原著論文・総説

原著論文・総説

73: Kitakaze K, Tasaki C, Tajima Y, Hirokawa T, Tsuji D, Sakuraba H, Itoh K.

Combined replacement effects of human modified beta-hexosaminidase B and GM2 activator protein on GM2 gangliosidoses fibroblasts.

Biochem Biophys Rep in press

 

72: Rahman MM, Hirokawa T, Tsuji D, Tsukimoto J, Hitaoka S, Chuman H, Itoh K.

Novel pH-dependent regulation of human cytosolic sialidase 2 (NEU2) activities by siastatin B and structural prediction of NEU2/siastatin B complex.

Biochem Biophys Rep in press

 

71: Ogawa Y, Sano T, Irisa M, Kodama T, Saito T, Furusawa E, Kaizu K, Yanagi Y, Tsukimura T, Togawa T, Yamanaka S, Itoh K, Sakuraba H, Oishi K.

FcRγ-dependent immune activation initiates astrogliosis during the asymptomatic phase of Sandhoff disease model mice.

Sci Rep 7 40518 (2017)

 

70: Kitakaze K, Mizutani Y, Sugiyama E, Tasaki C, Tsuji D, Maita N, Hirokawa T, Asanuma D, Kamiya M, Sato K, Setou M, Urano Y, Togawa T, Otaka A, Sakuraba H, Itoh K.

Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model.

J Clin Invest 126 1691-703 (2016)

 

69: Kawashita E, Tsuji D, Kanno Y, Tsuchida K, Itoh K.

Potentiation of uridine diphosphate-induced production of macrophage inflammatory protein-1 alpha in microglia derived from Sandhoff disease model mice.

JIMD Rep28 85-93 (2016)

 

68: Nakamura T, Sato K, Naruse N, Kitakaze K, Inokuma T, Hirokawa T, Shigenaga A, Itoh K, Otaka A.

Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues that Allows Facile Access to a Protein Library.

Chembiochem 17 1986-92 (2016)

 

67: Morisaki T, Denda M, Yamamoto J, Tsuji D, Inokuma T, Itoh K, Shigenaga A, Otaka A.

An N-sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins.

Chem Commun 52 6911-3 (2016)

 

66: Itoh K, Kobayashi I, Nishioka S, Sezutsu H, Machii H, Tamura T.

Recent progress in development of transgenic silkworms overexpressing recombinant human proteins with therapeutic potential in silk glands.

Drug Discov Ther 10 34-9 (2016)

 

65: Hanson DJ, Nakamura S, Amachi R, Hiasa M, Oda A, Tsuji D, Itoh K, Harada T, Horikawa K, Teramachi J, Miki H, Matsumoto T, Abe M.

Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.

Oncotarget 6 33568-86 (2015)
 

64: Tsuda Y, Shigenaga A, Tsuji K, Denda M, Sato K, Kitakaze K, Nakamura T, Inokuma T, Itoh K, Otaka A.

Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System.

ChemistryOpen 4 448-52 (2015)

 

63: Sato K, Kitakaze K, Nakamura T, Naruse N, Aihara K, Shigenaga A, Inokuma T, Tsuji D, Itoh K, Otaka A.

Total chemical synthesis of monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate.

Chem Comm 51 9946-8 (2015)

 

62: Hiasa M, Teramachi J, Oda A, Amachi R, Harada T, Nakamura S, Miki H, Fujii S, Kagawa K, Watanabe K, Endo I, Kuroda Y, Yoneda T, Tsuji D, Nakao M, Tanaka E, Hamada K, Sano S, Itoh K, Matsumoto T, Abe M.
Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma.
Leukemia 29 207-17. (2015)

 

61: Gallat FX, Matsugaki N, Coussens NP, Yagi KJ, Boudes M, Higashi T, Tsuji D, Tatano Y, Suzuki M, Mizohata E, Tono K, Joti Y, Kameshima T, Park J, Song C, Hatsui T, Yabashi M, Nango E, Itoh K, Coulibaly F, Tobe S, Ramaswamy S, Stay B, Iwata S, Chavas LM.
In vivo crystallography at X-ray free-electron lasers: the next generation of structural biology?
Philos Trans R Soc Lond B Biol Sci 369 20130497. (2014)


60: Fukuishi N, Murakami S, Ohno A, Yamanaka N, Matsui N, Fukutsuji K, Yamada S, Itoh K, Akagi M.
Does β-Hexosaminidase Function Only as a Degranulation Indicator in Mast Cells? The Primary Role of β-Hexosaminidase in Mast Cell Granules.
J Immunol 193 1886-94. (2014)

 

59: Ikuo M, Nagano G, Saito Y, Mao H, Sekimizu K, Kaito C.
Inhibition of exotoxin production by mobile genetic element SCCmec-encoded psm-mec RNA is conserved in staphylococcal species.
PLoS One 9 e100260. (2014)

 

58: Ferrajoli A, Shanafelt TD, Ivan C, Shimizu M, Rabe KG, Nouraee N, Ikuo M, Ghosh AK, Lerner S, Rassenti LZ, Xiao L, Hu J, Reuben JM, Calin S, You MJ, Manning JT, Wierda WG, Estrov Z, O'Brien S, Kipps TJ, Keating MJ, Kay NE, Calin GA.
Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia.
Blood 122 1891-9. (2013)

 

57: Kaito C, Saito Y, Ikuo M, Omae Y, Mao H, Nagano G, Fujiyuki T, Numata S, Han X, Obata K, Hasegawa S, Yamaguchi H, Inokuchi K, Ito T, Hiramatsu K, Sekimizu K.
Mobile genetic element SCCmec-encoded psm-mec RNA suppresses translation of agrA and attenuates MRSA virulence.
PLoS Pathog 9 e1003269. (2013)

 

56: Tsuji D, Itoh K.
Molecular Therapy for Lysosomal Storage Diseases.
InTech in Gene Therapy - Tools and Potential Applications Chapter 24. (2013)

 

55: Nakayama Y, Nakamura N, Tsuji D, ItohK, Kurosaka A.
Genetic Diseases Associated with Protein Glycosylation Disorders in Mammals.
InTech in Genetic Disorders Chapter 10. (2013)

 

54: Kikuchi Y, Yamazaki N, Tarashima N, Furukawa K, Takiguchi Y, Itoh K, Minakawa N.
Gene suppression via U1 small nuclear RNA interference (U1i) machinery using oligonucleotides containing 2'-modified-4'-thionucleosides.
Bioorg Med Chem 21 5292-6. (2013)

 

53: HaradaT, Ozaki S, Oda A, Tsuji D, Ikegame A, Iwasa M, Udaka K, Fujii S, Nakamura S, Miki H, Kagawa K, Kuroda Y, Kawai S, Itoh K, Yamada-Okabe H, Matsumoto T, Abe M.
Combination with a defucosylated anti-HM1.24 monoclonal antibody plus lenalidomide induces marked ADCC against myeloma cells and their progenitors.
PLoS ONE 8 e83905. (2013)

 

52: Sato K, Shigenaga A, Kitakaze K, Sakamoto K, Tsuji D, Itoh K, Otaka A.
Chemical Synthesis of Biologically Active Monoglycosylated GM2-activator Protein Analog Using N-Sulfanylethylanilide Peptide.
Angew Chem Int Ed 52 7855-9. (2013)

 

51: Rahman MM, Kitao S, Tsuji D, Suzuki K, Matsuoka K, Matsuzawa F, Aikawa S, Itoh K.
Inhibitory effects and specificity of synthetic sialyldendrimers toward recombinant human cytosolic sialidase 2 (NEU2).
Glycobiology 23 495-504. (2013)

 

50: Tsuji D.
Molecular pathogenesis and therapeutic approach of GM2 gangliosidosis.
Yakugaku Zasshi 133 269-74. (2013)

 

49: Ikegame A, Ozaki S, Tsuji D, Harada T, Fujii S, Nakamura S, Miki H, Nakano A, Kagawa K, Takeuchi K, Abe M, Watanabe K, Hiasa M, Kimura N, Kikuchi Y, Sakamoto A, Habu K, Endo M, Itoh K, Yamada-Okabe H, Matsumoto T.
Small molecule antibody targeting HLA class I inhibits myeloma cancer stem cells by repressing pluripotency-associated transcription factors.
Leukemia 26 2124-34. (2012)

 

48: Tsuji D, Akeboshi H, Matsuoka K, Yasuoka H, Miyasaki E, Kasahara Y, Kawashima I, Chiba Y, Jigami Y, Taki T, Sakuraba H, Itoh K.
Highly phosphomannosylated enzyme replacement therapy for GM2 gangliosidosis.
Ann Neurol 69 691-701. (2011)

 

47: Matsuoka K, Tamura T, Tsuji D, Dohzono Y, Kitakaze K, Ohno K, Saito S, Sakuraba H, Itoh K.
Therapeutic potential of intracerebroventricular replacement of modified human β-hexosaminidase B for GM2 gangliosidosis.
Mol Ther 19 1017-24. (2011)

 

46: Kodama T, Togawa T, Tsukimura T, Kawashima I, Matsuoka K, Kitakaze K, Tsuji D, Itoh K, Ishida Y, Suzuki M, Suzuki T, Sakuraba H.
Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.
PLoS One. 6 e29074. (2011)

 

45: Nakano A, Tsuji D, Miki H, Cui Q, El Sayed SM, Ikegame A, Oda A, Amou H, Nakamura S, Harada T, Fujii S, Kagawa K, Takeuchi K, Sakai A, Ozaki S, Okano K, Nakamura T, Itoh K, Matsumoto T, Abe M.
Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells.
PLoS One 6 e27222. (2011)

 

44: Purwanti N, Tsuji D, Azlina A, Karabasil MR, Javkhlan P, Hasegawa T, Yao C, Akamatsu T, Itoh K, Hosoi K.
Induction of Sca-1 in the duct cells of the mouse submandibular gland by obstruction of the main excretory duct.
J Oral Pathol Med 40 651-8. (2011)

 

43: Hitaoka S, Matoba H, Harada M, Yoshida T, Tsuji D, Hirokawa T, Itoh K, Chuman H.
Correlation analyses on binding affinity of sialic acid analogues and anti-influenza drugs with human neuraminidase using ab initio MO calculations on their complex structures--LERE-QSAR analysis (IV).
J Chem Inf Model 51 2706-16. (2011)

 

42: Matsuoka K, Tsuji D, Taki T, Itoh K.
Thymic involution and corticosterone level in Sandhoff disease model mice: new aspects the pathogenesis of GM2 gangliosidosis.
J Inherit Metab Dis 34 1061-8. (2011)

 

41: Kawabata R, Oie S, Takahashi M, Kanayama H, Oka T, Itoh K.
Up-regulation of insulin-like growth factor-binding protein 3 by 5-fluorouracil (5-FU) leads to the potent anti-proliferative effect of androgen deprivation therapy combined with 5-FU in human prostate cancer cell lines.
Int J Oncol 38 1489-500. (2011)

 

40: Kawashita E, Tsuji D, Toyoshima M, Kanno Y, Matsuno H, Itoh K.
Prostaglandin E2 reverses aberrant production of an inflammatory chemokine by microglia from Sandhoff disease model mice through the cAMP-PKA pathway.
PLoS One 6 e16269. (2011)

 

39: Kawabata R, Oie S, Oka T, Takahashi M, Kanayama H, Itoh K.
Hydroxyflutamide enhances cellular sensitivity to 5-fluorouracil by suppressing thymidylate synthase expression in bicalutamide-resistant human prostate cancer cells.
Int J Oncol 38 665-76. (2011)

 

38: Ito T, Kitamura H, Uwatoko C, Azumano M, Itoh K, Kuwahara J.
Interaction of Sp1 zinc finger with transport factor in the nuclear localization of transcription factor Sp1.
Biochem Biophys Res Commun 403 161-6. (2010)

 

37: Matsuoka K, Tsuji D, Aikawa S, Matsuzawa F, Sakuraba H, Itoh K.
Introduction of an N-glycan sequon into HEXA enhances human beta-hexosaminidase cellular uptake in a model of Sandhoff disease.
Mol Ther 18 1519-26. (2010)

 

36: Miyoshi K, Tsuji D, Kudoh K, Satomura K, Muto T, Itoh K, Noma T.
Generation of human induced pluripotent stem cells from oral mucosa.
J Biosci Bioeng 110 345-50. (2010)

 

35: Kawashima N, Nakayama K, Itoh K, Itoh T, Ishikawa M, Biju V.
Reversible dimerization of EGFR revealed by single-molecule fluorescence imaging using quantum dots.
Chemistry 16 1186-92. (2010)

 

34: Tajima Y, Kawashima I, Tsukimura T, Sugawara K, Kuroda M, Suzuki T, Togawa T, Chiba Y, Jigami Y, Ohno K, Fukushige T, Kanekura T, Itoh K, Ohashi T, Sakuraba H.
Use of a modified alpha-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry disease.
Am J Hum Genet 85 569-80. (2009)

 

33: Fukui Y, Kato M, Inoue Y, Matsubara A, Itoh K.
A metabonomic approach identifies human urinary phenylacetylglutamine as a novel marker of interstitial cystitis.
J Chromatogr B Analyt Technol Biomed Life Sci 877 3806-12. (2009)

 

32: Kawashima N, Tsuji D, Okuda T, Itoh K, Nakayama K.
Mechanism of abnormal growth in astrocytes derived from a mouse model of GM2 gangliosidosis.
J Neurochem 111 1031-41. (2009)

 

31: Yoshida T, Kadota Y, Hitaoka S, Kori E, Horikawa Y, Taguchi M, Tsuji D, Hirokawa T, Chuman H, Itoh K.
Expression and molecular dynamics studies on effect of amino acid substitutions at Arg344 in human cathepsin A on the protein local conformation.
Biochim Biophys Acta 1794 1693-9. (2009)

 

30: Akeboshi H, Kasahara Y, Tsuji D, Itoh K, Sakuraba H, Chiba Y, Jigami Y.
Production of human beta-hexosaminidase A with highly phosphorylated N-glycans by the overexpression of the Ogataea minuta MNN4 gene.
Glycobiology 19 1002-9. (2009)

 

29: Kawashita E, Tsuji D, Kawashima N, Nakayama K, Matsuno H, Itoh K.
Abnormal production of macrophage inflammatory protein-1alpha by microglial cell lines derived from neonatal brains of Sandhoff disease model mice.
J Neurochem 109 1215-24. (2009)

 

28: Sugawara K, Tajima Y, Kawashima I, Tsukimura T, Saito S, Ohno K, Iwamoto K, Kobayashi T, Itoh K, Sakuraba H.
Molecular interaction of imino sugars with human alpha-galactosidase: Insight into the mechanism of complex formation and pharmacological chaperone action in Fabry disease.
Mol Genet Metab 96 233-8. (2009)

 

27: Ito T, Azumano M, Uwatoko C, Itoh K, Kuwahara J.
Role of zinc finger structure in nuclear localization of transcription factor Sp1.
Biochem Biophys Res Commun 380 28-32. (2009)

 

26: Kawashima N, Yoon SJ, Itoh K, Nakayama K.
Tyrosine kinase activity of epidermal growth factor receptor is regulated by GM3 binding through carbohydrate to carbohydrate interactions.
J Biol Chem 284 6147-55. (2009)

 

25: Tatano Y, Fujinawa R, Kozutsumi Y, Takahashi T, Tsuji D, Takeuchi N, Tsuta K, Takada G, Sakuraba H, Itoh K.
Tropoelastin regulates chemokine expression in fibroblasts in Costello syndrome.
Biochem Biophys Res Commun 372 681-7. (2008)

 

24: Seyrantepe V, Hinek A, Peng J, Fedjaev M, Ernest S, Kadota Y, Canuel M, Itoh K, Morales CR, Lavoie J, Tremblay J, Pshezhetsky AV.
Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1.
Circulation 117 1973-81. (2008)

 

23: Yoshimizu M, Tajima Y, Matsuzawa F, Aikawa S, Iwamoto K, Kobayashi T, Edmunds T, Fujishima K, Tsuji D, Itoh K, Ikekita M, Kawashima I, Sugawara K, Ohyanagi N, Suzuki T, Togawa T, Ohno K, Sakuraba H.
Binding parameters and thermodynamics of the interaction of imino sugars with a recombinant human acid alpha-glucosidase (alglucosidase alfa): insight into the complex formation mechanism.
Clin Chim Acta 391 68-73. (2008)

 

22: Shigenaga A, Tsuji D, Nishioka N, Tsuda S, Itoh K, Otaka A.
Synthesis of a stimulus-responsive processing device and its application to a nucleocytoplasmic shuttle Peptide.
Chembiochem 8 1929-31 (2007)

 

21: 辻大輔、伊藤孝司
リソソーム病の分子病理と治療ターゲット
生化学 79 678-682 (2007)

 

20: Akeboshi H, Chiba Y, Kasahara Y, Takashiba M, Takaoka Y, Ohsawa M, Tajima Y, Kawashima I, Tsuji D, Itoh K, Sakuraba H, Jigami Y.
Production of Recombinant {beta}-Hexosaminidase A, a Potential Enzyme for Replacement Therapy for Tay-Sachs and Sandhoff Diseases, in the Methylotrophic Yeast Ogataea minuta.
Appl Environ Microbiol 73 4805-12 (2007)

 

19: Tsuji D, Higashine Y, Matsuoka K, Sakuraba H, Itoh K.
Therapeutic evaluation for GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibody.
Clin Chim Acta 378 38-41 (2007)

 

18: Yoshida T, Lepp Z, Kadota Y, Satoh Y, Itoh K, Chuman H.
Comparative analysis of binding energy of chymostatin with human cathepsin A and its homologous proteins by molecular orbital calculation.
J Chem Inf Model 46 2093-103 (2006)

 

17: Sakuraba H, Sawada M, Matsuzawa F, Aikawa S, Chiba Y, Jigami Y, Itoh K.
Molecular pathologies of and enzyme replacement therapies for lysosomal diseases.
CNS Neurol Disord Drug Targets 5 401-13 (2006)

 

16: Itakura T, Kuroki A, Ishibashi Y, Tsuji D, Kawashita E, Higashine Y, Sakuraba H, Yamanaka S, Itoh K.
Inefficiency in GM2 ganglioside elimination by human lysosomal beta-hexosaminidase beta-subunit gene transfer to fibroblastic cell line derived from Sandhoff disease model mice.
Biol Pharm Bull 29 1564-9 (2006)

 

15: Aikawa S, Matsuzawa F, Satoh Y, Kadota Y, Doi H, Itoh K.
Prediction of the mechanism of action of omuralide (clasto-lactacystin beta-lactone) on human cathepsin A based on a structural model of the yeast proteasome beta5/PRE2-subunit/omuralide complex.
Biochim Biophys Acta 1764 1372-80 (2006)

 

14: Tatano Y, Takahashi T, Tsuji D, Takeuchi N, Tsuta K, Takada G, Ohsawa M, Sakuraba H, Itoh K.
Significant decrease in tropoelastin gene expression in fibroblasts from a Japanese costello syndrome patient with impaired elastogenesis and enhanced proliferation.
J Biochem (Tokyo) 140 193-200 (2006)

 

13: Tatano Y, Takeuchi N, Kuwahara J, Sakuraba H, Takahashi T, Takada G, Itoh K.
Elastogenesis in cultured dermal fibroblasts from patients with lysosomal beta-galactosidase, protective protein/cathepsin A and neuraminidase-1 deficiencies.
J Med Invest 53 103-12 (2006)

 

12: 伊藤孝司、辻大輔、桜庭均
Sandhoff病モデルマウスから樹立されたオリゴデンドロサイトおよびシュワン細胞株における蓄積複合糖質の解析
生体の科学 57 224-8 (2006)

 

11: Sakuraba H, Murata-Ohsawa M, Kawashima I, Tajima Y, Kotani M, Ohshima T, Chiba Y, Takashiba M, Jigami Y, Fukushige T, Kanzaki T, Itoh K.
Comparison of the effects of agalsidase alfa and agalsidase beta on cultured human Fabry fibroblasts and Fabry mice.
J Hum Genet 51 180-8 (2006)

 

10: Oheda Y, Kotani M, Murata M, Sakuraba H, Kadota Y, Tatano Y, Kuwahara J, Itoh K.
Elimination of abnormal sialylglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement.
Glycobiology 16 271-80 (2006)

 

9: Ohsawa M, Kotani M, Tajima Y, Tsuji D, Ishibashi Y, Kuroki A, Itoh K, Watabe K, Sango K, Yamanaka S, Sakuraba H.
Establishment of immortalized Schwann cells from Sandhoff mice and corrective effect of recombinant human beta-hexosaminidase A on the accumulated GM2 ganglioside.
J Hum Genet 50 460-7 (2005)

 

8: Tsuji D, Kuroki A, Ishibashi Y, Itakura T, Itoh K.
Metabolic correction in microglia derived from Sandhoff disease model mice.
J Neurochem 94 1631-8 (2005)

 

7: Tsuji D, Kuroki A, Ishibashi Y, Itakura T, Kuwahara J, Yamanaka S, Itoh K.
Specific induction of macrophage inflammatory protein 1-alpha in glial cells of Sandhoff disease model mice associated with accumulation of N-acetylhexosaminyl glycoconjugates.
J Neurochem 92 1497-507 (2005)

 

6: Ishiwari K, Kotani M, Suzuki M, Pumbo E, Suzuki A, Kobayashi T, Ueno T, Fukushige T, Kanzaki T, Imada M, Itoh K, Akioka S, Tajima Y, Sakuraba H.
Clinical, biochemical, and cytochemical studies on a Japanese Salla disease case associated with a renal disorder.
J Hum Genet 49 656-63 (2004)

 

5: Sakuraba H, Itoh K.
Lysosomal neuraminidase (neuraminidase-1)
Nippon Rinsho 62 517-20 (2004)

 

4: Satoh Y, Kadota Y, Oheda Y, Kuwahara J, Aikawa S, Matsuzawa F, Doi H, Aoyagi T, Sakuraba H, Itoh K.
Microbial serine carboxypeptidase inhibitors--comparative analysis of actions on homologous enzymes derived from man, yeast and wheat.
J Antibiot (Tokyo) 57 316-25 (2004)

 

3: Itoh K, Satoh Y, Kadota Y, Oheda Y, Kuwahara J, Shimmoto M, Sakuraba H.
Expression of lysosomal protective protein/cathepsin A in a stably transformed human neuroblastoma cell line during bi-directional differentiation into neuronal and Schwannian cells.
Neurochem Int 44 447-57. (2004)

 

2: Itoh M, Kuwahara J, Itoh K, Fukuda Y, Kohya M, Shindo M, Shishido K.
Apoptosis-inducing activity of synthetic intermediates of halichlorine.
Bioorg Med Chem Lett 12 2069-72 (2002)

 

1: Itoh K, Naganawa Y, Matsuzawa F, Aikawa S, Doi H, Sasagasako N, Yamada T, Kira J, Kobayashi T, Pshezhetsky AV, Sakuraba H.
Novel missense mutations in the human lysosomal sialidase gene in sialidosis patients and prediction of structural alterations of mutant enzymes.
J Hum Genet 47 29-37 (2002)

最終更新日:2017年4月17日