研究業績

2017年

Ohoka N, Okuhira K, Ito M, Nagai K, Shibata N, Hattori T, Ujikawa O, Shimokawa K, Sano O, Koyama R, Fujita H, Teratani M, Matsumoto H, Imaeda Y, Nara H, Cho N, Naito M.
In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic IAP-dependent Protein Erasers (SNIPERs).
J Biol Chem. 292, 4556-4570 (2017)

 

Okuhira K, Shoda T, Omura R, Ohoka N, Hattori T, Shibata N, Demizu Y, Sugihara R, Ichino A, Kawahara N, Itoh Y, Ishikawa M, Hashimoto Y, Kurihara M, Itoh S, Saito H, Naito M.
Targeted degradation of proteins localized in subcellular compartments by hybrid small molecules.
Mol Pharmacol. 91, 159-166 (2017)

 

2016年

Kameyama H, Nakajima H, Nishitsuji K, Mikawa S, Uchimura K, Kobayashi N, Okuhira K, Saito H, Sakashita N.
Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes.
Sci Rep. 6, 30391 (2016)

 

Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M.
Development of a peptide-based inducer of nuclear receptors degradation.
Bioorg Med Chem Lett. 26, 2655-8 (2016)

 

Kariyazono H, Nadai R, Miyajima R, Takechi-Haraya Y, Baba T, Shigenaga A, Okuhira K, Otaka A, Saito H.
Formation of stable nanodiscs by bihelical apolipoprotein A-I mimetic peptide.
J. Pept. Sci. 22, 116-22 (2016)

 

Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Kurihara M, Naito M.
Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.
Methods Mol Biol. 1366, 549-60 (2016)

 

2015年

Kuwabara K, Nishitsuji K, Uchimura K, Mizuguchi M, Nakajima H, Kobayashi N, Saito H, Sakashita N.
Cellular Interaction and Cytotoxicity of the Iowa Mutation of Apolipoprotein A-I (ApoA-I Iowa) Amyloid Mediated by Sulfate Moieties of Heparan Sulfate.
J. Biol. Chem. 290, 24210-21 (2015)

 

Gorbenko G, Trusova V, Girych M., Adachi E, Mizuguchi C, Saito H.
Interactions of Lipid Membranes with Fibrillar Protein Aggregates. In Lipids in Protein Misfolding (Gursky O. ed., Springer)
Adv. Exp. Med. Biol. 855, pp.135-55 (2015)

 

Mizuguchi C, Ogata F, Mikawa S, Tsuji K, Baba T, Shigenaga A, Shimanouchi T, Okuhira K, Otaka A, Saito H.
Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes.
J. Biol. Chem. 290, 20947-59 (2015)

 

Demizu Y, Misawa T, Nagakubo T, Kanda Y, Okuhira K, Sekino Y, Naito M, Kurihara M.
Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription.
Bioorg Med Chem. 23, 4132-8 (2015)

 

Shoda T, Kato M, Harada R, Fujisato T, Okuhira K, Demizu Y, Inoue H, Naito M, Kurihara M.
Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators.
Bioorg Med Chem. 23, 3091-6 (2015)

 

Gorbenko G, Trusova V, Girych M, Adachi E, Mizuguchi C, Akaji K, Saito H.
FRET evidence for untwisting of amyloid fibrils on the surface of model membranes.
Soft Matter 11, 6223-6234 (2015)

 

Takechi-Haraya Y, Tanaka K, Tsuji K, Asami Y, Izawa H, Shigenaga A, Otaka A, Saito H, Kawakami K.
Molecular complex composed of β-cyclodextrin-grafted chitosan and pH-sensitive amphipathic peptide for enhancing cellular cholesterol efflux under acidic pH.
Bioconjugate Chem. 26, 572-581 (2015)

 

Trusova V, Gorbenko G, Girych M, Adachi E, Mizuguchi C, Sood R, Kinnunen P, Saito H.
Membrane Effects of N-Terminal Fragment of Apolipoprotein A-I: A Fluorescent Probe Study.
J. Fluoresc. 25, 253-261 (2015)

 

Handa D, Kimura H, Oka T, Takechi Y, Okuhira K, Phillips M C, Saito H.
Kinetic and Thermodynamic Analyses for Spontaneous Exchange between High Density Lipoprotein-bound and Lipid-free Apolipoprotein A-I.
Biochemistry 54, 1123-1131 (2015)

 

Ohmoto T, Nishitsuji K, Yoshitani N, Mizuguchi M, Yanagisawa Y, Saito H, Sakashita N.
A specific acyl-CoA:cholesterol acyltransferase inhibitor, K604, suppresses proliferation of U251-MG glioblastoma cells.
Mol. Med. Rep. 12, 6037-42 (2015)

 

2014年

奥平 桂一郎
トランスポーターABCA1と相互作用タンパク質によるHDL産生制御機構
膜 39, 74-79 (2014)

 

Mizuguchi C, Hata M, Dhanasekaran P, Nickel M, Okuhira K, Phillips MC, Lund-Katz S, Saito H.
Fluorescence Study of Domain Structure and Lipid Interaction of Human Apolipoproteins E3 and E4.
Biochim. Biophys. Acta - Mol. Cell Biol. Lipids 1841, 1716-1724 (2014)

 

Ohoka N, Nagai K, Hattori T, Okuhira K, Shibata N, Cho N, Naito M.
Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway.
Cell Death Dis. 5, e1513 (2014)

 

Nagakubo T, Demizu Y, Kanda Y, Misawa T, Shoda T, Okuhira K, Sekino Y, Naito M, Kurihara M.
Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.
Bioconjug. Chem. 25, 1921-4 (2014)

 

Cui H, Wu W, Okuhira K, Miyazawa K, Hattori T, Sai K, Naito M, Suzuki K, Nishimura T, Sakamoto Y, Ogata A, Maeno T, Inomata A, Nakae D, Hirose A, Nishimaki-Mogami T.
High-temperature calcined fullerene nanowhiskers as well as long needle-like multi-wall carbon nanotubes have abilities to induce NLRP3-mediated IL-1β secretion.
Biochem. Biophys. Res. Commun. 452, 593-9 (2014)

 

Shoda T*, Okuhira K* (*equal contribution), Kato M, Demizu Y, Inoue H, Naito M, Kurihara M.
Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.
Bioorg. Med. Chem. Lett. 24, 87-89 (2014)

 

Omura R, Nagao K, Kobayashi N, Ueda K, Saito H.
Direct Detection of ABCA1-dependent HDL Formation Based on Lipidation-induced Hydrophobicity Change in ApoA-I.
J. Lipid Res. 55, 2423-2431 (2014)

 

Nguyen D, Dhanasekaran P, Nickel M, Mizuguchi C, Watanabe M, Saito H, Phillips MC, Lund-Katz S.
Influence of Domain Stability on the Properties of Human Apolipoprotein E3 and E4 and Mouse Apolipoprotein E.
Biochemistry 53, 4025-4033 (2014)

 

Girych M, Gorbenko G, Trusova V, Adachi E, Mizuguchi C, Nagao K, Kawashima H, Akaji K, Lund-Katz S, Phillips MC, Saito H.
Interaction of Thioflavin T with Amyloid Fibrils of Apolipoprotein A-IN-terminal Fragment: Resonance Energy Transfer Study.
J. Struct. Biol. 185, 116-124 (2014)

 

Adachi E, Kosaka A, Tsuji K, Mizuguchi C, Kawashima H, Shigenaga A, Nagao K, Akaji K, Otaka A, Saito H.
The Extreme N-terminal Region of Human Apolipoprotein A-I Has a Strong Propensity to Form Amyloid Fibrils.
FEBS Lett. 588, 389-394 (2014)

 

2013年

Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Nishimaki-Mogami T, Okuda H, Kurihara M, Naito M.
Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.
Cancer Sci. 104, 1492-1498 (2013)

 

Adachi E, Nakajima H, Mizuguchi C, Dhanasekaran P, Kawashima H, Nagao K, Akaji K, Lund-Katz S, Phillips MC, Saito H.
Dual Role of an N-terminal Amyloidogenic Mutation in Apolipoprotein A-I : Destabilization of Helix Bundle and Enhancement of Fibril Formation.
J. Biol. Chem. 288, 2848-2856 (2013)

 

Nguyen D, Nickel M, Mizuguchi C, Saito H, Lund-Katz S, Phillips MC
Interaction of Apolipoprotein A-I with High Density Lipoprotein Particles.
Biochemistry 52, 1963-1972 (2013)

 

2012年

奥平 桂一郎
HDL 産生におけるABCトランスポーターA1の活性制御機構
生化学 84, 285-90 (2012)

 

Itoh Y, Ishikawa M, Kitaguchi R, Okuhira K, Naito M, Hashimoto Y.
Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist.
Bioorg. Med. Chem. Lett. 22, 4453-4457 (2012)

 

Ohoka N, Okuhira K, Cui H, Wu W, Sato R, Naito M, Nishimaki-Mogami T.
HNF4α increases liver-specific human ATP-binding cassette transporter A1 expression and cholesterol efflux to apolipoprotein A-I in response to cholesterol depletion.
Arterioscler. Thromb. Vasc. Biol. 32, 1005-1014 (2012)

 

Demizu Y, Okuhira K, Motoi H, Ohno A, Shoda T, Fukuhara K, Okuda H, Naito M, Kurihara M.
Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy.
Bioorg. Med. Chem. Lett. 22, 1793-1796 (2012)

 

Mizuguchi C, Hata M, Dhanasekaran P, Nickel M, Phillips MC, Land-Katz S, Saito H.
Fluorescence analysis of the lipid binding-induced conformational changes of apolipoprotein E4.
Biochemistry 51, 5580-5588 (2012)

 

Takechi Y, Mizuguchi C, Tanaka M, Kawakami T, Aimoto S, Okamura E, Saito H.
Physicochemical Mechanism for the Lipid Membrane Binding of Polyarginine: the Favorable Enthalpy Change with Structural Transition from Random Coil to Alpha Helix.
Chem. Lett. 41, 1374-1376 (2012)