Nano Materials Laboratory
(Miyoshi's Lab.)
Project
Stuff
Introduction
Collaborates
Grants
- High Density Packed Stable Fluorescent Probes encapsulated in Silica NPs
- Enhanced Radiochromic Materials to detect low dose <0.01Gy
- Network Structure of Silica NPs and its Radiation Effects
- Preparation of Functional Silica Nanocapsules for DDS
- X-ray wavelength shifter for X-ray phosphor
- Organic-Inorganic nano composit
- Preparation and photoelectric property of Titania Nanocapsule
- Fixation of Radioisotope in Silica NP
- Preparation of Scintillation Molecules encapsulated in Silica NPs
Stuff 2010
(Josanjima Campus): Room project14&15
Dr. Hirokazu Miyoshi, Radioisotope Research Center
Co worker
Associate Prof. Dr. Liu Yiyao, Associate Professor at Dept. of Biophysics, Svchool of Life Science and Technology, Univ. of Electronic Science and Technology of China (Temporary)
Graduate Students
Shigehiro Kaitani, Koichi Hiura, and Kensho Sakamoto, MS from Institute of Technology and Science, Chemical Science and Techinology
We have started the reserch on Silica Nano Bubble from 1999 under Prof. Dan Meisel at Radiation Laboratory, University of Notre Dame ,and University of Chicago under Prof. James Norris, Jr.. At that time, our reseraches were on silica nano bubble and silica nanoparticle. Also, we were using Spin Label method to investigate the surface of the nano sized Au particle with Prof. Agnes Ostafin at University of Notre Dame. We have investigated the following things;
Encapsulation of FITC into Silica Nanobubble
Behavior of EPR Signal on Au nano particle
Encapsulation of Methylviologen into Silica Nanobubble
Encapsulation of ADH into Silica Nanobubble and its activity
Behavior of H2 produced in irradiated silica nanoparticle aqueous suspension
Those approches lead us the knowledges and procedure about the silica nanobubble. Still I have some questions, i.e. nanosize silica is complete insulator?, why minus ion goes into silica nanobubble?, why nanosize silica eliminates H2?, etc. So, silica nanoparticles are very interesting and we will try to use in several area with different approches here. The one is Molecular Imagig and another one is Radiation Safety Control. We will develop the probes for the living cell, on Optical Imaging and Nuclear Imaging, that is,
To make high intensity Fluorescent Probe encapsulated in Silica Nanoparticles
To make PET species encapsulated in silica nanoparticles.
The high density pack of fluorescent probe in the silica nanoparticles is effective for the optical imaging. In the case of quantum dots, the size can not change to pack highly. Because the emission wavelength and its color changes with its size! In human body radioisotope is very useful, because radiation emitted even from the depth site. Then, advance radiation safety and develop safe handling of radioisotopes are quite necessary for us, therefore,
To scavenge RI efficiently from its RI waste solution
To fix radioisotope in the silica nanopartilce
To detect low exposure dose by color change
will be done in our Laboratory. Development of radiochromic materials will lead to detect such low dose. Those materials is wated for the Radiation Workers in the controlled area and for IVR in medical field. Also the decrease of RI waste should be done. Therefore the development of the procedure must hurry! If Radioisotope are encapsulated in the silica nanoparticle, its handling and collect will become easy. That leads us Radiation Safety!
Now, we are trying the above things in our Laboratory!!
8. Preparation, characterization and release of methyl viologen from a novel nanoparticles delivery system with double shells of silica and PLGA., H. yang, H. Miyoshi, C. Lou, Z. Ren, and L. Yiyao, Chinese Science Bulletin, 55, 263-267, 2010.
7. Control of emission peaks of X-ray phosphor using dye-silica nanoparticles., H, Miyoshi, H. Imura, and M. Nakamura, J. Lumin., 130, 404-410, 2010.
6. Behavior of fluorescent molecules bound to the interior of silica nanoparticles in various solvents., H. Miyoshi, Y. Matsuo, L. Yiyao, T. Sakata, and H. Mori, J. Colloid Interface Sci., 331, 507-513, 2009.
5. Poly(D, lactide-co-glycolide) Nanoparticles Encapsulated Fluorescent Isothiocyanate and Paclitaxol: Preparation, Release Kinetics and Anticancer Effect., Y. hong, L. Kai, L. Yiyao, L. Zhonghua and H. Miyoshi, J. Nanosci. Nanotechnol. 9. 282-287, 2009.
4. Preparation and Characterization of Novel Drug Delivery System of Light-Sensitive Silica Nanocapsules with Thin Shells.,L. Yiyao and H. Miyoshi, Journal of Biomedical Nanotechnology, 4, 25-32, 2008.
3. Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells: Preparation and fluorescein isothiocyanate (FITC) release kinetics. International Journal of Pharmaceutics. Liu Y., Miyoshi H. and Nakamura M., Colloids Surf B: Biointerfaces. ,58, 180-187, 2007.
2. Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis by targeted functional nanoparticles. Liu Y., Miyoshi H. and Nakamura M. , Int. J.of Cancer,120, 2527-2537(2007) .
1. Encapsulated ultrasound microbubbles: Therapeutic application in drug/gene delivery, Yiyao Liu, Hirokazu Miyoshi, Michihiro Nakamura, Journal of controlled release, 114, 89-99(2006).
University of Tokushima
2000~
Prof. Takahama, Institute for Genome Research
Prof. Satake, Center for Cooperative Research
Prof. Kanezaki, Institute of Technology and Science, Chemical Science and Techinology
Prof. Kourai, Institute of Technology and Science, Chemical Science and Techinology
Dr. Shono, IHBS
Assistant professor Nakamura, IHBS, ~2006
2006~
Prof. Nakayama, Faculty of Integrated Arts and Sciences
University of Nagoya
Prof. Baba, Department of Applied Chemistry
University of Kochi
Prof. Yoshida, Materials Science
Osaka University
Prof. Mori, Research Center for Ultra-High Voltage Electron Microscopy
Prof. Kuwabata, Engineering
2006~
Resarch Associate. Ikeda, The Institute of Sciencetific and Industrial Research
Tohoku University 2003-2004
Prof. Iwata, CYRIC
Shikoku TLO
Miss Shimadzu
2003~2004
Japan Atomic Energy Institute
2009
1. Kaken Hoga(keizoku)
2. Ikusei research by Chizai
3. Awagin Zaidan (co worker)
2008
1. NEDO 2008 Innovation
2. Kaken Hoga(keizoku)
2007
1. NEDO 2005 Nakamura project
2. Kaken Hoga
2006
1. NEDO 2005 Nakamura project
2. Shikoku Electric Power Co., INC
2005
1. Shikoku Electric Power Co., INC
2. NEDO 2005, Nakamura project
2004
1. Shikoku Electric Power Co., INC
2003
1. Shikoku Electric Power Co., INC
2. Japan Atomic Energy Institute
2002
1. Shikoku Electric Power Co., INC
March 3rd, 2010
