研究業績

2017年度

  1. Nishida, K., Shiba, S., Muroki, K., Ohishi, A., Doi, Y., Ando, H., Ishida, T., Nagasawa, K., Liposomalization of oxaliplatin induces skin accumulation of it, but negligible skin toxicity. Toxicol. Appl. Pharmacol., in press (2017)
  2. Ikeda, M., Ishima, Y., Kinoshita, R., Chuang, V., Tasaka, N., Matsuo, N., Watanabe, H., Shimizu, T., Ishida, T., Otagiri, M., Maruyama, T., A Novel S-Sulfhydrated Human Serum Albumin Preparation Suppresses Melanin Synthesis, Redox Biology, in press (2017)
  3. 清水太郎、異島 優、石田竜弘、ナノ粒子に対する補体活性化の功罪、Drug Deliv. Sys., 32, 199-207 (2017)
  4. Abu Lila, A.S., Janos. S., Ishida, T., Accelerated blood clearance phenomenon and complement activation-related pseudoallergy: two sides of the same coin. Pan Stanford Publishing, a book chapter, in press (2017)
  5. Kinoshita, R., Ishima, Y., Chuang, V., Nakamura, H., Fang, J., Watanabe, H., Shimizu, T., Okuhira, K., Ishida, T., Maeda, H., Otagiri, M., Maruyama, T., Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-Nitrosated Human Serum Albumin Dimer. Biomaterials, 140, 162-169 (2017)
  6. Shimizu, T., Abu Lila, A.S., Nishio, M., Doi, Y., Ando, H., Ukawa, M., Ishima, Y., Ishida, T., Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model. Cancer Sci., 108, 1864-1869 (2017)
  7. Alaaeldin, E., Abu Lila, A.S., Ando, H., Fukushima, M., Huang, C., Wada, H., Sarhan, H.A., Khaled, K.A., Ishidaa, T., Co-administration of liposomal l-OHP and PEGylated TS shRNA-lipoplex: A novel approach to enhance anti-tumor efficacy and reduce the immunogenic response to RNAi molecules. J. Control. Release, 255, 210-217 (2017)
  8. Ikeda, M., Ishima, Y, Chuang, V., Ikeda, T., Kinoshita, R., Watanabe, H., Ishida, T., Otagiri, M., Maruyama, T., Apoptosis induction of Poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition. Nitric Oxide, 69, 28-34 (2017)
  9. Ikeda, M., Ishima, Y., Shibata, A., Chuang, V., Sawa, T., Ihara, H., Watanabe, H., Xian, M., Ouchi, Y., Shimizu, T., Ando, H., Ukawa, M., Ishida, T., Akaike, T., Otagiri, M., Maruyama, T., Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach. Anal. Chim. Acta, 969, 18-25 (2017)
  10. Mima, Y., Abu Lila, A.S., Shimizu, T., Ukawa, M., Ando, H., Kurata, Y., Ishida, T., Ganglioside inserted into PEGylated liposome attenuates anti-PEG immunity. J. Control Release, 250, 20-26 (2017)
  11. Matsuda, T., Hiraoka, S., Urashim, H., Ogura, A., Ishida, T., Preparation of an ultrafine rebamipide ophthalmic suspension with high transparency. Biol. Pharm. Bull., 40, 665-674 (2017)
  12. Abu Lila, A.S., Moriyoshi, N., Fukushima, M., Huang, C., Wada, H., Ishida, T., Metronomic S-1 dosing and thymidylate synthase silencing have synergistic antitumor efficacy in a colorectal cancer xenograft model. Cancer Letters , 400, 223-231 (2017)
  13. Abu Lila, A.S., Ishida, T., Metronomic chemotherapy and nanocarrier platforms. Cancer Letters., 400, 232-242 (2017)
  14. Abu Lila, A.S., Kiwada, H., Ishida, T., Liposomal delivery systems: design optimization and current applications. Biol. Pharm. Bull., 40, 1-10 (2017)
  15. Abu Lila, A.S., Shimizu, T., Ishida, T., PEGylation and anti-PEG antibodies. Pan Stanford Publishing, a book chapter, in press (2017)
  16. Abu Lila, A.S., Ishida, T., The accelerated blood clearance (ABC) phenomenon of PEGylated nanocarriers. Pan Stanford Publishing, a book chapter, in press (2017)
  17. Abu Lila, A.S., Ishida, T., Anti-PEG immunity against PEGylated therapeutics.Elsevier, a book chapter, in press (2017)

  

研究費獲得状況

  1. 研究助成金「山田養蜂場」(新規)
  2. 研究助成金「武田科学振興財団」(新規)
  3. 小規模研究会助成金「テルモ生命科学芸術財団」(新規)
  4. 平成28年度戦略的基盤技術高度化支援事業(継続)
  5. 研究助成金「高橋産業経済研究財団」(継続)
  6. 科学研究費補助金「若手B」(新規)
  7. 科学研究費補助金「挑戦的萌芽研究」(継続)
  8. 科学研究費補助金「基盤C」(継続)
  9. 科学研究費補助金「国際共同研究加速基金」(継続)
  10. 研究助成金「大阪コミュニティ財団」(新規)
  11. 科学研究費補助金「基盤B」(継続)
  12. 橋渡し研究・新規開発シーズ(シーズA 九州大学拠点)(新規)
  13. 橋渡し研究・新規開発シーズ(シーズA 九州大学拠点)(新規)

   

2016年度

  1. Doi, Y., Abu Lila, A.S., Matsumoto, H., Okada, T., Shimizu, T., Ishida, T., Improvement of intratumor microdistribution of PEGylated liposome via tumor priming by metronomic S-1 dosing. Int. J. Nanomed., 11, 5573-5582 (2016)
  2. Abu Lila, A.S., Fukushima, M., Huang, C., Wada, H., Ishida, T., Systemically administered RNAi molecule sensitizes malignant pleural mesothelioma cells to pemetrexed therapy. Mol. Pharmaceut., 13, 3955-3963 (2016)
  3. 清水太郎、石田竜弘、Poly(ethylene glycol)に対する抗体の特性、評価、抑制、Drug Deliv. Sys., 31, 300-307 (2016)
  4. Shibata, A., Ishima, Y., Ikeda, M., Sato, H., Imafuku, T., Chuang, V., Ouchi, Y., Abe, T., Watanabe, H., Ishida, T., Otagiri, M., Maruyama, T., Human Serum Albumin Hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as Chronic Kidney Disease. Biochim. Biophys. Res. Commun. 479, 578-583 (2016)
  5. Takayama, T., Ukawa, M., Kanazawa, Y., Ando, H., Shimizu, T., Ishida, T., Hydrodynamic tail vein injection as a simple tool for yielding extended transgene expression in solid tumors. Biol. Pharm. Bull., 39, 1-4 (2016)
  6. Miwa, Y., Hamamoto H., Ishida, T., Lidocaine self-sacrificially improves the skin permeation of the acidic and poorly water-soluble drug etodolac via its transformation into an ionic liquid. Eur. J. Pharm. Biopharm., 102, 92-100 (2016)
  7. Abu Lila, A.S., Kato, C., Fukushima, M., Huang, C., Wada, H., Ishida, T., Downregulation of thymidylate synthase by RNAi molecules enhances the antitumor effect of pemetrexed in an orthotopic malignant mesothelioma xenograft mouse model. Int. J. Oncol., 48, 1399-1407 (2016)
  8. Ukawa, M., Fujiwara, Y., Ando, H., Shimizu, T., Ishida, T., Hepatic tumor metastases cause enhanced PEGylated liposome uptake by Kupffer cells. Biol. Pharm. Bull., 39, 215-220 (2016)
  9. 石田竜弘、PEGに対する免疫反応~PEG修飾製剤の安全性に関する研究~、製剤機械技術学会誌、24, 78-83 (2016)
  10. Tarashima, N., Ando, H., Kojima, T., Kinjyo, N., Hashimoto, Y., Furukawa, K., Ishida, T., Minakawa, N., Gene silencing using 4'-thioDNA as an artificial template to synthesize short-hairpin RNA without inducing a detectable innate immune response. Mol. Ther. - Nucleic Acids, 5, e274 (2016)
  11. Essam Eldin, N., Abu Lila, A.S., Kawazoe, K., Elnahas, H.M., Mahdy, M.A., Ishida, T., Encapsulation in a rapid-release liposomal formulation enhances the anti-tumor efficacy of pemetrexed in a murine solid mesothelioma-xenograft model. Eur. J. Pharm. Sci., 81, 60-66 (2016)

  

研究費獲得状況

  1. 平成28年度戦略的基盤技術高度化支援事業(新規)
  2. 研究助成金「永井記念薬学国際交流財団」(新規)
  3. 研究助成金「高橋産業経済研究財団」(新規)
  4. 科学研究費補助金「若手B」(新規)
  5. 科学研究費補助金「挑戦的萌芽研究」(新規)
  6. 科学研究費補助金「基盤C」(継続)
  7. 日本科学協会「笹川科学研究助成金」(新規)
  8. 科学研究費補助金「国際共同研究加速基金」(新規)
  9. 上原記念生命科学財団「研究推進特別奨励金」(新規)
  10. 科学研究費補助金「基盤B」(継続)
  11. 科学研究費補助金「若手研究B」(継続)
  12. 科学研究費補助金「若手研究B」(継続)

   

2015年度

  1. Nakamura, H., Abu Lila A.S., Nishio, M., Tanaka, M., Ando, H., Kiwada, H., Ishida, T., Intra-tumor distribution of PEGylated liposome upon repeated injection: No possession by prior dose. J. Control. Release, 220, 406-413 (2015)
  2. Ando, H., Kobayashi, S., Abu Lila A.S., Essam Eldin N., Kato, C., Shimizu, T., Ukawa, M., Kawazoe, K., Ishida, T., Advanced therapeutic approach for the treatment of malignant pleural mesothelioma via the intrapleural administration of liposomal pemetrexed. J. Control. Release, 220, 29-36 (2015)
  3. 石田竜弘、安藤英紀、実践 製剤学 ~そしてその基盤となる物理薬剤学~(飯村菜穂子、萩原琢男編) 第11章 ドラッグデリバリーシステム(DDS)、447-471 (2015)
  4. Ukawa, M., Ando, H., Shimizu, T., Ishida, T., Pharmaceutics of Nanoparticles, A book chapter in Nanomaterials in Pharmacology, Chapter 11, in press, Lu, Z.R. and Sakuma, S. (Ed.), Springer Science+Business Media, New York, USA, 219-238 (2015)
  5. Mima, Y., Hashimoto, Y., Shimizu, T., Kiwada, H., Ishida, T., Anti-PEG IgM is a major contributor to the accelerated blood clearance of polyethylene glycol-conjugated protein. Mol. Pharmaceutics, 12, 2429-2435 (2015)
  6. Shimizu, T., Mima, Y., Hashimoto, Y., Ukawa, M., Ando, H., Kiwada, H., Ishida, T., Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells. Immunobiol. 220, 1151-1160 (2015)
  7. Tarashima, N., Sumitomo, T., Ando, H., Furukawa, K., Ishida, T., Minakawa, N., Synthesis of DNA fragments containing 2’-deoxy-4’-selenonucleoside units using DNA polymerases: comparison of dNTPs with O, S and Se at the 4’-position in replication Org. Biomol. Chem., 13, 6949-6952 (2015)
  8. Essam Eldin, N., Elnahas, H.M., Mahdy M.A., Ishida, T., Liposomal pemetrexed: Formulation, characterization and in vitro cytotoxicity studies for effective management of malignant pleural mesothelioma. Biol. Pharm.Bull., 38, 461-469 (2015)
  9. Hashimoto, Y., Shimizu, T., Abu Lila, A., Ishida, T., Kiwada, H., Relationship between the concentration of anti-polyethylene glycol (PEG) in immunoglobulin M (IgM) and the intensity of the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes in mice. Biol. Pharm.Bull., 38, 417-424 (2015)
  10. Kawanishi, M., Hashimoto, Y., Shimizu, T., Sagawa, I., Ishida, T., Kiwada, H., Comprehensive analysis of PEGylated liposome-asscociated proteins relating to the accelerated blood clearance phenomenon by combination with shotgun analysis and conventional methods. Biotech. Appl. Biochem. 62, 547-555 (2015)

  

研究費獲得状況

  1. 研究助成金「コスメトロジー研究振興財団」(新規)
  2. 武田科学振興財団「薬学系研究奨励継続助成」(新規)
  3. 武田科学振興財団「薬学系研究奨励」(新規)
  4. 科学研究費補助金「基盤B」(新規)
  5. 科学研究費補助金「若手研究B」(新規)
  6. 科学研究費補助金「若手研究B」(新規)
  7. 永井記念薬学国際交流財団「Research Grant」(新規)
  8. 研究助成金「大阪コミュニティ財団」(新規)
  9. 日本科学協会「笹川科学研究助成金」(新規)
  10. 科学研究費補助金「挑戦的萌芽研究」(継続)
  11. 科学研究費補助金「研究活動スタート支援」(継続)

   

2014年度

  1. Suzuki, T., Ichihara, M., Hyodo, K., Yamamoto, E., Ishida, T., Kiwada, H., Kikuchi, H., Ishihara, H., Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin. Int. J. Pharm. 476, 205-212 (2014)
  2. Saito, Y., Hashimoto, Y., Arai, M., Tarashima, N., Miyazawa, T., Miki, K., Takahashi, M., Furukawa, K., Yamazaki, N., Matsuda, A., Ishida, T., Minakawa, N., Chemistry, properties, and in vitro and in vivo applications of 2’-O-methoxyethyl-4’-thioRNA, a novel hybrid type of chemically-modified RNA. ChemBioChem, 15, 2535-2540 (2014)
  3. Abu Lila, A.S., Ishida, T., Allen, T.M., Liposomal nanomedicine, in Frontiers of Nanobiomedical Research, Torchilin, V. (Ed.), World Scientific, 1, 1-53 (2014)
  4. Hashimoto, Y., Abu Lila A., Shimizu, T., Ishida, T., Kiwada, H. B cell-intrinsic toll-like receptor 7 is responsible for the enhanced anti-PEG IgM production following injection of siRNA-containing PEGylated lipoplex in mice. J. Control. Release, 184, 1-8 (2014)
  5. Hashimoto, Y., Shimizu, T., Mima, Y., Abu Lila A., Ishida, T., Kiwada, H., Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs. Toxicol. Appl. Pharmacol., 277, 30-38 (2014)
  6. Abu Lila, A.S., Kiwada, H., Ishida, T., Selective delivery of oxaliplatin to tumor tissue by nanocarrier system enhances the overall therapeutic efficacy of the encapsulated oxaliplatin. Biol. Pharm. Bull., 206-211 (2014)
  7. Hashimoto, Y., Uehara, Y., Abu Lila A., Ishida, T., Kiwada, H., Activation of TLR9 by incorporated pDNA within PEG-coated lipoplex enhances anti-PEG IgM production. Gene Ther. 21, 593-598 (2014)
  8. Nakashima, T., Sako, N., Matsuda, T., Uematsu, N., Sakurai, K., Ishida, T., Novel Submicronized Rebamipide Liquid with Moderate Viscosity: Significant Effects on Oral Mucositis in Animal Models. Biol. Pharm. Bull, 37, 671-678 (2014)
  9. Mori, H., Kawai, N., Kinouchi, N., Hichijo, N., Ishida, T., Kawakami, E., Noji, S., Tanaka, E., Effectiveness of cationic liposome-mediated local delivery of myostatin-targeting small interfering RNA in vivo. Develop. Growth Differ. 56, 223-232 (2014)
  10. Nakamura, H., Doi, Y., Abu Lila, A.S., Nagao, A., Ishida, T., Kiwada, H., Sequential treatment of oxaliplatin-containing PEGylated liposome together with S-1 improves intratumor distribution of subsequent doses of oxaliplatin-containing PEGylated liposome. Eur. J. Pharm. Biopharm., 87, 142-151 (2014)
  11. Abu Lila, A.S., Uehara, Y., Ishida, T., Kiwada, H., Application of polyglycerol-coating to pDNA lipoplex for the evasion of the accelerated blood clearance (ABC) phenomenon in nucleic acid delivery. J. Pharm. Sci., 103, 557-566 (2014)

  

研究費獲得状況

  1. 四国5大学男女共同参画推進連絡協議会「女性研究者活動支援」(新規)
  2. 科学研究費補助金「研究活動スタート支援」(新規)
  3. テルモ科学技術振興財団「国際交流助成金」(新規)
  4. 科学研究費補助金「挑戦的萌芽研究」(新規)
  5. 科学研究費補助金「特別研究員奨励費」(継続)
  6. 科学研究費補助金「基盤B」(継続)

   

2013年度

  1. Nakashima, T., Uematsu, N., Shibamori, M., Sakurai, K., Ishida, T., Kiwada, H., Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. J. Pharmacol. Exp. Ther., 347, 660-668 (2013)
  2. Abu Lila, A.S., Ichihara, M., Shimizu, T., Ishida, T., Kiwada, H., Ex-Vivo/In-Vitro Anti-Polyethylene Glycol (PEG) IgM Production From Murine Splenic B Cells Stimulated by PEGylated Liposome. Biol. Pharm. Bull, 36, 1842-1848 (2013)
  3. Abu Lila, A.S., Kiwada, H., Ishida, T., The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage. J. Control. Release, 172, 38-47 (2013)
  4. Abu Lila, A.S., Nawata, K., Shimizu, T., Ishida, T., Kiwada, H., Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration. Int. J. Pharm., 456, 235-242 (2013)
  5. Alaaeldin, E., Abu Lila, A.S., Moriyoshi, N., Sarahan, H.A., Ishida, T., Khaled A. Khale, Kiwada, H., The co-delivery of oxaliplatin abrogates the immunogenic response to PEGylated siRNA-lipoplex. Pharm. Res., 30, 2344-2354 (2013)
  6. Ichikawa, K., Asai, T., Shimizu, K., Yonezawa, S., Urakami, T., Miyauchi, H., Kawashima, H., Ishida, T., Kiwada, H., Oku, N., Suppression of immune response by antigen-decorated liposomes encapsulating model agents: A novel strategy for the treatment of allergy. J. Control. Release, 167, 284-289 (2013)
  7. Nagao, A., Abu Lila, A.S., Ishida, T., Kiwada, H., Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: Promise for clinical application. Int. J. Pharm., 441, 395-401 (2013)
  8. Shimizu, T., Ishida, T., Kiwada, H., Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon. Immunobiol. 218, 725-732 (2013)
  9. Ishida, T., Kiwada, H., Anti-polyethyleneglycol (PEG) antibody response to PEGylated substances. Biol. Pharm. Bull., 36, 889-891 (2013)
  10. Ishida, T., Kiwada, H., Alteration of tumor microenvironment for improved delivery and intratumor distribution of nanocarriers. Biol. Pharm. Bull., 36, 692-697 (2013)
  11. 石田竜弘、際田弘志、PEG修飾製剤による抗PEG抗体分泌誘導、ファルマシア:最前線、49, 503-507 (2013)
  12. 石田竜弘、際田弘志、腫瘍内微小環境の能動的制御に基づくsiRNAデリバリー技術の開発とがん治療への展開、薬学雑誌、133, 379-386 (2013)
  13. 石田竜弘、際田弘志、非経口投与製剤の開発と応用 ~次世代型医薬品の新規投与形態の開拓を目指して~(山本 昌監修) 第14章 注射による薬物投与と新規注射剤の開発 2節 腫瘍内微小環境の能動的制御に基づくDDSの開発とがん治療への応用、190-197 (2013)

  

研究費獲得状況

  1. 科学研究費補助金「特別研究員奨励費」(新規)
  2. 研究助成金「永井記念薬学国際交流財団」(新規)
  3. 海外発表促進助成金「日本科学協会」(新規)
  4. 研究助成金「中富健康科学振興財団」(新規)
  5. 研究助成金「大阪コミュニティ財団」(新規)
  6. 科学研究費補助金「基盤B」(継続)
  7. 科学研究費補助金「基盤B」(継続)

   

2012年度

  1. Abu Lila, A.S., Essam Eldin, N., Ichihara, M., Ishida, T., Kiwada, H., Multiple administration of PEG-coated liposomal oxaliplatin enhances its therapeutic efficacy: a possible mechanism and the potential for clinical application. Int. J. Pharm., 438, 176-183 (2012)
  2. Suzuki, T., Ichihara, M., Hyodo, K., Yamamoto, E., Ishida, T., Kiwada, H., Ishihara, H., Kikuchi, H., Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs. Int. J. Pharm., 436, 636-643 (2012)
  3. Shimizu, T., Ichihara, M., Yoshioka, Y., Ishida, T., Nakagawa, S., Kiwada, H., Intravenous administration of PEGylated proteins and PEGylated adenovirus elicits an anti-PEG IgM response. Biol. Pharm. Bull., 35, 1336-1342 (2012)
  4. Abu Lila, A.S., Matsumoto, H., Doi, Y., Nakamura, H., Ishida, T., Kiwada, H., Tumor type dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin. Eur. J. Pharm. Biopharm., 81, 524-531 (2012)
  5. Barichello, J.M., Kizuki, S., Tagami, T., Luiz Alberto Lira Soares, L.A.L., Ishida, T., Kikuchi, H., Kiwada, H., Agitation during lipoplex formation harmonizes the interaction of siRNA to cationic liposomes. Int. J. Pharm., 430, 359-365 (2012)
  6. Abu Lila, A.S., Okada, T., Doi, Y., Ichihara, M., Ishida, T., Kiwada, H., Combination therapy with metronomic S-1 dosing and oxaliplatin-containing PEG-coated cationic liposomes in a murine colorectal tumor model: Synergy or antagonism? Int. J. Pharm., 426, 263-270 (2012)
  7. Tagami, T., Abu Lila, A.S., Matsunaga, M., Moriyoshi, N., Nakamura, H., Nakamura, K., Suzuki, T., Doi, Y., Ishida, T., Kiwada, H., Improved intratumoral delivery of PEG-coated siRNA-lipoplexes by combination with metronomic S-1 dosing in a murine solid tumor model. Drug Deliv. Transl. Res., 2, 77-86 (2012)
  8. Ichihara, M., Moriyoshi, N., Abu Lila, A.S., Ishida, T., Kiwada, H., Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery. in Nanotechnology for Nucleic acid Delivery, Methods in Molecular Biology Oupicky, D. and Ogris, M. (Ed.), Springer, 948, 35-47 (2012)
  9. Tagami, T., Suzuki, T., Matsunaga, M., Nakamura, K., Moriyoshi, N., Ishida, T., Kiwada, H., Anti-angiogenic therapy via cationic liposome-mediated systemic siRNA delivery. Int. J. Pharm., 422, 280-289 (2012)

 

研究費獲得状況

  1. 研究助成金「武田科学振興財団」(新規)
  2. テルモ科学技術振興財団「国際交流助成金」(新規)
  3. 研究交流助成金「金原一郎記念医学医療振興財団」(新規)
  4. 科学研究費補助金「基盤B」(新規)
  5. 研究助成金「高橋産業経済研究財団」(新規)
  6. 科学技術振興財団・研究成果最適展開支援プログラム(A-STEP)探索タイプ(継続)
  7. 科学研究費補助金「挑戦的萌芽研究」(継続)
  8. 科学研究費補助金「基盤B」(継続)
  9. 科学研究費補助金「外国人特別研究員奨励費」(継続)
  10. 科学研究費補助金「若手研究B」(継続)
  11. 平成22-24年度 徳島大学パイロット事業支援プログラム(研究支援事業)「学長裁量経費」(継続)

   

2011年度

  1. 石田竜弘、リポソームDDSの開発研究~トランスレーショナルリサーチの実現を目指して~、薬剤学、71, 315-320 (2011)
  2. Nakamura, K., Abu Lila A., Matsunaga, M., Doi, Y., Ishida, T., Kiwada H., A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA. Mol. Ther., 19, 2040-2047 (2011)
  3. Abu Lila A.S., Ishida, T., Kiwada, H., Cationic liposomes and tumour vasculature targeting: a therapeutic approach that has potential for solid tumours. A book chapter in Lipid Nanocarriers in Cancer Diagnosis and Therapy, Chapter 6, 137-168 (2011) Souto, E.B. (Ed.), i-Smithers - Creative Publishing Solutions
  4. Tagami, T., Suzuki, T., Hirose, K., Barichello, J.M., Yamazaki, N., Asai, T., Oku, N., Ishida, T., Kiwada, H., Argonaute2 is a potential target for siRNA-based cancer therapy for HT1080 human fibrosarcoma. Drug Deliv. and Transl. Res., 1, 277-288 (2011)
  5. 石田竜弘、際田弘志、PEG修飾リポソーム製剤繰り返し投与による血中滞留性低下、C&I Commun., 36, 19-21 (2011)
  6. Ichihara, M., Shimizu, T., Imoto, A., Hashiguchi, Y., Uehara, Y., Ishida, T., Kiwada, H., Anti-PEG IgM response against PEGylated liposomes in mice and rats. Pharmaceutics, 3, 1-11 (2011)
  7. Saito, A., Shimizu, H., Doi, Y., Ishida, T., Fujimura, M., Inoue, T., Kiwada, H., Tominaga, T., Immunoliposomal drug delivery system targeting lectin-like oxidized low density lipoprotein receptor 1 for carotid plaque lesion in rats. J. Neurosurgery., published online June 17, 2011; DOI: 10.3171/2011.5.JNS10227
  8. Barichello, J.M., Kizuki, S., Tagami, T., Asai, T., Ishida, T., Kikuchi, K., Oku, N., Kiwada, H., Agitation during lipoplex formation improves the gene knockdown effect of siRNA. Int. J. Pharm., 410, 153-160 (2011)
  9. Tagami, T., Uehara, Y., Moriyoshi, N., Ishida T., Kiwada, H., Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA. J. Control. Release, 151, 149-154 (2011)
  10. Doi, Y., Ishida, T., Kiwada, H., Breaking the barriers to tumor-targeting via nanocarrier-based drug delivery to the tumor microenvironment. A book chapter in Cancer Targeted Therapy, A book chapter in Neuro-Oncology and Cancer Targeted Therapy, Chapter 5, 141-160 (2010) Gutierrez, L.M. (Ed.), Nova Science Publishers

 

研究費獲得状況

  1. 科学技術振興財団・研究成果最適展開支援プログラム(A-STEP)探索タイプ(新規)
  2. 研究助成金「島原科学振興会」(新規)
  3. 科学研究費補助金「若手研究B」(新規)
  4. 永井記念薬学国際交流財団「Research grant」(新規)
  5. 科学研究費補助金「若手研究A」(継続)
  6. 厚生労働省科学研究費「医療機器開発推進研究事業(若手)」(継続)
  7. 平成22年度徳島大学パイロット事業支援プログラム(研究支援事業)「学長裁量経費」(継続)
  8. 平成23-25年度科学研究費補助金「基盤B」(新規)
  9. 研究助成金「高橋産業経済研究財団」(新規)
  10. 科学研究費補助金・日本学術振興会「特別研究員奨励費」(新規)

 

2010年度

  1. 石田竜弘、生体内動態検討を基盤としたリポソームDDSの開発~第2回日本DDS学会奨励賞(臨床)受賞によせて~、Drug Deliv. Sys., 25, 511-516 (2010)
  2. Ishihara, T., Maeda, T., Sakamoto, H., Takasaki, N., Shigyo, M., Ishida, T., Kiwada, H., Mizushima, Y., Mizushima, T., Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers. Biomacromolecules, 11, 2700-2706 (2010)
  3. Doi, Y., Okada, T., Matsumoto, H., Ichihara, M., Ishida, T., Kiwada, H., Combination therapy of metronomic S-1 dosing with oxaliplatin-containing PEG-coated liposome improves antitumor activity in a murine colorectal tumor model. Cancer Sci., 101, 2470-2475 (2010)
  4. Eto, Y., Yoshioka, Y., Ishida, T., Yao X., Morishige, T., Narimatsu, S., Mizuguchi, H., Mukai, Y., Okada, N., Kiwada, H., Nakagawa, S., Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer. Biol. Pharm. Bull., 25, 149-154 (2010)
  5. Koide, H., Asai, T., Hatanaka, K., Akai, S., Ishii, T., Kenjo, E., Ishida, T., Kiwada, H., Tsukada, H., Oku, N., T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes. Int. J. Pharm., 392, 218-223 (2010)
  6. Abu Lila, A., Ishida, T., Kiwada, H., Targeting anticancer drugs to tumor vasculature using cationic liposomes. Pharm. Res., 27, 1171-1183 (2010)
  7. Tagami, T., Nakamura, K., Shimizu, T., Yamazaki, N., Ishida, T., Kiwada, H., CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes. J. Control. Release, 142, 160-166 (2010)
  8. Abu Lila, A., Doi, Y., Nakamura, K., Ishida, T., Kiwada, H., Sequential administration with oxaliplatin-containing PEG-coated cationic liposomes promotes a significant delivery of subsequent dose into murine solid tumor. J. Control. Release, 142, 167-173 (2010)
  9. Yamazaki, H., Miyake, M., Kamada, N., Nishibayashi, T., Mukai, T., Odomi, M., Ishida, T., Kiwada, H., Co-administration of tacrolimus suppre sses pharmacokinetic modulation of multiple subcutaneously administrated human interferon-alpha in beagle dogs. Drug Metab. Pharmacokinet. 25, 149-154 (2010)
  10. Barichello, J. M., Ishida, T., Kiwada, H., Complexation of siRNA and pDNA with cationic liposomes: The important aspects in lipoplex preparation. A chapter, Liposomes, Methods Mol. Biol., 605, 461-472 (2010)

 

研究費獲得状況

  1. 平成22年度徳島大学パイロット事業支援プログラム(研究支援事業)「学長裁量経費」
  2. 金原一郎記念医学医療振興財団「基礎医学医療研究助成金」
  3. 内藤記念科学振興財団「内藤記念若手研究者海外派遣助成金」
  4. 科学研究費補助金「若手研究A」
  5. 厚生労働省科学研究費「医療機器開発推進研究事業(若手)」
  6. 科学研究費補助金「基盤B」
  7. テルモ科学技術振興財団「国際交流助成金」

 

2009年度

  1. Ishida, T., Kiwada, H., Synergistic antitumor activity of metronomic dosing chemotherapy in combination with liposomal anticancer drug. A book chapter in Anticancer Drugs: Design, Delivery and Pharmacology, Spencer, P. and Holt, W., Ed. Nova Science Publishers (2009)
  2. Ishida, T., Kiwada, H., Unexpected reactions by in vivo application of PEGylated liposomes. “Safety of Nanoparticles: From Manufacturing to Clinical Applications (A volume in the Nanostructure Science and Technology series)" T.J. Webster (Ed.), Chapter 6, p111-130 (2009) Springer Science + Business Media, New York, USA
  3. Abu Lila, A., Ishida, T., Kiwada, H., Recent advances in tumor vasculature targeting using liposomal drug delivery systems. Expert Opin. Drug Deliv., 6, 1297-309 (2009)
  4. Ishihara, T., Takeda, M., Sakamoto, H., Kimoto, A., Kobayashi, C., Takasaki, N., Yuki, K., Tanaka, K., Takenaga, M., Igarashi, R., Maeda, T., Yamakawa, N., Okamoto, Y., Otsuka, M., Ishida, T., Kiwada, H., Mizushima, Y. and Mizushima, T., Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles. Pharm. Res., 26, 2270-2279 (2009)
  5. Yamazaki, H., Miyake, M., Nishibayashi, T., Mukai, T., Odomi, M., Ishida, T., Kiwada, H. Effect of co-administration of tacrolimus on the pharmacokinetics of multiple subcutaneous administered interferon-alpha in rats. Pharm. Res., 26, 1832-1837 (2009)
  6. Abu Lila, A., Kizuki, S., Doi, Y., Suzuki, T., Ishida, T., Kiwada, H., Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model. J. Control. Release, 137, 8-14 (2009)
  7. Tagami, T., Nakamura, K., Shimizu, T., Ishida, T., Kiwada, H., Effect of siRNA in PEG-coated siRNA-lipoplex on the anti-PEG IgM production . J. Control. Release, 137, 234-240 (2009)
  8. Isakari, Y., Sogo, S., Ishida, T., Kawakami, T., Ono, T., Taki, T., Kiwada, H., Gene expression analysis during platelet-like particle production in phorbol myristate acetate-treated MEG-01cells. Biol. Pharm. Bull. 32, 354-358 (2009)
  9. Ishida, T., Shiraga, E., Kiwada, H., Synergistic antitumor activity of metronomic dosing of cyclophosphamide in combination with doxorubicin-containing PEGylated liposomes in a murine solid tumor model. J. Control. Release, 134, 194-200 (2009)
  10. Abu-Lila, A, Suzuki, T., Doi, Y., Ishida, T., Kiwada, H., Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model. J. Control. Release, 134, 18-25 (2009)
  11. Ishida, T., Kiwada, H., Unexpected reactions by in vivo application of PEGylated liposomes. “Safety of Nanoparticles: From Manufacturing to Clinical Applications (A volume in the Nanostructure Science and Technology series)" T.J. Webster (Ed.), Chapter 6, p111-130 (2009) Springer Science + Business Media, New York, USA

 

研究費獲得状況

  1. 科学技術振興機構 平成21年度「シーズ発掘試験A(発掘型)」
  2. 科学研究費補助金「若手研究A」
  3. 厚生労働省科学研究費「医療機器開発推進研究事業(若手)」
  4. 科学研究費補助金「基盤B」
  5. 科学研究費補助金「がん特定研究」
  6. がん研究に係わる特定領域研究・国際交流委員会「研究者海外派遣事業」
  7. 日本学術振興会「国際学会等派遣事業」
  8. 平成21年度教育研究等支援事業「学長裁量経費」

 

2008年度

  1. Tagami, T., Hirose, K., Barichello, J.B., Ishida, T., Kiwada, H., Global gene expression profiling in cultured cells is strongly influenced by treatment with siRNA-cationic liposome complexes. Pharm. Res., 25, 2497-2504 (2008)
  2. Koide, H., Asai, T., Hatanaka, K., Urakami, T., Ishii, T., Kenjo, E., Nishihara, M., Yokoyama, M., Ishida, T., Kiwada, H., Oku, N., Particle size-dependent triggering of accelerated blood clearance phenomenon. Int. J. Pharm., 362, 197-200 (2008)
  3. Barichello, J.M., Yamakawa, N., Kisyuku, M., Handa, H., Shibata, T., Ishida, T., Kiwada, H., Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin. Int. J. Pharm., 357, 199-205 (2008)
  4. Asai, T.,Suzuki, Y., Matsushita, S., Yonezawa, S., Yokota, J., Katanasaka, Y., Ishida, T., Dewa, T., Kiwada, H., Nango, N., Oku, N., Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown. Biochem. Biophys. Res. Commun., 368, 243-248 (2008)
  5. Matsumura-Takeda, K., Ishida, T., Sogo, S., Isakari, Y., Taki, T., Sogo, T., Kiwada, H., Lactoferrin inhibits platelet production from human megakaryocytes in vitro. Biol. Pharm. Bull., 31, 569-573 (2008)
  6. Ishida, T., Kiwada, H., Accelerated blood clearance (ABC) phenomenon upon repeated injection. J. Control. Release, 354, 56-62 (2008)
  7. Ishida, T., Kashima, S., Kiwada, H., The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats. J. Control. Release, 126, 162-165 (2008)
  8. Shiraga, E., Barichello, J.M., Ishida, T., Kiwada, H., A metronomic schedule of cyclophosphamide combined with PEGylated liposomal doxorubicin has a highly antitumor effect in an experimental pulmonary metastatic mouse model. Int. J. Pharm., 353, 65-73 (2008)
  9. 石田竜弘、際田弘志、ポリエチレングリコール修飾リポソーム投与時に生ずるaccelerated blood clearance (ABC)現象、薬学雑誌、128, 233-243 (2008)

 

研究費獲得状況

  1. 科学研究費補助金「基盤B」
  2. 科学研究費補助金「がん特定研究」
  3. 科学研究費補助金「若手B」
  4. 持田記念医学薬学振興財団・研究助成金
  5. 大和証券ヘルス財団・調査研究助成金
  6. テルモ科学技術振興財団・国際交流助成金

 

2007年度

  1. 石田竜弘、際田弘志、ポリマー修飾ナノ微粒子投与による免疫活性化に関する研究、表面、45, 357-371 (2007)
  2. Hatakeyama, H., Akita, H., Ishida, E., Hashimoto, K., Kobayashi, H., Aoki, T., Yasuda, J., Obata, K., Kikuchi, K., Ishida, T., Kiwada, H., Harashima, H., Tumor targeting of doxorubicin by anti MT1-MMP antibody-modified PEG liposomes. Int. J. Pharm., 342, 194-200 (2007)
  3. Ishida, T., Wang X.Y., Shimizu, T., Nawata, K., Kiwada, H., PEGylated liposomes elicit an anti-PEG IgM response in a T-cells independent manner. J. Control. Release, 119, 236-244 (2007)
  4. Wang, X.Y., Ishida, T., Kiwada, H., Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes. J. Control. Release, 119, 236-244 (2007)
  5. Isakari, Y., Harada, Y., Ishikawa, D., Matsumura-Takeda, K., Sogo, S., Ishida, T., Taki, T., Kiwada, H., Efficient gene expression in Megakaryocytic cell line using Nucleofection. Int. J. Pharm., 338, 157-164 (2007).
  6. Atobe, K., Ishida, T., Ishida, E., Hashimoto, K., Kobayashi, H., Yasuda, J., Aoki, T., Obata, K, Kikuchi, H., Akita, H., Asai, T, Harashima, H., Oku, N., Kiwada, H., In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP). Biol. Pharm. Bull., 30, 972-978 (2007)
  7. Nguyen, L.T., Atobe, K., Barichello, J.M., Ishida, T., Kiwada, H., Complex formation with plasmid DNA increases the cytotoxicity of cationic liposomes. Biol. Pharm. Bull., 30, 751-757 (2007)
  8. Tagami, T., Barichello, J.M., Kikuchi, H., Ishida, T., Kiwada, H., The gene-silencing effect of siRNA in cationic lipoplexes is enhanced by incorporating pDNA in the complex. Int. J. Pharm., 333, 62-69 (2007)
  9. 石田竜弘、際田弘志、リポソームと細胞の相互作用(DDSへの応用)、膜、32, 18-24 (2007)
  10. Kobayashi, T., Ishida, T., Okada, Y., Ise, S., Harashima, H., Kiwada, H., Effect of Transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells. Int. J. Pharm., 329, 94-102 (2007)

 

研究費獲得状況

  1. 知的クラスター創成事業
  2. 厚生労働省科学研究費補助金
  3. 科学研究費補助金「がん特定研究」
  4. 科学研究費補助金「若手B」
  5. テルモ科学技術振興財団・国際交流助成金
  6. 山陽放送学術文化財団

 

2006年度

  1. Ishida, T., Atobe, K., Wang, X., Kiwada, H., Accelerated blood clearance of PEGylated liposomes upon repeated injections: Effect of doxorubicin-encapsulation and high-dose first injection. J. Control. Release, 115, 251-258 (2006)
  2. Ishida, T., Ichihara, M., Wang, X., Kiwada, H., Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes. J. Control. Release, 115, 243-250 (2006)
  3. Barichello, J.M., Handa, H., Kisyuku, M., Shibata, T., Ishida, T., Kiwada, H., Inducing effect of liposomalization on the transdermal delivery of hydrocortisone: creation of a drug supersaturated state. J. Control. Release, 115, 94-102 (2006)
  4. Ishida, T., Ichihara, M., Wang X.W., Yamamoto, K., Kimura, J., Majima, E., Kiwada, H., Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes. J. Control. Release, 112, 15-25 (2006)
  5. Dang, F., Li, W., Zhang, L., Jabasini, M., Ishida, T., Kiwada, H., Kaji, N., Tokeshi, M., Baba, Y., Electrophoretic behavior of plasmid DNA in the presence of various intercalating dyes. J. Chromatography A, 1118, 218-225 (2006)
  6. Ishida, T., Li, W., Liu, Z., Kiwada, H., Stimulatory effect of polyethylene glycol (PEG) on gene expression in mouse liver following hydrodynamics-based transfection. J. Gene Med., 8, 324-334 (2006)
  7. Ishida, T., Okada, O., Kobayashi, T., Kiwada, H., Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood. Int. J. Pharm., 309, 94-100 (2006)
  8. Ishida, T., Takanashi, Y., Kiwada, H., Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil. Biol. Pharm. Bull., 29, 397-402 (2006)
  9. 石田竜弘、際田弘志、がん治療を目指した機能性リポソームの開発研究、化学工業、57, 39-43 (2006)

 

研究費獲得状況

  1. 知的クラスター創成事業
  2. 厚生労働省科学研究費補助金
  3. 科学研究費補助金「がん特定研究」
  4. 包括的研究連携(大鵬薬品工業)
  5. 原口記念癌研究助成基金
  6. 花王芸術・科学財団
  7. 住友財団

 

2005年度

  1. Nguyen, L.T., Ishida, T., Kiwada, H., Gene expression in primary cultured mouse hepatocytes with a cationic liposomal vector, TFL-3: Comparison with rat hepatocytes. Biol. Pharm. Bull., 28, 1472-1475 (2005)
  2. Ishida, T., Harada, M., Wang, X.Y., Ichihara, M., Irimura, K., Kiwada, H., Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes. J. Control. Release, 105, 305-317 (2005)
  3. Wang, XY, Ishida, T., Ichihara, M., Kiwada, H., Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats. J. Control.Release, 104, 91-102 (2005)
  4. 石田竜弘、際田弘志、リポソーム応用の新展開 ~人工細胞の開発に向けて~(秋吉一成、辻井 薫編) 第10章 医学薬学でのリポソーム応用 3節 長期血中滞留性リポソーム 2005
  5. 石田竜弘、際田弘志、リポソーム応用の新展開 ~人工細胞の開発に向けて~(秋吉一成、辻井 薫編) 第10章 医学薬学でのリポソーム応用 1節 リポソームと細胞の相互作用、2005
  6. Li, W., Ishida, T., Okada, Y., Oku, N., Kiwada, H., Increased gene expression by cationic liposomes (TFL-3) in lung metastases following intravenous injection. Biol. Pharm. Bull., 21, 701-706 (2005)
  7. Tsuchiya, K., Kanematsu, Y., Yoshizumi, M., Ohnishi, H., Kirima, K., Izawa, Y., Shikishima, M., Ishida, T., Kondo, S., Kagami, S., Takiguchi, Y., Tamaki, T., Nitrite is an alternative source of NO in vivo. Am. J. Physiol. Heart Circ. Physiol. 288: H2163-2170 (2005)

 

研究費獲得状況

  1. 厚生労働省科学研究費補助金
  2. 包括的研究連携(大鵬薬品工業)
  3. 科学研究費補助金、若手B
  4. 黒住医学研究振興財団

 

2004年度

  1. Ishida, T., Ichikawa, T., Ichihara, M., Sadzuka, Y., Kiwada, H., Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice. J. Control. Release, 95, 403-412 (2004)
  2. 石田竜弘、高梨吉裕、際田弘志、能脊髄腔内直接投与可能なDDSの開発とその脳保護効果、薬事、1333-1338 (2004)
  3. 石田竜弘、脳脊髄腔内直接投与可能なDDSの開発とその脳保護効果の検討、薬学雑誌、124, 541-547 (2004)
  4. 石田竜弘、際田弘志、ポリエチレングリコール表面修飾リポソームの繰り返し投与時に発現するaccelerated blood clearance (ABC)現象、Drug Deliv. Sys., 495-510 (2004)
  5. Li, W., Ishida, T., Tachibana R., Almofti, M.R., Wang X., Cell type-specific gene expression, mediated by TFL-3, a cationic liposomal vector, is controlled by a post-transcription process of delivered plasmid DNA. Int. J. Pharm., 276, 67-74 (2004)
  6. Tachibana, R., Ide, N., Shinohara, Y., Harashima, H., Hunt, C.A., Kiwada, H., An assessment of relative transcriptional availability from nonviral vectors. Int. J. Pharm., 270, 315-321 (2004)

 

研究費獲得状況

  1. 科学研究費補助金「若手B」
  2. 原口記念癌研究助成基金
  3. 薬理研究会
  4. 佐川がん研究助成振興財団

 

2003年度

  1. Tachibana, R., Futaki, S., Harashima, H., Kiwada, H., pH-sensitive liposomes in nuclear targeting of macromolecules. Methods in Enzymol., 372, 349-361 (2003)
  2. Almofti, M.R., Harashima, H., Shinohara, Y., Almofti, A., Li, W.H., Kiwada, H., Lipoplex size determines lipofection efficiency with or without serum. Mol. Mem. Biol., 20, 35-43 (2003)
  3. Almofti, M.R., Harashima, H., Shinohara, Y., Almofti, A., Li, W.H., Baba, Y., Kiwada, H., Cationic liposome-mediated gene delivery: Biophysical study and mechanism of internalization. Arch. Biochem. Biophys., 410, 246-253 (2003)
  4. Nguyen, N.L., Ishida, T., Ukitsu, S., Li, W.H., Tachibana, R., Kiwada, H., Culture-time dependent gene expression in isolated primary cultured rat hepatocytes by transfection with a cationic liposomal vector, TFL-3. Biol. Pharm. Bull., 26, 880-885 (2003)
  5. Ishida, T., Masuda, K., Ichikawa, T., Ichihara, M., Irimura, K., Kiwada, H., Accelerated clearance of a second injection of PEGylated liposomes in mice. Int. J. Pharm., 255, 167-174 (2003)
  6. Ishida, T., Maeda, R., Ichihara, M., Irimura, K., Kiwada, H., Accelerated clearance of PEGylated liposomes in rats after repeated injections. J. Control. Release, 88, 35-42 (2003)
  7. 石田竜弘、際田弘志、DDS研究の現状、科学フォーラム、2003-12, 22-28 (2003)
  8. 石田竜弘、機能性リポソームの開発とその癌治療への応用、薬事、45, 1125-1132 (2003)
  9. 石田竜弘、癌と人、30, 28-29 (2003)

 

  1. 科学研究費補助金「若手B」
  2. 日本科学協会
  3. 薬学研究奨励財団
  4. 上原記念生命科学財団
  5. 臨床薬理研究財団
最終更新日:2017年10月16日