Abu Lila, Taro Shimizu, Eman Alaaeldin, Amal Hussein, Hatem A. Sarhan, Janos Szebeni, Tatsuhiro Ishida
Science and Technology of Advanced Materials, 2019, 20, 710-724 [DOI: 10.1080/14686996.2019.1627174]

Distribution of Polysulfide in Human Biological Fluids and Their Association with Amylase and Sperm Activities
Mayumi Ikeda, Yu Ishima, Victor Tuan Giam Chuang, Maki Sakai, Hiroki Osafune, Hidenori Ando, Taro Shimizu, Keiichiro Okuhira, Hiroshi Watanabe, Toru Maruyama, Masaki Otagiri, Takaaki Akaike, Tatsuhiro Ishida
Molecules, 2019, 24, 1689 [DOI: 10.3390/molecules24091689]

Cancer cell-type tropism is one of crucial determinants for the efficient systemic delivery of cancer cell-derived exosomes to tumor tissues
Sherif E. Emam, Amr Selim Abu Lila, Nehal E. Elsadek, Hidenori Ando, Taro Shimizu, Keiichiro Okuhira, Yu Ishima, Mahmoud A. Mahdy, Fakhr-eldin S. Ghazy, Tatsuhiro Ishida
European Journal of Pharmaceutics and Biopharmaceutics, 2019, 145, 27-34 [DOI: 10.1016/j.ejpb.2019.10.005]

Synthesis and biological evaluation of novel imidazole nucleosides as potential anti-dengue virus agents
Yuki Okano, Noriko Saito-Tarashima, Madoka Kurosawa, Ai Iwabu, Masashi Ota, Tadashi Watanabe, Fumihiro Kato, Takayuki Hishiki, Masahiro Fujimuro, Noriaki Minakawa
Bioorganic & Medicinal Chemistry, 2019, 27, 2181-2186 [DOI: 10.1016/j.bmc.2019.04.015]

Synthesis of nucleoside units possessing photoreactive diazirine groups on the major and minor groove faces
Tomoya Wada, Noriko Saito-Tarashima, Mayu Yamada, Yasuko Okamoto, Noriaki Minakawa
Tetrahedron Letters, 2019, 60, 1530-1533 [DOI: 10.1016/j.tetlet.2019.05.008]

Glycosylinositol phosphoceramide-specific phospholipase D activity catalyzes transphosphatidylation
Rumana Yesmin Hasi, Makoto Miyagi, Katsuya Morito, Toshiki Ishikawa, Maki Kawai-Yamada, Hiroyuki Imai, Tatsuya Fukuta, Kentaro Kogure, Kaori Kanemaru, Junji Hayashi, Ryushi Kawakami, Tamotsu Tanaka
The Journal of Biochemistry, 2019, 166, 5, 441-448 [DOI: 10.1093/jb/mvz056]

Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells
Katsuya Morito, Ryota Shimizu, Nahoko Kitamura, Si-Bum Park, Shigenobu Kishino, Jun Ogawa, Tatsuya Fukuta, Kentaro Kogure, Tamotsu Tanaka
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019, 1864, 11, 1619-1628 [DOI: 10.1016/j.bbalip.2019.07.010]

Leukocyte-mimetic liposomes possessing leukocyte membrane proteins pass through inflamed endothelial cell layer by regulating intercellular junctions
Tatsuya Fukuta, Shintaro Yoshimi, Tamotsu Tanaka, Kentaro Kogure
International Journal of Pharmaceutics, 2019, 563, 314-323 [DOI: 10.1016/j.ijpharm.2019.04.027]

Asymmetric synthesis of α-amino phosphonic acids using stable imino phosphonate as a universal precursor
Tsubasa Inokuma, Takuya Sakakibara, Takatoshi Someno, Kana Masui, Akira Shigenaga, Akira Otaka, Ken‐ichi Yamada
Chem. Eur. J., 2019, 25, 13829-13832 [DOI: 10.1002/chem.201903572]

A Photo-Activatable Peptide Mimicking Functions of Apolipoprotein A-I
Haruka Kawahara, Naoki Miyashita, Koki Tachibana, Yusuke Tsuda, Kyohei Morimoto, Kohei Tsuji, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida, Keiichiro Okuhira
Biological and Pharmaceutical Bulletin, 2019, 42, 1019-1024 [DOI: 10.1248/bpb.b19-00114]

Asymmetric Total Syntheses and Structure Elucidations of (+)-Eurotiumide F and (+)-Eurotiumide G
Atsushi Nakayama, Hideo Sato, Shuji Nagano, Sangita Karanjit, Hiroshi Imagawa, Kosuke Namba
Chemical and Pharmaceutical Bulletin, 2019, 67, 953-958 [DOI: 10.1248/cpb.c18-00948]

Efficacy of high-affinity liposomal astaxanthin on up-regulation of age-related markers induced by oxidative stress in human corneal epithelial cells
Tatsuharu Shimokawa, Mai Yoshida, Tatsuya Fukuta, Tamotsu Tanaka, Toshio Inagi, Kentaro Kogure
Journal of Clinical Biochemistry and Nutrition, 2019, 64, 1, 27-35 [DOI: 10.3164/jcbn.18-27]

2018年

A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics
Taro Shimizu, Amr S. Abu Lila, Mizuki Awata, Yukiyo Kubo, Yu Mima, Yosuke Hashimoto, Hidenori Ando, Keiichiro Okuhira, Yu Ishima, Tatsuhiro Ishida
Pharmaceutical research, 2018, 35, 223 [DOI: 10.1007/s11095-018-2505-3]

A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research
Sherif E. Emam, Hidenori Ando, Amr Selim Abu Lila, Taro Shimizu, Masami Ukawa, Keiichiro Okuhira, Yu Ishima, Mahmoud A. Mahdy, Fakhr-eldin S. Ghazy, Tatsuhiro Ishida
Biological and pharmaceutical bulletin, 2018, 41, 733-742 [DOI: 10.1248/bpb.b17-00919]

A Novel Platform for Cancer Vaccines: Antigen-Selective Delivery to Splenic Marginal Zone B Cells via Repeated Injections of PEGylated Liposomes
Taro Shimizu, Amr S. Abu Lila, Yoshino Kawaguchi, Yuna Shimazaki, Yuki Watanabe, Yu Mima, Yosuke Hashimoto, Keiichiro Okuhira, Gert Storm, Yu Ishima, Tatsuhiro Ishida
The Journal of Immunology, 2018, 201, 2969-2976 [DOI: 10.4049/jimmunol.1701351]

A hydroxyl PEG version of PEGylated liposomes and its impact on anti-PEG IgM induction and on the accelerated clearance of PEGylated liposomes
Taro Shimizu, Amr S. Abu Lila, Risako Fujita, Mizuki Awata, Munehira Kawanishi, Yosuke Hashimoto, Keiichiro Okuhira, Yu Ishima, Tatsuhiro Ishida
European journal of pharmaceutics and biopharmaceutics, 2018, 127, 142-149 [DOI: 10.1016/j.ejpb.2018.02.019]

Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways
Sherif E. Emam, Hidenori Ando, Amr S. Abu Lila, Taro Shimizu, Keiichiro Okuhira, Yu Ishima, Mahmoud A. Mahdy, Fakhr-eldin S. Ghazy, Ikuko Sagawa, Tatsuhiro Ishida
Scientific reports, 2018, 8, 14493 [DOI: 10.1038/s41598-018-32861-w]

Doxorubicin Expands in Vivo Secretion of Circulating Exosome in Mice
Sherif E. Emam, Hidenori Ando, Amr Selim Abu Lila, Shiny Kobayashi, Taro Shimizu, Keiichiro Okuhira, Yu Ishima, Tatsuhiro Ishida
Biological and pharmaceutical bulletin, 2018, 41, 1078-1083 [DOI: 10.1248/bpb.b18-00202]

Carotenoid Stereochemistry Affects Antioxidative Activity of Liposomes Co-encapsulating Astaxanthin and Tocotrienol
Misuzu Ishikawa, Shota Hirai, Tatsusada Yoshida, Natsumi Shibuya, Susumu Hama, Yu Takahashi, Tatsuya Fukuta, Tamotsu Tanaka, Shinzo Hosoi, Kentaro Kogure
Chemical and Pharmaceutical Bulletin, 2018, 66, 714-720, Highlighted Paper selected by Editor-in-Chief [DOI: 10.1248/cpb.c18-00035]

Lysophosphatidic acid in medicinal herbs protects against indomethacin-induced gastric cell damage in vivo and in vitro
Sheuli Afroz, Ayano Yagi, Kouki Fujikawa, M. Motiur Rahman, Katsuya Morito, Tatsuya Fukuta, Shiro Watanabe, Emi Kiyokage, Kazunori Toida, Taro Shimizu, Tatsuhiro Ishida, Kentaro Kogure, Akira Tokumura, Tamotsu Tanaka
Prostaglandins & Other Lipid Mediators, 2018, 135, 36-44 [DOI: 10.1016/j.prostaglandins.2018.01.003]

Unnatural base pairs for synthetic biology
Noriko Saito-Tarashima, Noriaki Minakawa
Chem. Pharm. Bull., 2018, 66, 132-138 (Selected as Front Cover)[DOI: 10.1248/cpb.c17-00685]

Four-hydrogen-bonding base pairs in oligonucleotides: design, synthesis and properties, Synthesis of Therapeutic Oligonucleotides
Noriko Saito-Tarashima, Akira Matsuda, Noriaki Minakawa
Springer, 2018, 147-169 [DOI: 10.1007/978-981-13-1912-9_9]

Cellular density‐dependent increases in HIF‐1α compete with c‐Myc to down‐regulate human EP4 receptor promoter activity through Sp-1-binding region
Naofumi Seira, Kazuyuki Yamagata, Keijo Fukushima, Yumi Araki, Naoki Kurata, Naoki Yanagisawa, Masato Mashimo, Hiroyuki Nakamura, John W. Regan, Toshihiko Murayama, Hiromichi Fujino
Pharmacology Research & Perspectives, 2018, 6, e00441 [DOI: 10.1002/prp2.441]

Direct Enantioselective Indolylation of Peptidyl Imine for the Synthesis of Indolyl Glycine-Containing Peptides
Tsubasa Inokuma, Kodai Nishida, Akira Shigenaga, Ken-ichi Yamada, Akira Otaka
Heterocycles, 2018, 97, 1269-1287 [DOI: 10.3987/COM-18-S(T)86]

Intratumoral visualization of oxaliplatin within a liposomal formulation using X-ray fluorescence spectrometry
Hidenori Ando, Amr S. Abu Lila, Masao Tanaka, Yusuke Doi, Yasuko Terada, Naoto Yagi, Taro Shimizu, Keiichiro Okuhira, Yu Ishima, Tatsuhiro Ishida
Mol. Pharm., 2018, 15, 403-409 [DOI: 10.1021/acs.molpharmaceut.7b00762]

Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens
Hidenori Ando, Amr S. Abu Lila, Munehira Kawanishi, Taro Shimizu, Keiichiro Okuhira, Yu Ishima, Tatsuhiro Ishida
J.Control. Release., 2018, 270, 114-119 [DOI: 10.1016/j.jconrel.2017.12.002]

A Novel S-Sulfhydrated Human Serum Albumin Preparation Suppresses Melanin Synthesis
Mayumi Ikeda, Yu Ishima, Ryo Kinoshita, Victor T.G. Chuang, Nanami Tasaka, Nana Matsuo, Hiroshi Watanabe, Taro Shimizu, Tatsuhiro Ishida, Masaki Otagiri, Toru Maruyama
Redox Biology, 2018, 14, 354-360 [DOI: 10.1016/j.redox.2017.10.007]

2017年

Synthesis of 4'-selenoribonucleosides, the building blocks of 4'-selenoRNA, using a hypervalent iodine
Noriko Saito‐Tarashima, Masashi Ota, Noriaki Minakawa
Curr. Protoc. Nucleic Acid Chem., 2017, 70, 1-21 [DOI: 10.1002/cpnc.34]

Synthesis and evaluation of c-di-4'-thioAMP as an artificial ligand for c-di-AMP riboswitch
Kazuto Shiraishi, Noriko Saito-Tarashima, Yosuke Igata, Keiji Murakami, Yasuko Okamoto, Yoichiro Miyake, Kazuhiro Furukawa, Noriaki Minakawa
Bioorg. Med. Chem., 2017, 25, 3883-3889 [DOI: 10.1016/j.bmc.2017.05.042]

A `catch and release' strategy towards HPLC-free purification of synthetic oligonucleotides using a phosphoramidite unit possessing a photocleavable azide linker
Yosuke Igata, Noriko Saito-Tarashima, Daiki Matsumoto, Kazuyuki Sagara, Noriaki Minakawa
Bioorg. Med. Chem., 2017, 25, 5962-5967 [DOI: 10.1016/j.bmc.2017.09.014]

Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model
Taro Shimizu, Amr S. Abu Lila, Miho Nishio, Yusuke Doi, Hidenori Ando, Masami Ukawa, Yu Ishima, Tatsuhiro Ishida
Cancer. Sci., 2017, 108, 1864-1869 [DOI: 10.1111/cas.13305]

Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules
Keiichiro Okuhira, Takuji Shoda, Risa Omura, Nobumichi Ohoka, Takayuki Hattori, Norihito Shibata, Yosuke Demizu, Ryo Sugihara, Asato Ichino, Haruka Kawahara, Yukihiro Itoh, Minoru Ishikawa, Yuichi Hashimoto, Masaaki Kurihara, Susumu Itoh, Hiroyuki Saito, Mikihiko Naito
Mol Pharmacol, 2017, 91, 159-166 [DOI: 10.1124/mol.116.105569]

Association of TUSC1 and DPF3 gene polymorphisms with male infertility
Youichi Sato, Chise Hasegawa, Atsushi Tajima, Shiari Nozawa, Miki Yoshiike, Eitetsue Koh, Jiro Kanaya, Mikio Namiki, Kiyomi Matsumiya, Akira Tsujimura, Kiyoshi Komatsu, Naoki Itoh, Jiro Eguchi, Aiko Yamauchi, Teruaki Iwamoto
J. Assist. Reprod. Genet., 2017, 35, 1-7 [DOI: 10.1007/s10815-017-1052-x]

Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model
Taro Shimizu, Amr S. Abu Lila, Miho Nishino, Yusuke Doi, Hidenori Ando, Masami Ukawa, Yu Ishima, Tatsuhiro Ishida
Cancer Sci., 2017, 108, 1864-1869 [DOI: 10.1111/cas.13305]

2016年

A replication study of a candidate locus for follicle-stimulating hormone levels and association analysis for semen quality traitsin Japanese men
Youichi Sato, Atsushi Tajima, Motoki Katsurayama, Shiari Nozawa, Miki Yoshiike, Eitetsue Koh, Jiro Kanaya, Mikio Namiki, Kiyomi Matsumiya, Akira Tsujimura, Kiyoshi Komatsu, Naoki Itoh, Jiro Eguchi, Issei Imoto, Aiko Yamauchi, Teruaki Iwamoto
Journal of Human Genetics, 2016, 61, 911–915 [DOI: 10.1038/jhg.2016.82]

2015年冬季の徳島市における水溶性酸性ガス及びPM2.5に含まれる陰イオンのオンライン分析
富安 直弥, 並川 誠, 田中 秀治, 竹内 政樹
BUNSEKI KAGAKU, 2016, 65, 8, 425-432 [DOI: 10.2116/bunsekikagaku.65.425]

Gene silencing using 4'-thioDNA as an artificial template to synthesize short-hairpin RNA without inducing a detectable innate immune response
Noriko Tarashima, Hidenori Ando, Takamitsu Kojima, Nozomi Kinjyo, Yosuke Hashimoto, Kazuhiro Furukawa, Tatsuhiro Ishida, Noriaki Minakawa
Mol. Ther. - Nucl. Acids., 2016, 5, e274 [DOI: 10.1038/mtna.2015.48]

Encapsulation in a rapid-release liposomal formulation enhances the anti-tumor efficacy of pemetrexed in a murine solid mesothelioma-xenograft model
Noha Essam Eldin, Amr S Abu Lila, Kazuyoshi Kawazoe, Hanan M Elnahas, Mahmoud A Mahdy, Tatsuhiro Ishida
Eur. J. Pharm., 2016, 81, 60-66 [DOI: 10.1016/j.ejps.2015.09.015]

Analysis of Molecular Species Profiles of Ceramide-1-phosphate and Sphingomyelin Using MALDI-TOF Mass Spectrometry
Ryouhei Yamashita, Yumika Tabata, Erina Iga, Michiyasu Nakao, Shigeki Sano, Kentaro Kogure, Akira Tokumura, Tamotsu Tanaka
Lipids, 2016, 51, 263-270 [DOI: 10.1007/s11745-015-4082-0]

2015年

Cellular Interaction and Cytotoxicity of the Iowa Mutation of Apolipoprotein A-I(ApoA-IIowa) Amyloid Mediated by Sulfate Moieties of Heparan Sulfate
Kaori Kuwabara, Kazuchika Nishitsuji, Kenji Uchimura, Shang-Cheng Hung, Makoto Mizuguchi, Hiroyuki Nakajima, Shiho Mikawa, Norihiro Kobayashi, Hiroyuki Saito, Naomi Sakashita
J. Biol. Chem., 2015, 290, 24210-24221 [DOI: 10.1074/jbc.M115.652545]

Advanced therapeutic approach for the treatment of malignant pleural mesothelioma via the intrapleural administration of liposomal pemetrexed
Hidenori Ando, Sakiko Kobayashi, Amr S Abu Lila, Noha Essam Eldin, Chihiro Kato, Taro Shimizu, Masami Ukawa, Kazuyoshi Kawazoe, Tatsuhiro Ishida
J. Control. Release., 2015, 29-36 [DOI: 10.1016/j.jconrel.2015.10.019]

Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes
Chiharu Mizuguchi, Fuka Ogata, Shiho Mikawa, Kohei Tsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Keiichiro Okuhira, Akira Otaka, Hiroyuki Saito
J. Biol. Chem., 2015, 290, 20947-20959 [DOI: 10.1074/jbc.M115.664227]

Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells
Taro Shimizu, Yu Mima, Yosuke Hashimoto, Masami Ukawa, Hidenori Ando, Hiroshi Kiwada, Tatsuhiro Ishida
Immunobiology, 2015, 220, 1151-1160 [DOI: 10.1016/j.imbio.2015.06.005]

Anti-PEG IgM Is a Major Contributor to the Accelerated Blood Clearance of Polyethylene Glycol-Conjugated Protein
Yu Mima, Yosuke Hashimoto, Taro Shimizu, Hiroshi Kiwada, Tatsuhiro Ishida
Mol. Pharmaceutics., 2015, 12, 2429-2435 [DOI: 10.1021/acs.molpharmaceut.5b00144]

Faithful PCR Amplification of an Unnatural Base-Pair Analogue with Four Hydrogen Bond
Noriko Tarashima, Yasuo Komatsu, Kazuhiro Furukawa, Noriaki Minakawa
Chem. Eur. J., 2015, 21, 10688-10695 [DOI: 10.1002/chem.201583062]

Synthesis of DNA fragments containing 2'-deoxy-4'-selenonucleoside units using DNA polymerases: comparison of dNTPs with O, S and Se at the 4'-position in replication
Noriko Tarashima, Tatsuya Sumitomo, Hidenori Ando, Kazuhiro Furukawa, Tatsuhiro Ishida, Noriaki Minakawa
Org. Biomol. Chem., 2015, 13, 6949-6952 [DOI: 10.1039/c5ob00941c]

Molecular Complex Composed of β‑Cyclodextrin-Grafted Chitosan and pH-Sensitive Amphipathic Peptide for Enhancing Cellular Cholesterol Efflux under Acidic pH
Yuki Takechi-Haraya, Kento Tanaka, Kohei Tsuji, Yasuo Asami, Hironori Izawa, Akira Shigenaga, Akira Otaka, Hiroyuki Saito, and Kohsaku Kawakami
Bioconjugate Chem, 2015, 26, 572-581 [DOI: 10.1021/acs.bioconjchem.5b00037]

Kinetic and Thermodynamic Analyses of Spontaneous Exchange between High-Density Lipoprotein-Bound and Lipid-Free Apolipoprotein A‑I
Daisuke Handa, Hitoshi Kimura, Tatsuya Oka, Yuki Takechi, Keiichiro Okuhira, Michael C. Phillips, Hiroyuki Saito
Biochemistry, 2015, 54, 1123-1131 [DOI: 10.1021/bi501345j]

Liposomal Pemetrexed: Formulation, Characterization and in Vitro Cytotoxicity Studies for Effective Management of Malignant Pleural Mesothelioma
Noha Essam Eldin, Hanan Mohamed Elnahas, Mahmoud Abd-Elghany Mahdy, Tatsuhiro Ishida
Biol. Pharm. Bull., 2015, 38, 461-469 [DOI: 10.1248/bpb.b14-00769]

Nafion Membrane Tube-Based On-Line Concentrator. Application to Urinary Orotic Acid Determined by Suppressed Ion Chromatography
Masaki Takeuchi, Naoyuki Miki, Kiichi Ishimine, Hideji Tanaka
J. Flow Injection Anal., 2015, 32, 2, 97-100, JFIA(Journal of Flow Injection Analysis) Selection Award [DOI: 10.24688/jfia.32.2_97]

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