研究業績

2000年~現在

116) Imanishi M, Tomita S, Ishizawa K, Kihira Y, Ueno M, Izawa-Ishizawa Y, Ikeda Y, Yamano N, Tsuchiya K, Tamaki T. Smooth muscle cell-specific Hif-1α deficiency suppresses angiotensin II-induced vascular remodelling in mice. Cardiovasc Res. 102, 460-468, 2014.

 

115) Imamura Y, Tomita S, Imanishi M, Kihira Y, Ikeda Y, Ishizawa K, Tsuchiya K, Tamaki T. HIF-2α/ARNT complex regulates hair development via induction of p21Waf1/Cip1 and p27Kip1. FASEB J. 28, 2517-2524, 2014.

 

114) Ishizawa K, Izawa-Ishizawa Y, Yamano N, Urushihara M, Sakurada T, Imanishi M, Fujii S, Nuno A, Miyamoto L, Kihira Y, Ikeda Y, Kobori H, Tsuchiya K, Tamaki T. Nitrosonifedipine Ameliorates the Progression of Type 2 Diabetic Nephropathy by Exerting Antioxidative Effects. Plos One 9, e8635, 2014.

 

113) Shigenaga A, Ogura K, Hirakawa H, Yamamoto J, Ebisuno K, Miyamoto L, Ishizawa K, Tsuchiya K, Otaka A. Design and synthesis of hypoxia-responsive amino acid which causes prptide bond cleavage in hypoxic cells. Peptide Science 135-136, 2013.

 

112) Ikeda Y, Enomoto H, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Tamaki T. Dietary iron restriction inhibits progression of diabetic nephropathy in db/db mice. Am J Physiol Renal Pathol 304, F1028-F1036, 2013.

 

111) Ikeda Y, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Yoshida S, Aihara K, Tsuchiya K, Tamaki T. Bovine milk-derived lactoferrin exerts proangiogenic effects via an Src-Akt-eNOS-dependent manner in response to ischemia. J Cardiovasc. Pharmacol. 61, 423-429, 2013.

 

110) Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K. Leptin Activates Hepatic 5'-AMP-activated Protein Kinase through Sympathetic Nervous System and α1-Adrenergic Receptor: A POTENTIAL MECHANISM FOR IMPROVEMENT OF FATTY LIVER IN LIPODYSTROPHY BY LEPTIN. J Biol Chem. 287, 40441-40447, 2012.

 

109) Shigenaga A, Ogura K, Hirakawa H, Yamamoto J, Ebisuno K, Miyamoto L, Ishizawa K, Tsuchiya K, Otaka A. Development of a reduction-responsive amino acid that induces peptide bond cleavage in hypoxic cells. Chembiochem. 13, 968-971, 2012.

 

108) Miyamoto L, Watanabe M, Kono M, Matsushita T, Hattori H, Ishizawa K, Nemoto H, Tsuchiya K. Cytotoxicity evaluation of symmetrically branched glycerol trimer in human hepatocellular carcinoma HepG2 cells. J Toxicol Sci. 37, 1059-1063, 2012.

 

107) Sakurada T, Ishizawa K, Imanishi M, Izawa-Ishizawa Y, Fujii S, Tominaga E, Tsuneishi T, Horinouchi Y, Kihira Y, Ikeda Y, Tomita S, Aihara K, Minakuchi K, Tsuchiya K, Tamaki T. Nitrosonifedipine ameliorates angiotensin II-induced vascular remodeling via antioxidative effects. Naunyn-Schmiedeberg's Arch Pharmacol, 386, 29-39, 2013.

 

106) Izawa-Ishizawa Y, Ishizawa K, Sakurada T, Imanishi M, Miyamoto L, Fujii S, Taira H, Kihira Y, Ikeda Y, Hamano S, Tomita S, Tsuchiya K, Tamaki T. Angiotensin II receptor blocker improves tumor necrosis factor-α-induced cytotoxicity via antioxidative effect in human glomerular endothelial cells. Pharmacology, 90, 324-331, 2012.

 

105) Miyamoto L, Watanabe M, Tomida Y, Kono M, Fujii S, Matsushita T, Hattori H, Ishizawa K, Nemoto H, Tsuchiya K. Acute Oral Toxicity Evaluation of Symmetrically

Branched Glycerol Trimer in ddY Mice. J Toxicol Sci. 37, 1253-1259, 2012.

 

104) Nemoto H, Kamiya M, Nakamoto A, Matsushita T, Matsumura K, Hattori H, Kawamura T, Taoka C, Abe S, Ishizawa K, Miyamoto L, Tsuchiya K. Synthesis of highly water-soluble fibrate derivatives via BGLation. Bioorg Med Chem Lett. 22, 6425-6428, 2012.

 

103) Nemoto H, Katagiri A, Kamiya M, Kawamura T, Matsushita T, Matsumura K, Itou T, Hattori H, Tamaki M, Ishizawa K, Miyamoto L, Abe S, Tsuchiya K. Synthesis of Paclitaxel-BGL Conjugates. Bioorg Med Chem. 20, 5559-5567, 2012.

 

102) Ikeda Y, Aihara KI, Yoshida S, Iwase T, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Sata M, Akaike M, Kato S, Matsumoto T, Tamaki T. Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMPK-eNOS signaling pathway. J Biol Chem. 287, 34256-34263, 2012.

 

101) Ikeda Y, Tajima S, Izawa-Ishizawa Y, Kihira Y, Ishizawa K, Tomita S, Tsuchiya K, Tamaki T. Estrogen regulates hepcidin expression via GPR30-BMP6-dependent signaling in hepatocytes. PLoS One. 7, e40465, 2012.

 

100) Tajima S, Ikeda Y, Sawada K, Yamano N, Horinouchi Y, Kihira Y, Ishizawa K, Izawa-Ishizawa Y, Kawazoe K, Tomita S, Minakuchi K, Tsuchiya K, Tamaki T. Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and obese and type 2 diabetes KKAy mice. Am.J. Physiol. Endocrinol. Metab. 302(1):E77-86, 2012.

 

99) KIhira Y, Yamamo N, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T, Tomita S. Basic fibroblast growth factor regulates glucose metabolism throuth glucose transporter 1 induced by hypoxia-inducible factor-1α in adipocytes. Int J Biochem Cell Biol. 43,1602-11,2011.

 

98) Ishizawa K, Yoshizumi M, Kawai Y, Terao J, Kihira Y, Ikeda Y, Tomita S, Minakuchi K, Tsuchiya K, Tamaki T. Pharmacology in health food:metabolism of quercetin in vivo and its protective effect against arteriosclerosis. J. Pharmacol. Sci. 115, 466-470, 2011.

 

97) Fukuhara Y, Tsuchiya K, Horinouchi Y, Tajima S, Kihira Y, Hamano S, Kawazoe K, Ikeda Y, Ishizawa K, Tomita S, Tamaki T. Protective effect of photadegradation product of nifedipine against tumor necrosis factor alpha-induced oxidative stress in human glomerular endothelial cells. J. Med Invest. 58m, 118-126, 2011.

 

96) Horinouchi Y, Tsuchiya K, Taoka C, Tajima S, Kihira Y, Matsuda Y, Shishido K, Yoshida M, Hamano S, Kawazoe K, Ikeda Y, Ishizawa K, Tomita S, Tamaki T. Antioxidant effects of photodegradation product of nifedipine. Chem. Pharm. Bull. 59, 208-214, 2011.

 

95) Tomita S, Kihira Y, Imanishi M, Fukuhara Y, Imamura Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T. Inflammatory responses of Hif-1a in T cells observed in development of vascular remodeling. J.Pharmacol. Sci. 115, 433-439, 2011.

 

94) Ikeda Y, Tajima S, Yoshida S, Yamano N, Kihara Y, Ishizawa K, Aihara K, Tomita S, Tsuchiya K, Tamaki T. Deferoxamine promotes angiogenesis via the activation of vascular endothlial cell function. Atheroscleosis. 215, 339-347, 2011.

 

93) Yanagawa H, Terao J, Takeda E, Takaishi Y, kashiwada Y, Kawazoe K, Fushitani S, Tsuchiya K, Yamauchi A, Sato C, Irahara M. Consultation clinics for complementary and alternative medicine at Japanese university hospitals:An analysis at Tokushima University Hospital Exp. Therap.Med. 1, 481-483, 2010.

 

92) Tajima S, Tsuchiya K, Horinouchi Y, Ishizawa K, Ikeda Y, Kihira Y, Shono M, Kawazoe K, Tomita S. and Tamaki T. Effect of angiotensin Ⅱon iron-transporting protein expression and subsequent intracellular labile iron concentration in human glomerular endothelial cells. Hypertens Res. 33,713-721, 2010.

 

91) Tsuchiya K, Tomita S, Ishizawa K, Abe S, Ikeda Y, Kihira Y, Tamaki T. Dietary nitrite ameliorates renal injury in L-NAME-induced hypertensive rats. Nitric Oxide. 22, 98-103, 2010.

 

90) Ishizawa K., Izawa-Ishizawa Y., Dorjsuren N., Miki E., KihiraY.,Ikeda Y.,Hamano S.,Kawazoe K.,Minakuchi K.,Tomita S.,Tsuchiya K.,Tamaki T. Angiotensin II receptor blocker attenuates PDGF-induced mesangial cell migration in a receptor-independent manner. Nephrol. Dial. Transplant. 25, 364-372, 2010.

 

89) Kawazoe H., Takaoka K., Shibata H., Arakaki N., Higuchi T., Negayama K., Houchi H., Tsuchiya K., Takiguchi Y. Comparison of antibacterial activity of fluoroquinolones with their sucralfate-complexes against clinically-isolated bacteria. J Health Sci. 55, 790-795, 2009.

 

88) Ishizawa K, Dorjsuren N, Izawa-Ishizawa Y, Sugimoto R, Ikeda Y, Kihira Y, Kawazoe K, Tomita S, Tsuchiya K, Minakuchi K, Tamaki T. Inhibitory effects of adiponectin on platelet-derived growth factor-induced mesangial cell migration. J Endocrinol. 202, 309-316, 2009.

 

87) Motobayashi Y, Izawa-Ishizawa Y, Ishizawa K, Orino S, Yamaguchi K, Kawazoe K, Hamano S, Tsuchiya K, Tomita S, Tamaki T. Adiponectin inhibits insulin-like growth factor-1-induced cell migration by the suppression of extracellular signal-regulated kinase 1/2 activation, but not Akt in vascular smooth muscle cells. Hypertens Res. 32, 188-193, 2009.

 

86) Ishizawa K, Izawa-Ishizawa Y, Ohnishi S, Motobayashi Y, Kawazoe K, Hamano S, Tsuchiya K, Tomita S, Minakuchi K, Tamaki T. Drug discovery for overcoming chronic kidney disease (CKD): development of drugs on endothelial cell protection for overcoming CKD. J Pharmacol Sci. 109, 14-19, 2009.

 

85) Ishizawa K, Izawa-Ishizawa Y, Ohnishi S, Motobayashi Y, Kawazoe K, Hamano S, Tsuchiya K, Tomita S, Minakuchi K, Tamaki T. Quercetin glucuronide inhibits cell migration and proliferation by platelet-derived growth factor in vascular smooth muscle cells. J Pharmacol Sci. 109, 257-264, 2009.

 

84) Fukuzawa K., Shibata A., Okamura C., Fujiwara Y., Akai K., Tsuchiya K., Tokumura A., Bebicki J.M. Measurement of lipid hydroperoxides by the ferric-xylenol orange method: (1) Characteristics of the ferric-xylenol orange/membrane phosphatidylcholine complex. J.Nutr.Sci.Vitaminol. 55, 9-14, 2009.

 

83) Ohnishi H, Iwanaga S, Kawazoe K, Ishizawa K, Orino S, Tomita S, Tsuchiya K, Kanematsu Y, Harada N, Mori K, Ishikawa Y, Tamaki T. Effect of iron-quercetin complex on reduction of nitrite in vitro and in vivo systems. J Agric Food Chem.56, 10092-10098, 2008.

 

82) Kanematsu Y, Yamaguchi K, Ohnishi H, Motobayashi Y, Ishizawa K, Izawa Y, Kawazoe K, Kondo S, Kagami S, Tomita S, Tsuchiya K, Tamaki T. Dietary doses of nitrite restore the circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats. Am J Physiol Renal Physiol. 295, F1457-F1462, 2008.

 

81) Abe M, Takiguchi Y, Ichimaru S, Kaji S, Tsuchiya K, Wada K. Different effect of acute treatment with rosiglitazone on rat myocardial ischemia/reperfusion injury by administration method. Eur J Pharmacol. 589, 215-219, 2008.

 

80) Abe M, Takiguchi Y, Ichimaru S, Tsuchiya K, Wada K. Comparison of the protective effect of N-acetylcysteine by different treatments on rat myocardial ischemia-reperfusion injury. J Pharmacol Sci. 106, 571-577, 2008.

 

79) Izawa Y, Yoshizumi M, Ishizawa K, Fujita Y, Kondo S, Kagami S, Kawazoe K, Tsuchiya K, Tomita S, Tamaki T. Big mitogen-activated protein kinase 1 (BMK1)/extracellular signal regulated kinase 5 (ERK5) is involved in platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell migration. Hypertens Res. 30, 1107-1117, 2007.

 

78) Sanae Iwana, Tomoya Kawazoe, Hwan Ki Park, Koichiro Tsuchiya, Koji Ono, Kazuko Yorita, Takashi Sakai, Takenori Kusumi, Kiyoshi Fukui Chlorpromazine oligomer is a potentially active substance that inhibits human D-amino acid oxidase, product of a susceptibility gene for schizophrenia. Journal of Enzyme Inhibition and Medicinal Chemistry, 23, 901-911, 2008.

 

77) Nobuko Akiyama, Ikuo Nakanishi, Kei Ohkubo, Kazue Satoh, Koichiro Tsuchiya, Takeshi Nishikawa, Shunichi Fukuzumi, Nobuo Ikota, Toshihiko Ozawa, Masafumi Tsujimoto and Shunji Natori A Long-lived o-Semiquinone Radical Anion is Formed from N-?-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD), an Insect-derived Antibacterial Substance J Biochem.142, 41-48, 2007.

 

76) Shinji Abe, Hideki Ohnishi, Koichiro Tsuchiya, Keisuke Ishizawa, Mayumi Torii, Yasuhisa Kanematsu, Kazuyoshi Kawazoe, Kazuo Minakuchi, Toshiaki Tamaki Calcium and Reactive Oxygen Species Mediated Zn2+-Induced Apoptosis in PC12 Cells J Pharmacol Sci. 102, 103-111, 2006.

 

75) Kawai Y., Kiyokawa H., Kimura Y., Kato K., Tsuchiya K., and Terao J. Hypochlorous acid-derived modification of phospholipids: characterization of aminophospholipids as regulatory molecules for lipid peroxidation Biochemistry, 45, 14201-14211, 2006.

 

74) Nakagawa H, Takaishi Y, Tanaka N, Tsuchiya K, Shibata H, Higuti T. Chemical constituents from the peels of Citrus sudachi. J Nat Prod. 69, 1177-1179, 2006.

 

73) Ali N, Yoshizumi M, Yano S, Sone S, Ohonishi H, Ishizawa K, Kanematsu Y, Tsuchiya K, Tamaki T. The Novel Src Kinase Inhibitor M475271 Inhibits VEGF-Induced Vascular Endothelial-Cadherin and beta-Catenin Phosphorylation but Increases Their Association. J Pharmacol Sci. 102, 112-120, 2006.

 

72) Kanematsu Y, Tsuchiya K, Ohnishi H, Motobayashi Y, Izawa Y, Ishihara M, Ishizawa K, Abe S, Kawazoe K, Tamaki T. Effects of angiotensin II type 1 receptor blockade on the systemic blood nitric oxide dynamics in Nomega-nitro-L-arginine methyl ester-treated rats. Hypertens Res. 29, 369-374, 2006.

 

71) Ramos FA, Takaishi Y, Shiritori M, Kawaguchi Y, Tsuchiya K, Shibata H, Higuti T, Tadokoro T, Takeuchi M. Antibacterial and antioxidant activities of quercetin oxidation products from yellow onion (Allium cepa) skin J. Agric. Food Chem. 54 (10), 3551 -3557, 2006.

 

70) Takiwaki H, Tsuchiya K, Fujita M, Miyaoka Y. Thioridazine induces immediate and delayed erythema in photopatch test Photochem. Photobiol. 82, 523-526, 2006.

 

69) Fujita Y, Yoshizumi M, Izawa Y, Ali N, Ohnishi H, Kanematsu Y, Ishizawa K, Tsuchiya K, Tamaki T. Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferation. Endocrinology. 147, 1377-1385, 2006.

 

68) Fujita Y, Izawa Y, Ali N, Kanematsu Y, Tsuchiya K, Hamano S, Tamaki T, Yoshizumi M. Pramipexole protects against H(2)O(2)-induced PC12 cell death. Naunyn Schmiedebergs Arch Pharmacol. 372, 257-266, 2006.

 

67) Kondo S, Shimizu M, Urushihara M, Tsuchiya K, Yoshizumi M, Tamaki T, Nishiyama A, Kawachi H, Shimizu F, Quinn MT, Lambeth DJ, Kagami S. Addition of the Antioxidant Probucol to Angiotensin II Type I Receptor Antagonist Arrests Progressive Mesangioproliferative Glomerulonephritis in the Rat. J Am Soc Nephrol. 17, 783-794, 2006.

 

66) Ishizawa K, Izawa Y, Ito H, Miki C, Miyata K, Fujita Y, Kanematsu Y, Tsuchiya K, Tamaki T, Nishiyama A, Yoshizumi M. Aldosterone Stimulates Vascular Smooth Muscle Cell Proliferation Via Big Mitogen-Activated Protein Kinase 1 Activation. Hypertension. 46, 1046-1052, 2005.

 

65) Izawa Y, Yoshizumi M, Fujita Y, Ali N, Kanematsu Y, Ishizawa K, Tsuchiya K, Obata T, Ebina Y, Tomita S, Tamaki T. ERK1/2 activation by angiotensin II inhibits insulin-induced glucose uptake in vascular smooth muscle cells. Exp Cell Res. 308, 291-299, 2005.

 

64) Tsuchiya K, Akai K, Tokumura A, Abe S, Tamaki T, Takiguchi Y, Fukuzawa K. Oxygen radicals photo-induced by ferric nitrilotriacetate complex. Biochim Biophys Acta. 1725, 111-119, 2005.

 

63) Fujita Y, Tsuchiya K, Abe S, Takiguchi Y, Kubo SI, Sakurai H. Estimation of the age of human bloodstains by electron paramagnetic resonance spectroscopy: Long-term controlled experiment on the effects of environmental factors. Forensic Sci Int. 152, 39-43, 2005.

 

62) Ali N, Yoshizumi M, Fujita Y, Izawa Y, Kanematsu Y, Ishizawa K, Tsuchiya K, Yano S, Sone S, Tamaki T. A Novel Src Kinase Inhibitor, M475271, Inhibits VEGF-Induced Human Umbilical Vein Endothelial Cell Proliferation and Migration. J Pharmacol Sci. 98, 130-141, 2005.

 

61) K. Tsuchiya, Y. Kanematsu, M. Yoshizumi, H. Ohnishi, K. Kirima, Y. Izawa, M. Shikishima, T. Ishida, S. Kondo, S. Kagami, Y. Takiguchi, Toshiaki Tamaki Nitrite is an alternative source of NO in vivo Am J Physiol Heart Circ Physiol. 288, H2163-H2170, 2005.

 

60) Okamoto M, Tsuchiya K, Kanematsu Y, Izawa Y, Yoshizumi M, Kagawa S, Tamaki T. Nitrite-derived nitric oxide formation following ischemia-reperfusion injury in kidney. Am J Physiol Renal Physiol. 288, F182-F187, 2005.

 

59) Koichiro Tsuchiya, Yoshiharu Takiguchi, Masumi Okamoto, Yuki Izawa, Yasuhisa Kanematsu, Masanori Yoshizumi, Toshiaki Tamaki Formation of systemic hemoglobin-nitric oxide complex (HbNO) from dietary nitrite J Pharmacol Sci. 96, 395-400, 2004.

 

58) Kaori Akai, Koichiro Tsuchiya, Akira Tokumura, Kentaro Kogure, Satoru Ueno, Akira Shibata, Toshiaki Tamaki, Kenji Fukuzawa Ability of ferric nitrilotriacetate complex with three pH-dependent conformations to induce lipid peroxidation Free Radic. Res. 38, 951-962, 2004.

 

57) Kyaw M, Yoshizumi M, Tsuchiya K, Izawa Y, Kanematsu Y, Fujita Y, Ali N, Ishizawa K, Yamauchi A, Tamaki T. Antioxidant Effects of Stereoisomers of N-Acetylcysteine (NAC), L-NAC and D-NAC, on Angiotensin II-Stimulated MAP Kinase Activation and Vascular Smooth Muscle Cell Proliferation. J Pharmacol Sci. 95, 483-486, 2004.

 

56) M.Kyaw, M.Yoshizumi, K.Tsuchiya, Y.Suzaki, Y.Kanematsu, T.Tamaki Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases Acta Pharmacol. Sin. 25, 977-985, 2004.

 

55) Suzaki Y, Yoshizumi M, Kagami S, Nishiyama A, Ozawa Y, Kyaw M, Izawa Y, Kanematsu Y, Tsuchiya K, Tamaki T. BMK1 is activated in glomeruli of diabetic rats and in mesangial cells by high glucose conditions. Kidney Int. 65, 1749-1760, 2004.

 

54) K. Ishizawa, M. Yoshizumi, K. Tsuchiya, H. Houchi, K. Minakuchi, S. Kagami, M. Hirose, T. Tamaki Dual effects of endothelin-1(1-31) to induce mesangial cells migration and facilitate monocyte recruitmente through MCP-1 production by mesangial cells. Hypertension Res. 27, 433-440, 2004.

 

53) Ali N, Yoshizumi M, Tsuchiya K, Kyaw M, Fujita Y, Izawa Y, Abe S, Kanematsu Y, Kagami S, Tamaki T. Ebselen inhibits p38 mitogen-activated protein kinase-mediated endothelial cell death by hydrogen peroxide. Eur J Pharmacol. 485, 127-135, 2004.

 

52) Yoshizumi M, Fujita Y, Izawa Y, Suzaki Y, Kyaw M, Ali N, Tsuchiya K, Kagami S, Yano S, Sone S, Tamaki T. Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells. Exp Cell Res. 292, 1-10, 2004.

 

51) Yoshizumi M, Fujita Y, Izawa Y, Suzaki Y, Kyaw M, Ali N, Tsuchiya K, Kagami S, Yano S, Sone S, Tamaki T. Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells. Exp Cell Res. 292, 1-10, 2004.

 

50) Yoshizumi M, Fujita Y, Izawa Y, Suzaki Y, Kyaw M, Ali N, Tsuchiya K, Kagami S, Yano S, Sone S, Tamaki T. Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells. Exp Cell Res. 292, 1-10, 2004.

 

49) Hasegawa T., Bando A., Tsuchiya K., Abe S., Okamoto M., Kirima K., Ueno S., Yoshizumi M., Houchi H., Tamaki T. Enzymatic and nonenzymatic formation of reactive oxygen species from 6-anilino-5,8-quinolinequinone Biochim. Biophys. Acta 1670, 19-27. 2004.

 

48) Yoshizumi M, Abe J, Tsuchiya K, Berk BC, Tamaki T. Stress and vascular responses: atheroprotective effect of laminar fluid shear stress in endothelial cells: possible role of mitogen-activated protein kinases. J Pharmacol Sci. 91, 172-176, 2003.

 

47) Kogure K, Tsuchiya K, Abe K, Akasu M, Tamaki T, Fukuzawa K, Terada H. Direct radical scavenging by the bisbenzylisoquinoline alkaloid cepharanthine. Biochim Biophys Acta. 1622, 1-5, 2003.

 

46) Tsuchiya K., Kirima K., Yoshizumi M., Tamaki T. New methods to evaluate endotherial function: Evaluation of endotherial function by hemoglobin-nitric oxide complex using electron paramagnetic resonance spectroscopy J. Pharmacol. Sci. 93, 417-422, 2003

 

45) K. Kirima, K. Tsuchiya, H. Sei, T. Hasegawa, M. Shikishima, Y. Motobayashi, K. Morita, M. Yoshizumi, and T. Tamaki Evaluation of systemic blood NO dynamics by EPR spectroscopy: HbNO as an endogenous index of NO Am J Physiol Heart Circ Physiol, 285, H589-H596, 2003.

 

Y.Ozawa, T.Hasegawa, K.Tsuchiya, M.Yoshizumi, T.Tamaki Effect of endothelin-1(1-31) on the renal resostance vessels J. Med. Invest. 50: 87-94, 2003.

 

44) Azuma M., Houchi H., Nishisako H., Ishizawa K., Tsuchiya K., Teraoka K., Ikehara T., Kusumi T., Minakuchi K. Inhibitory action of novel arginine derivative on catecholamine secretion evoked by acetylcholine from cultured bovine adrenal chromaffin cells J. Cardiovasc. Pharmacol. 42, S15-S18, 2003.

 

43) Didem DELIORMAN ORHAM, Erdem YESILADA, Fatma ERGUN, Koichiro TSUCHIYA, Yoshihisa TAKAISHI The antioxidant activity of the extracts and fractions from carduus nutans l. J. Fac. Pharm. Gazi 19, 61-66, 2002.

 

42) Tsuchiya K, Kirima K, Yoshizumi M, Houchi H, Tamaki T, Mason RP. The role of thiol and nitrosothiol compounds in the NO-forming reactions of the iron-MGD complex. Biochem J 367, 771-779, 2002.

 

41) Yoshizumi M, Kogame T, Suzaki Y, Fujita Y, Kyaw M, Kirima K, Ishizawa K, Tsuchiya K, Kagami S, Tamaki T. Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells. Br J Pharmacol. 136, 1023-1032, 2002.

 

40) Yoshizumi M, Tsuchiya K, Suzaki Y, Kirima K, Kyaw M, Moon JH, Terao J, Tamaki T. Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway. Biochem Biophys Res Commun. 293, 1458-1465, 2002

 

39) Suzaki Y, Yoshizumi M, Kagami S, Koyama AH, Taketani Y, Houchi H, Tsuchiya K, Takeda E, Tamaki T. Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults J Biol Chem. 277, 9614-21, 2002.

 

38) K.Ishizawa, M.Yoshizumi, K.Tsuchiya, E.Takishita, Y.Nakaya, K.Kishi, Y.Ebina, H.Houchi, K.Minakuchi, T.Tamaki Effects of losartan in combination with or without exercise on insulin resistance in Otsuka Long-Evans Tokushima Fatty rats. Eur. J. Pharmacol. 430, 359-367, 2001.

 

37) Yoshizumi M, Tsuchiya K, Tamaki T. ]Signal transduction of reactive oxygen species and mitogen-activated protein kinases in cardiovascular disease. J Med Invest. 1-2, 11-24, 2001.

 

36) Yoshizumi M, Tsuchiya K, Kirima K, Kyaw M, Suzaki Y, Tamaki T. Quercetin inhibits Shc- and phosphatidylinositol 3-kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells. Mol. Pharmacol. 60, 656-665, 2001.

 

35) T.Nakamura, H.Houchi, A.Minami, S.Sakamoto, K.Tsuchiya, Y.Niwa, K.Minakuchi, Y.Nakaya Endothelium-dependent relaxation by cilostazol, a phosphodiesteras III inhibitor, on rat throracic aorta. Life Science 69, 1709-1715, 2001.

 

34) Kyaw M., Yoshizumi M., Tsuchiya, K., Kirima, K., Tamaki T. Antioxidants inhibit JNK and p38 MAPK activation but not ERK ? activation by angiotensin II in rat aortic smooth muscle cells Hypertens. Res. 24, 251-261, 2001.

 

33) K.Kirima, K.Tsuchiya, M.Yoshizumi, T.Kameda, H.Houchi, M.Azuma, T.Tamaki Electron paramagnetic resonance study on free radical scavenging and/or generating activity of dopamine-4-O-sulfate. Chem. Pharm. Bull. 49, 576-580, 2001

 

32) Rusyn I, Kadiiska MB, Dikalova A, Kono H, Yin M, Tsuchiya K, Mason RP, Peters JM, Gonzalez FJ, Segal BH, Holland SM, Thurman RG. Phthalates rapidly increase production of reactive oxygen species in vivo: role of kupffer cells. Mol. Pharmacol. 59, 744-750, 2001.

 

31) Yesilada E., Tsuchiya K., Takaishi Y., Kawazoe K. Isolation and characterization of free radical scavenging flavonoid glycosides from the flowers of Spartium junceum by activity-guided fractionation J. Ethnopharmacology 73, 471-478, 2000

 

30) Naoko Okishima, Masanori Yoshizumi, Koichiro Tuchiya, .Ping Cui, Hiroko Kitamura, Toshiaki Tamaki, Hiroshi Kido. Determination of the levels of novel 31-amino acid endothelins and endothelins in human lungs. Life Science 68, 2073-2080, 2001

 

29) D. Inui, M. Yoshizumi, Y. Suzaki, K. Kirima, K. Tsuchiya, H. Houchi, S. Kagami, and T. Tamaki. Effect of endothelin-1(1-31) on p38 mitogen-activated protein kinase in cultured human mesangial cells. Life Science 68, 635-645, 2000.

 

28) Y.Ozawa, H.Houchi, K.Teraoka, M.Azuma, T.Kamimura, M.Yoshizumi, K.Tsuchiya, T.Tamaki, K.Minakuchi Long-term regulation of catecholamine formation by ouabain in cultured bovine adrenal chromaffin cells. J. Cardiovasc. Pharmacol. 36: S15-S18, 2000

 

27) K.Tsuchiya, M.Yoshizumi, H.Houchi, R.P.Mason Nitric oxide-forming reaction between the Iron-N-Methyl-D-glucamine Dithiocarbamate complex and nitrite. J. Biol. Chem. 275, 1551-1556, 2000.

 

~2000年

 

26) M.Yoshizumi, D.Inui, K.Kirima, K.Tsuchiya, H.Houchi, M.Azuma, H.Yasuoka, H.Kido and T.Tamaki. Comparison of the effects of endothelin-1,-2 and -3(1-31) on changes in [Ca2+]i in human coronary artery smooth muscle cells. Jpn. J. Pharmacol. 81, 298-304, 1999.

 

25) K.Tsuchiya, Jin-Jie Jiang, M.Yoshizumi, T.Tamaki, H.Houchi, K.Minakuchi, K. Fukuzawa, R.P. Mason. Nitric oxide-forming reactions of the water-soluble nitric oxide spin-trapping agent, MGD. Free Radic. Biol. Med. 27, 347-355, 1999

 

24) D.Inui, M.Yoshizumi, N.Okishima, H.Houchi, K.Tsuchiya, H.Kido, and T.Tamaki. Mechanism of endothelin-1-(1-31)-induced calcium signaling in human coronary artery smooth muscle cells. Am. J. Physiol. 276, E1067-E1072, 1999

 

23) Y.Ozawa, M.Yoshizumi, D.Inui, K.Tsuchiya, H.Houchi, T.Tamaki, K.Minakuchi. Plasma levels of free and sulfoconjugated catecholamines in patients with atherosclerosis. Biol. Pharm. Bull. 22, 657-659, 1999.

 

22) Y.Ozawa, M.Yoshizumi, Y.Fukuta, D.Inui, K.Tsuchiya, H.Houchi, T.Tamaki, K.Minakuchi Dopamine clearance during dopamine infusion in infants and children after cardiac surgery. Cardiovasc. Pharmacol. 34, S85-89, 1999.

 

21) M.Yoshizumi, D.Inui, K.Kirima, K.Tsuchiya, H.Houchi, M.Azuma, H.Yasuoka, ,H.Kido, T.Tamaki Comparison of the effects of endothelin-1, -2 and -3 (1-31) on changes in [Ca2+]i in human coronary artery smooth muscle cells. Jpn. J. Pharmacol. 81, 298-304, 1999.

 

20) K.Mori, Y.Hayabuchi, Y.Kuroda, Y.Nakaya, K.Tsuchiya, H.Moritoki Age-related endothelium-dependent vascular relaxation in rat thoracic aorta in response to colforsin. Pediatr. Int. 41, 673-81, 1999.

 

19) H.Houchi, M.Yoshizumi, K.Tsuchiya, M.Hirose, T.Kitagawa, T.Kujime, E.Shimizu, Y.Niwa, K.Minakuchi & T.Tamaki Endothelin-1 stimulates sodium-dependent calcium efflux from bovine adrenal chromaffin cells in culture. Br. J. Pharmacol. 125, 55-60, 1998.

 

18) M.Yoshizumi, S.Kim, S.Kagami, A.Hamaguchi, K.Tsuchiya, H.Houchi, H.Iwao, H.Kido, T.Tamaki. Effect of endothelin-1(1-31)on extracellular signal-regulated kinase and proliferation of human coronary artery smooth muscle cells. Br. J. Pharmacol. 124, 1019-1027, 1998.

 

17) M.Yoshizumi, T.Kitagawa, Y.Ozawa, K.Tano, K.Tsuchiya, H.Houchi, K.Minakuchi and T.Tamaki. Changes in plasma free and sulfoconjugated catecholamines during the perioperative period of cardiac surgery:Effect of continuous infusion of dopamine. Bio. Pharmaceut. Bull. 21, 787-791, 1998.

 

16) A.Tokumura, M.Okuno, K.Fukuzawa, H.Houchi, K.Tsuchiya, M.Oka Positive and negative controls by protein kinases of sodium-dependent Ca2+ efflux from cultured bovine adrenal chromaffin cells stimulated by lysophosphatidic acid. Biochim. Biophys. Acta. 1389, 67-75, 1998.

 

15) M. Yoshizumi, Daisuke Inui, Naoko Okishima, Hitoshi Houchi, Koichiro Tsuchiya, Hideki Wakabayashi, Hiroshi Kido, Toshiaki Tamaki. Endothelin-1(1-31), a novel vasoactive peptide, increases [Ca2+]i in human coronary artery smooth muscle cells. Eur. J. Pharamacol. 348, 305-309, 1998.

 

14) M. Yoshizumi, H. Houchi, K. Tsuchiya, K. Minakuchi, K. Horike, T. Kitagawa, I. Katoh, T. Tamaki. Atrial natriuretic peptide stimulates Na+-dependent Ca2+ efflux from freshly isolated adult rat cardiomyocytes. FEBS Letters 419, 255-258, 1997.

 

13) M. Yoshizumi, H. Houchi, Y. Ishimura, M. Hirose, T. Kitagawa, K. Tsuchiya, K. Minakuchi, T. Tamaki Effect of evodiamine on catecholamine secretion from bovine adrenal medulla. J. Med. Invest. 44, 73-78, 1997.

 

12) Y.Nameda, H.Miyoshi, K.Tsuchiya, Y.Nakaya, S.Arase Endotoxin-induced L-arginine pathway produces nitric oxide and modulates the Ca2+-activated K+ channel in cultured human dermal papilla cells. J Invest Dermatol. 106, 342-345, 1996.

 

11) K.Mori, S.Takeuchi, H.Moritoki, K.Tsuchiya, Y.Nakaya, S.Matsuoka, Y.Kuroda Endothelium-dependent relaxation of rat thoracic aorta by amrinone-induced nitric oxide release. Eur. Heart J. 17, 308-316, 1996.

 

10) K.Nakauchi, T.Ikata, S.Katoh, Y.Hamada, K.Tsuchiya, K.Fukuzawa Effects of lecithinized superoxide dismutase on rat spinal cord injury. J. Neurotrauma. 13, 573-582, 1996.

 

9) K.Tsuchiya, M.Takasugi, K.Minakuchi, K.Fukuzawa Sensitive quantitation of nitric oxide by EPR spectroscopy. Free Radic. Biol. Med. 21, 733-737, 1996.

 

8) Y.Hamada, T.Ikata, S.Katoh, K.Tsuchiya, M.Niwa, Y.Tsutsumishita, K.Fukuzawa Roles of nitric oxide in compression injury of rat spinal cord. Free Radic. Biol. Med. 20, 1-9, 1996.

 

7) H.Sakurai, M.Nakai, T.Miki, K.Tsuchiya, J.Takada, R.Matsuchita DNA cleavage by hydroxyl radicals generated in a vanadyl ion-hydrogen peroxide system. Biochem. Biophys. Res. Commun. 189, 1090-1095, 1992.

 

6) H.Sakurai and K.Tsuchiya A Biomimetic model for vanadium-containing bromoperoxidase. FEBS Letters 260, 109-112, 1990.

 

5) H.Sakurai, K.Tsuchiya, M.Nukatsuka, M.Sofue, J.Kawada Insulin-like effect of vanadyl ion on streptozotocin-induced diabetic rats. J. Endocrinol. 126, 451-459, 1990.

 

4) S.Kitagawa, F.Kametani, K.Tsuchiya, H.Sakurai ESR analysis with long-chain alkyl spin labels in bovine blood platelets. Relationship between the increase in membrane fluidity by alcohols and phenolic compounds and their inhibitory effects on aggregation. Biochim. Biophys. Acta. 1027, 123-129, 1990.

 

3) H. Sakurai and K.Tsuchiya Dating of human blood by electron spin resonance spectroscopy. Natur Wissenschaften 76, 24-25, 1989.

 

2) H.Sakurai, K.Tsuchiya, K.Migita An active-site model of nitrile hydratase: Axially coordinate non-heme iron complexes in the low-spin ferric state. Inorganic Chemistry 27, 3877-3879, 1988.

 

1) H. Sakurai and K.Tsuchiya Correlation of levels of Pt and Se in rats treated simultaneously with cisplatin and sodium selenite. Natur Wissenschaften 75, 405-406, 1988.