神経病態解析学分野 研究業績 (2020)

1. Ogawa M, Zhou Y, Tsuji R, Goto S, Kasahara J.
Video-based assessments of the hind limb stepping in a mouse model of hemi-parkinsonism.
Neuroscience Research 154:56-59

神経病態解析学分野 研究業績 (2019)

1. Ogawa M, Zhou Y, Tsuji R, Kasahara J, Goto S.
Intrastriatal memantine infusion dampens levodopa-induced dyskinesia and motor deficits in a mouse model of hemi-parkinsonism.
Frontiers in Neurology 10:1258 Epub

2. 笠原 二郎
阿波力士 三ッノ海茂八の軌跡をたどる
相撲趣味 186:1-6 （#地域社会貢献）

3. Miyake K, Sakane A, Tsuchiya Y, Sagawa I, Tomida Y, Kasahara J, Imoto I, Watanabe S, Higo D, Mizuguchi K, Sasaki T.
Actin cytoskeletal reorganization function of JRAB/MICAL-L2 is fine-tuned by intramolecular interaction between first LIM zinc finger and C-terminal coiled-coil domains.
Scientific Reports 10:12794 Epub

神経病態解析学分野 研究業績 (2018)

1. Zhou Y, Yamamura Y, Ogawa M, Tsuji R, Tsuchiya K, Kasahara J, Goto S.
c-Abl Inhibition Exerts Symptomatic Antiparkinsonian Effects Through a Striatal Postsynaptic Mechanism.
Frontiers in Pharmacology 9:1311 Epub

神経病態解析学分野 研究業績 (2017)

1. Kasahara J, Choudhury ME, Nishikawa N, Tanabe A, Tsuji R, Zhou Y, Ogawa M, Yokoyama H, Tanaka J, Nomoto M.
Neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal models of Parkinson's disease.
Animal Models for The Study of Human Disease (Ch 41), 2nd Ed (Edited by Conn PM): Academic Press:1087-1108

神経病態解析学分野 研究業績 (2016)

1. Kasahara J, Uchida H, Tezuka K, Oka N.
Postischemic anhedonia associated with neurodegenerative changes in the hippocampal dentate gyrus of rats Neural Plasticity 2016:5054275 Epub

神経病態解析学分野 研究業績 (2015)

1. Kikuta S, Nakamura Y, Yamamura Y, Tamura A, Homma N, Yanagawa Y, Tamura H, Kasahara J, Osanai M.
Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice Scientific Reports 5:12800 Epub

神経病態解析学分野 研究業績 (2014)

1. Kadoguchi N, Okabe S, Yamamura Y, Shono M, Fukano T, Tanabe A, Yokoyama H, Kasahara J.
Mirtazapine has a therapeutic potency in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model of Parkinson's disease BMC Neuroscience 15:79 Epub

2. Tanabe A, Yamamura Y, Kasahara J, Morigaki R, Kaji R, Goto S.
A novel tyrosine kinase inhibitor AMN107 (nilotinib) normalizes striatal motor behaviors in a mouse model of Parkinson's disease Frontiers in Cellular Neuroscience 8:50 Epub

神経病態解析学分野 研究業績 (2013)

1. Kasahara J, Choudhury ME, Yokoyama H, Kadoguchi N, Nomoto M. Neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced animal models for Parkinson's disease.
Animal Models for The Study of Human Disease (Edited by Conn PM): Academic Press:633-650

2. Yamamura Y, Morigaki R, Kasahara J, Yokoyama H, Tanabe A, Okita S, Koizumi H, Nagahiro S, Kaji R, Goto S.
Dopamine signaling negatively regulates striatal phosphorylation of Cdk5 at tyrosine 15 in mice Frontiers in Cellular Neuroscience 7:12 Epub

神経病態解析学分野 研究業績 (2011)

1. Morigaki R, Sako W, Okita S, Kasahara J, Yokoyama H, Nagahiro S, Kaji R, Goto S.
Cyclin-dependent kinase 5 with phosphorylation of tyrosine 15 residue is enriched in striatal matrix compartment in adult mice.
Neuroscience 189:25-31

2. Yokoyama H, Uchida H, Kuroiwa H, Kasahara J, Araki T.
Role of glial cells in neurotoxin-induced animal models of Parkinson's disease.
Neurological Science 32(1):1-7

3. Yokoyama H, Kuroiwa H, Kasahara J, Araki T.
Neuropharmacological approach against MPTP-induced mouse model of Parkinson's disease.
Acta Neurobiologiae Experimentalis (Wars) 71(2):269-280

神経病態解析学分野(旧病態神経薬学分野)研究業績 (2010)

1. Adachi M, Abe M, Sasaki T, Kato H, Kasahara J, Araki T.
Role of inducible or neuronal nitric oxide synthase in neurogenesis of the dentate gyrus in aged mice.
Metabolic Brain Disease 25(4):419-424

2. Uchida H, Fujita Y, Matsueda M, Umeda M, Matsuda S, Kato H, Kasahara J, Araki T.
Damage to neurons and oligodendrocytes in the hippocampal CA1 sector after transient focal ischemia in rats.
Cellular and Molecular Neurobiology 30(7):1125-1134

3. Kuroiwa H, Yokoyama H, Kimoto H, Kato H, Araki T.
Biochemical alterations of the striatum in an MPTP-treated mouse model of Parkinson's disease.
Metabolic Brain Disease 25(2):177-183

4. Yokoyama H, Yano R, Kuroiwa H, Tsukada T, Uchida H, Kato H, Kasahara J, Araki T.
Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)neurotoxicity in mice.
Metabolic Brain Disease 25(2):135-143

5. Abe M, Kimoto H, Eto R, Sasaki T, Kato H, Kasahara J, Araki T.
Postnatal development of neurons, interneurons and glial cells in the substantia nigra of mice.
Cellular and Molecular Neurobiolgy 30(6):917-928

6. Eto R, Abe M, Kimoto H, Imaoka E, Kato H, Kasahara J, Araki T.
Alterations of interneurons in the striatum and frontal cortex of mice during postnatal development.
International Journal of Developmental Neuroscience 28(5):359-370

7. Uchida H, Yokoyama H, Kimoto H, Kato H, Araki T.
Long-term changes in the ipsilateral substantia nigra after transient focal cerebral ischaemia in rats.
International Journal of Experimental Pathology 91(3):256-266

8. Yokoyama H, Kuroiwa H, Tsukada T, Uchida H, Kato H, Araki T
Poly(ADP-ribose)polymerase (PARP) inhibitor can attenuate the neuronal death after MPTP-induced neurotoxicity in mice.
Journal of Neuroscience Research 88:1522-1536.

9. Aoki E, Yokoyama H, Kimoto H, Yano R, Kato H, Araki T
Chronic administration with rotenone does not enhance MPTP neurotoxicity in C57BL/6 mice.
Journal of Molecular Neuroscience 41:17-14.

10. Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T
Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.
PLoS One 5:e9460.

11. 黒岩勇人, 横山宏典, 内田裕人, 塚田竜矢, 加藤宏之, 笠原二郎, 荒木 勉
MPTP誘発パーキンソン病モデルマウスに対するPARP阻害剤およびPPAR作動薬の神経細胞保護効果に関する研究ーzonisamideとの比較研究ー
脳21 13 (No.3);116

病態神経薬学分野 研究業績 (2009)

1. Aoki E, Yano R, Yokoyama H, Kato H, Araki T
Role of nuclear transcription factor Kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced apoptosis in nigral neurons of mice.
Experimental and Molecular Pathology 86:57-64.

2. Matsuda S, Umeda M, Kato H, Araki T
Glial damage after transient focal cerebral ischemia in rats.
Journal of Molecular Neuroscience 38:220-226.

3. Yano R, Yokoyama H, Kuroiwa H, Kato H, Araki T
A novel anti-parkinsonian agent, zonisamide, attenuates MPTP-induced neurotoxicity in mice.
Journal of Molecular Neuroscience 39:211-219.

4. Matsuda S, Umeda M,Uchida H, Kato H, Araki T
Alterations of oxidative stress markers and apoptosis markers in the striatum after transient focal cerebral ischemia in rats.
Journal of Neural Transmission 116:395-404.

5. Oshikawa T, Kuroiwa H, Yano R, Yokoyama H, Kadoguchi N, Kato H, Araki T
Systematic administration of proteasome inhibitor protects against MPTP neurotoxicity in mice.
Cellular and Molecular Neurobiology 29:769-777.

6. Kimoto H, Eto R, Abe M, Kato H, Araki T
Alterations of glial cells in the mouse hippocampus during postnatal development.
Cellular and Molecular Neurobiology 29:1181-1189.

7. Yano R, Yokoyama H, Kuroiwa H, Kato H, Araki T
A novel anti-parkinsonian agent, zonisamide, attenuates MPTP-induced neurotoxicity in mice.
Journal of Molecular Neuroscience 39:320.

8. Ookubo M, Yokoyama H, Kato H, Araki T
Gendder differences on MPTP (1-methyl-4-phenyl-1,2,3,6-tetraphydropyridine) neurotoxicity in mice.
Molecular and Cellular Endocrinology 311:62-68.

9. 横山宏典, 矢野遼平, 塚田竜矢, 佐々木妙子, 加藤宏之, 荒木 勉
MPTP誘発パーキンソン病モデルマウスに対するゾニサミドの神経細胞保護効果に関する基礎的検討
脳21 12:114.

10. Yokoyama H, Tsukada T, Uchida H, Araki T.
Novel therapies in an MPTP model of Parkinson's disease.
Current Trends in Neurology 3:23-31(Review).

11. Takemura M, Mishima T, Wang Y. Kasahara J, Fukunaga K, Ohashi K, Mizuno K.
Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.
Journal of Biological Chemistry 284(42):28554-28562

病態神経薬学分野 学生中心の研究業績 (2008)

1. Watanabe Y, Kato H, Araki T
Protective action of neuronal nitric oxide synthase inhibitor in the MPTP mouse model of Parkinson's disease.
Metabolic Brain Disease 23:51-69.

2. Oki C, Watanabe Y, Yokoyama H, Shimoda T, Kato H, Araki T
Delayed treatment with Arundic acid reduces the MPTP-induced neurotoxicity in mice.
Cellular and Molecular Neurobiology 28:417-430.

3. Sakuma M, Hayakawa N, Kato H, Araki T
Time dependent changes of striatal interneurons after focal cerebral ischemia in rats.
Journal of Neural Transmission 115:413-422.

4. Kadoguchi N, Kimoto H, Yano R, Kato H, Araki T
Failure of acute administration with proteasome inhibitor to provide a model of Parkinson's disease in mice.
Metabolic Brain Disease 23:147-154.

5. 佐久間美央, 早川夏美, 梅田真洋, 松田俊輔, 荒木 勉
一過性脳梗塞ラットモデルの梗塞中心部におけるインターニューロンの経時的変動
Phrama Medica 26:125.

6. Yokoyama H, Takagi S, Watanabe Y, Kato H, Araki T
Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice.
Journal of Neural Transmission 115:831-842.

7. Kadoguchi N, Umeda M, Kato H, Araki T
Proteasome inhibitor does not enhance MPTP neurotoxicity in mice.
Cellular and Molecular Neurobiology 28:971-979.

8. Hayakawa N, Abe M, Eto R, Kato H, Araki T
Age-related changes of NGF, BDNF, parvalbumin and neuronal nitric oxide synthase immunoreactivity in the mouse hippocampal CA1 sector.
Metabolic Brain Disease 23:199-211.

9. Hayakawa N, Yokoyama H, Kato H, Araki T
Age-related alterations of oxidative stress markers in the mouse hippocampal CA1 sector.
Experimental and Molecular Pathology 85:135-140.

10. Yokoyama H, Yano R, Aoki E, Kato H, Araki T
Comparative study of inhibitors of free radical, nitric oxide synthase and inflammation against MPTP neurotoxicity in mice. Metabolic Brain Disease 23:335-349.

11. 横山宏典、矢野遼平、高木翔、黒岩勇人、加藤宏之、荒木勉
MPTP誘発パーキンソン病モデルマウスに対する各種薬剤の神経細胞保護効果に関する検討
脳21 11:381.

12. 門口直仁、高木翔、荒木勉
創薬支援研究の展望:第8章 実験的パーキンソン病モデル動物を用いた新規薬物療法の開発研究
pp78-85, シーエムーシー社

13. Eto R, Abe M, Hayakawa N, Kato H, Araki T
Age-related changes of calcineurin and Akt1/protein kainase (Akt1/PKB) immunereactivity in the mouse hippocampal CA1
sector: an immunohistochemical study.
Metabolic Brain Disease 23:399-409.

14. Ookubo M, Yokoyama H, Takagi S, Kato H, Araki T
Effects of estrogens on striatal damage after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in male and female mice.
Molecular and Cellular Endocrinology 296:87-93.

15. Yokoyama H, Kuroiwa H, Yano R, Araki T
Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson's disease.
Neurological Sciences 29:293-301. (Review)

病態神経薬学分野 学生中心の研究業績 (2007)

1. Tounai H, Haykawa N, Kato H, Araki T
Immunohistochemical study on distribution on NF-kB and p53 in gerbil hippocampus after transient cerebral ischemia: effect of pitavastatin.
Metabolic Brain Disease 22:89-104.

2. Tanaka A, Watanabe Y, Kato H, Araki T
Immunohistochemical changes related to ageing in the mouse hippocampus and subventricular zone.
Mechanisms of Ageing and Development 128:303-310.

3. Hayakawa N, Kato H, Araki T
Age-related changes of astrocytes, oligodendrocytes and microglia in the mouse hippocampal CA1 sector.
Mechanisms of Ageing and Development 128:311-316.

4. Takagi S, Hayakawa N, Kimoto H, Kato H, Araki T
Damage of oligodendrocytes in the striatum after MPTP neurotoxicity in mice.
Journal of Neural Transmission 114:1553-1557.