Selected Publications from 2003


1.Kurokawa K, Akaike Y, Masuda K, Kuwano Y, Nishida K, Yamagishi N, Kajita K, Tanahashi T, Rokutan K. Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptotis in colon cancer cells, Oncogene. 2013 (in press)


2.Kajita K, Kuwano Y, Kitamura N, Satake Y, Nishida K, Kurokawa K, Akaike Y, Honda M, Masuda K, Rokutan K. Ets1 and heat shock factor 1 regulate transcription of the Transformer 2β gene in human colon cancer cells. J Gastroenterol. 2013 (in press)


3.Yamagishi N, Teshima-Kondo S, Masuda K, Nishida K, Kuwano Y, Dang DT, Dang LH, Nikawa T, Rokutan K. Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells. BMC Cancer. 2013;13:229.


4.Kurokawa K, Tanahashi T, Iima T, Yamamoto Y, Akaike Y, Nishida K, Masuda K, Kuwano Y, Murakami Y, Fukushima M, Rokutan K. Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells. J Gastroenterol. 2012;47:883-95


5.Kamezaki Y, Katsuura S, Kuwano Y, Tanahashi T, Rokutan K. Circulating cytokine signatures in healthy medical students exposed to academic examination stress. Psychophysiology. 2012;49(7):991-7.


6.Katsuura S, Kuwano Y, Yamagishi N, Kurokawa K, Kajita K, Akaike Y, Nishida K, Masuda K, Tanahashi T, Rokutan K.  MicroRNAs miR-144/144* and miR-16 in peripheral blood are potential biomarkers for naturalistic stress in healthy Japanese medical students. Neurosci Lett. 2012;516(1):79-84.


7.Kuwano Y, Kamio Y, Kawai T, Katsuura S, Inada N, Takaki A, Rokutan K. Autism-associated gene expression in peripheral leucocytes commonly observed between subjects with autism and healthy women having autistic children. PLoS One. 6(9):e24723. 2011


8.Kurokawa K, Tanahashi T, Murata A, Akaike Y, Katsuura S, Nishida K, Masuda K, Kuwano Y, Kawai T, Rokutan K. Effects of chronic academic stress on mental state and expression of glucocorticoid receptor α and β isoforms in healthy Japanese medical students. Stress. 2011;14(4):431-438.


9.Masuda K, Abdelmohsen K, Kim MM, Srikantan S, Lee EK, Tominaga K, Selimyan R, Martindale JL, Yang X, Lehrmann E, Zhang Y, Becker KG, Wang JY, Kim HH, Gorospe M. Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation. EMBO J. 2011;30:1040-1053.


10.Katsuura S, Kamezaki Y, Yamagishi N, Kuwano Y, Nishida K, Masuda K, Tanahashi T, Kawai T, Arisawa K, Rokutan K. Circulating vascular endothelial growth factor is independently and negatively associated with trait anxiety and depressive mood in healthy Japanese university students. Int J Psychophysiol. 2011;81(1):38-43.


11.Srikantan S, Abdelmohsen K, Lee EK, Tominaga K, Subaran SS, Kuwano Y, Kulshrestha R, Panchakshari R, Kim HH, Yang X, Martindale JL, Marasa BS, Kim MM, Wersto RP, Indig FE, Chowdhury D, Gorospe M. Translational control of TOP2A influences doxorubicin efficacy. Mol Cell Biol. 2011;31(18):3790-801.


12.Yamamoto Y, Tanahashi T, Katsuura S, Kurokawa K, Nishida K, Kuwano Y, Kawai T, Teshima-Kondo S, Chikahisa S, Tsuruo Y, Sei H, Rokutan K. Interleukin-18 deficiency reduces neuropeptide gene expressions in the mouse amygdala related with behavioral change. J Neuroimmunol. 2010;15;229(1-2):129-139.


13.Kurokawa K, Kuwano Y, Tominaga K, Kawai T, Katsuura S, Yamagishi N, Satake Y, Kajita K, Tanahashi T, Rokutan K. Brief naturalistic stress induces an alternative splice variant of SMG-1 lacking exon 63 in peripheral leukocytes. Neurosci Lett.2010;484(2):128-132.


14.Abdelmohsen K, Hutchison ER, Lee EK, Kuwano Y, Kim MM, Masuda K, Srikantan S, Subaran SS, Marasa BS, Mattson MP, Gorospe M. miR-375 inhibits differentiation of neurites by lowering HuD levels. Mol Cell Biol. 2010;30(17):4197-4210.


15.Katsuura S, Kamezaki Y, Tominaga K, Masuda K, Nishida K, Yamamoto Y, Takeo K,Yamagishi N, Tanahashi T, Kawai T, Rokutan K. High-throughput screening of brief naturalistic stress-responsive cytokines in university students taking examinations. Int J Psychophysiol. 2010; 77(2):135-140.


16.Lee EK, Kim HH, Kuwano Y, Abdelmohsen K, Srikantan S, Subaran SS, Gleichmann M, Mughal MR, Martindale JL, Yang X, Worley PF, Mattson MP, Gorospe M. hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies. Nat Struct Mol Biol. 2010; (6):732-739.


17.Kuwano Y, Pullmann R, Marasa M, Abdelmohsen K, Lee EK, Yang XL, Martindale J, Zhan M, Gorospe M. NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif. Nucleic Acids Res. 2010;38(1):225-238.


18.Yamamoto Y, Tanahashi T, Kawai T, Chikahisa S, Katsuura S, Nishida K, Teshima-Kondo S, Sei H, Rokutan K. Changes in behavior and gene expression induced by caloric restriction in C57BL/6 mice. Physiological Genomics. 2009; 39(3):227-235.


19.Kim HH, Kuwano Y, Srikantan S, Lee EK, Martindale JL, Gorospe M. HuR recruits let-7/RISC to repress c-Myc expression.Genes Dev. 2009;23(15):1743-1748.


20.Kamizato M, Nishida K, Masuda K, Takeo K, Yamamoto Y, Kawai T, Teshima-Kondo S, Tanahashi T, Rokutan K. Interleukin 10 inhibits interferon gamma- and tumor necrosis factor alpha-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon. J Gastroenterol. 2009;44(12):1172-1184.


21.Takeo K, Kawai T, Nishida K, Masuda K, Teshima-Kondo S, Tanahashi T, Rokutan K. Oxidative stress-induced alternative splicing of transformer 2beta (SFRS10) and CD44 pre-mRNAs in gastric epithelial cells. Am J Physiol Cell Physiol. 2009;297(2):C330-338.


22.Nishida K, Kamizato M, Kawai T, Masuda K, Takeo K, Teshima-Kondo S, Tanahashi T, Rokutan K. Interleukin-18 is a crucial determinant of vulnerability of the mouse rectum to psychosocial stress. FASEB J. 2009;23(6):1797-1805.


23.Dakeshita S, Kawai T, Uemura H, Hiyoshi M, Oguma E, Horiguchi H, Kayama F, Aoshima K,Shirahama S, Rokutan K, Kokichi Arisawa K. Gene expression signatures in peripheral blood from Japanese women exposed to chronic low level of cadmium. Toxicology. 2009;257 (1-2):25-32.


24.Kuwano Y, Tominaga K, Kawahara T, Sasaki H, Takeo K, Nishida K, Kawai T, Teshima-Kondo S, Kazuhito Rokutan. Tumor necrosis factor a activates transcription of NADPH oxidase organizer 1 (NOXO1) gene and up-regulates superoxide production in colon epithelial cells. Free Radic Biol Med. 2008;45(12):1642-1652.


25.Chikahisa S, Tominaga K, Kawai T, Kitaoka K, Oishi K, Ishida N, Rokutan K, Séi H. Bezafibrate, a peroxisome proliferator-activated receptors agonist, decreases body temperature and enhances electroencephalogram delta-oscillation during sleep in mice. Endocrinology. 2008;149(10):5262-5271.


26.Kanemura H, Kusmoto K, Miyake H, Tashiro S, Rokutan K, Shimada M. Geranylgeranylacetone prevents acute liver damage after massive hepatectomy in rats through suppression of a CXC chemokine GRO1 and induction of heat shock proteins. J Gastrointest Surg. 2009;13(1):66-73.


27.Saiki T, Kawai T, Morita K, Ohta M, Saito T, Rokutan K, Ban N. Identification of Marker Genes for Differential Diagnosis of Chronic Fatigue Syndrome. Mol Med. 2008;14(9-10):599-607.


28.Rokutan K, Kawahara T, Kuwano Y, Tominaga K, Nishida K, Teshima-Kondo S. Nox enzymes and oxidative stress in the immunopathology of the gastrointestinal tract. Semin Immunopathol. 2008;30(3):315-27.


29.Masuda K, Teshima-Kondo S, Mukaijo M, Yamagishi N, Nishikawa Y, Nishida K, Kawai T, Rokutan K. A novel tumor-promoting function residing in the 5’ non-coding region of vascular endothelial growth factor mRNA. PLoS Med. 2008;5(5):e94.


30.Brennan SE, Kuwano Y, Alkharouf N, Blackshear PJ, Gorospe M, Wilson GM. The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis.Cancer Res. 2009;69(12):5168-5176.


31.Sasaki H; Yamamoto H, Tominaga K, Masuda K, Kawai T, Teshima-Kondo S, Matsuno K, Yabe-Nishimura C, Rokutan K. Receptor activator of nuclear factor-kB ligand-induced mouse osteoclast differentiation is associated with switching between NADPH oxidase homologues. Free Radic Biol Med. 2009;47(2):189-199.


32.Kawai T, Morita K, Masuda K, Nishida K, Shikishima M, Ohta M, Saito T, Rokutan K. Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress. Biol Psychol. 2007;76(3):147-155.


33.Tominaga K, Kawahara T, Sano T, Toida K, Kuwano Y, Sasaki H, Kawai T, Teshima-Kondo S, Rokutan K. Evidence for cancer-associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach. Free Radic. Biol. Med. 2007;43:1627-1638.


34.Iga J, Ueno S, Yamauchi K, Numata S, Motoki I, Tayoshi S, Kinouchi S, Ohta K, Song H, Morita K, Rokutan K, Tanaba H, Sano A, Ohmori T. Gene expression and association analysis of LIM (PDLIM5) in major depression. Neurosci Lett. 2006;400(3):203-207.


35.Sekiyama A, Ueda H, Kashiwamura S, Nishida K, Yamaguchi S, Sasaki H, Kuwano Y, Rokutan K, Okamura H. A role of the adrenal gland in stress-induced up-regulation of cytokines in plasma. J Neuroimmunol. 2006;171(1-2):38-44.


36.Kuwano Y, Kawahara T, Yamamoto H, Teshima-Kondo S, Tominaga K, Masuda K, Kishi K, Morita K, Rokutan K. Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells. Am J Physiol Cell Physiol. 2006;290(2):C433-C443.


37.Iga J, Ueno S, Yamauchi K, Motoki I, Tayoshi S, Ohta K, Song H, Morita K, Rokutan K, Ohmori T. Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine. Neurosci Lett. 2005;389(1):12-16.


38.Sekiyama A, Ueda H, Kashiwamura S, Sekiyama R, Takeda M, Rokutan K, Okamura H. A stress-induced, superoxide-mediated caspase-1 activation pathway causes plasma IL-18 upregulation. Immunity. 2005; 22(6):669-677.


39.Morita K, Saito T, Ohta M, Ohmori T, Kawai K, Teshima-Kondo S, Rokutan K. Expression analysis of psychological stress-associated genes in peripheral blood leukocytes. Neurosci Lett. 2005;381(1-2):57-62.


40.Ago T, Kitazono T, Kuroda J, Kumai Y, Kamouchi M, Ooboshi H, Wakisaka M, Kawahara T, Rokutan K, Ibayashi S, Iida M. NAD(P)H oxidases in rat basilar arterial endothelial cells. Stroke.2005;36(5):1040-1046.


41.Fukuyama M, Rokutan K, Sano T, Miyake H, Shimada M, Tashiro S. Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon. Cancer Lett. 2005;221(1):97-104.


42.Kawahara T, Kohjima M, Kuwano Y, Mino H, Teshima-Kondo S, Takeya R, Tsunawaki S, Wada A, Sumimoto H, Rokutan K. Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells. Am J Physiol Cell Physiol. 2005;288(2):C450-457.


43.Kusumoto K, Kawahara T, Kuwano Y, Teshima-Kondo S, Morita K, Kishi K, Rokutan K. Ecabet sodium inhibits Helicobacter pylori lipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol. 2005;288(2):G300-307.


44.Teshima-Kondo S, Kondo K, Prado-Lourenco L, Gonzalez-Herrera I, Rokutan K, Bayard F, Arnal JF, Prats AC. Hypergylcemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site. FASEB J. 2004;18(13):1583-1585.


45.Chamulitrat W, Stremmel W, Kawahara T, Rokutan K, Fujii H, Wingler K, Schmidt HH, Schmidt R. A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes. J Invest Dermatol. 2004;122:1000-1009.


46.Kawahara T, Kuwano Y, Teshima-Kondo S, Takeya R, Sumimoto H, Kishi K, Tsunawaki S, Hirayama T, Rokutan K. Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells. J Immunol. 2004;172:3051-3058.


47.Chamulitrat W, Schmidt R, Tomakidi P, Stremmel W, Chunglok W, Kawahara T, Rokutan K. Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes. Oncogene 2003;22:6045-6053.