Professor WAKINO Shu

  Phosphoenolpyruvate carboxykinase（PEPCK）is part of the gluconeogenesis pathway, which maintains fasting glucose levels and affects renal physiology. PEPCK consists of two isoforms PEPCK1 and PEPCK2-that the Pck1 and Pck2 genes encode. We used genetically modified mice to investigate whether renal gluconeogenesis and Pck1activity are renoprotective in DN. We elucidated that PCK1preserves mitoribosomal function and may play a novel protective role in DN（Hasegawa K, Tamaki M, Wakino S, et, al. JASN 2023）．