Professor MORINO Hiroyuki

  In our laboratory, we mainly focus on the identification of causative genes and pathogenesis of hereditary diseases, and the study of RNAs derived from ultraconserved regions and RNA methylation modifications for malignant tumors, such as colorectal cancer. Regarding hereditary diseases, we have successfully identified several causative genes for neurodegenerative disorders, including Parkinson’s disease and dystonia, and are conducting functional analysis of these genes. In addition to approaches from biochemistry and cell biology, we leverage open science and utilize bioinformatics to analyze the validity of diseasecausing genetic changes from publicly available multi-omics data. In the field of tumor research, we are identifying novel functional RNAs that regulate pathogenesis and advancing research toward the establishment of biomarkers and new therapeutic strategies.