発表論文

主要発表論文

 

1. Nishijima H, Kajimoto T, Matsuoka Y, et al. Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE). J. Autoimmun. , 2017.

 

2. Matsumoto M. Switching on the Aire conditionerEur. J. Immunol. 45: 3237-3240, 2015.

 

3. Kawano H, Nishijima H, Morimoto J, et al. Aire Expression Is Inherent to Most Medullary Thymic Epithelial Cells during Their Differentiation Program. J. Immunol. 195: 5149-5158, 2015.

 

4. Nishijima H, Kitano S, Miyachi H, et al. Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla. J Immunol. 195: 4641-4649, 2015.

 

5. Mouri Y, Nishijima H, Kawano H, et al. NIK in thymic stroma establishes central tolerance by orchestrating cross-talk with not only thymocytes but also dendritic cells. J. Immunol. 193: 4356-4367, 2014.

 

6. Nishikawa Y, Nishijima H, Matsumoto M, et al. Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program. J. Immunol. 192: 2585-2592, 2014.

 

7. Matsumoto M, Nishikawa Y, Nishijima H, et al. Which model better fits the role of Aire in the establishment of self-tolerance: the transcription model or the maturation model (Review)? Front. Immunol. 4: Article number 210, 2013.

 

8. Mouri Y, Yano M, Shinzawa M, et al. Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. J. Immunol. 186: 5047-5057, 2011.

 

9. Matsumoto M. Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla (Review). Eur. J. Immunol. 41: 12-17, 2011.

 

10. Nishikawa Y, Hirota F, Yano M, et al. Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J. Exp. Med. 207: 963-971, 2010.

 

11. Matsumoto M. The role of autoimmune regulator (Aire) in the development of the immune system (Review). Microbes Infect. 11: 928-934, 2009.

 

12. Yano M, Kuroda N, Han H, et al. Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J. Exp. Med. 205: 2827-2838, 2008.

 

13. Matsumoto M, Zhou Y, Matsuo S, et al. Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology. Proc. Natl. Acad. Sci. USA 105: 6720-6724, 2008.

 

14. Matsumoto M. Transcriptional regulation in thymic epithelial cells for the establishment of self tolerance (Review). Arch. Immunol. Ther. Exp. 55: 27-34, 2007.

 

15. Niki S, Oshikawa K, Mouri Y, et al. Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J. Clin. Invest. 116: 1292-1301, 2006.

 

16. Kinoshita D, Hirota F, Kaisho T, et al. Essential role of IκB kinase α in thymic organogenesis required for the establishment of self-tolerance. J. Immunol. 176: 3995-4002, 2006.

 

17. Kuroda N, Mitani T, Takeda N, et al. Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J.Immunol. 174: 1862-1870, 2005.

 

18. Akiyoshi H, Hatakeyama S, Pitkanen J, et al. Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner. J. Biol. Chem. 279: 33984-33991, 2004.

 

19. Kajiura F, Sun S, Nomura T, et al. NF-κB-inducing kinase establishes self-tolerance in a thymic stroma dependent manner. J. Immunol. 172:2067-2075, 2004.

 

20. Uchida D, Hatakeyama S, Matsushima A, et al. AIRE functions as an E3 ubiquitin ligase. J. Exp. Med. 199:167-172, 2004.

 

21. Matsumoto M, Yamada T, Yoshinaga SK, et al. Essential role of NF-κB-inducing kinase in T cell activation through the TCR/CD3 pathway. J. Immunol. 169:1151-1158, 2002.

 

22. Matsushima A, Kaisho T, Rennert PD, et al. Essential role of NF-κB-inducing kinase and IκB-kinase α in NF-κB activation through lymphotoxin-β receptor, but not though TNF receptor-I. J. Exp. Med. 193:631-636, 2001.

 

23. Yamada T, Mitani T, Yorita K, et al. Abnormal immune function of homopoietic cells from alymphoplasia (aly) mice, natural strain with mutant NF-κB-inducing kinase. J. Immunol. 165:804-812, 2000.

 

24. Matsumoto M, Iwamasa K, Rennert PD, et al. Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-α-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis. J. Immunol. 163:1584-1591, 1999.

 

25. Matsumoto M, Fu Y-X, Molina H, et al. Distinct roles of lymphotoxin-α and the type I TNF receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells. J. Exp. Med. 186: 1997-2004, 1997.

 

26. Matsumoto M, Fukuda W, Circolo A, et al. Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Proc. Natl. Acad. Sci. USA 94: 8720-8725, 1997.

 

27. Matsumoto M, Fu Y-X, Molina H, et al. Lymphotoxin-α deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers. Immunol. Rev. 156: 137-144, 1997.

 

28. Matsumoto M, Lo SF, Carruthers CJL, et al. Affinity maturation without germinal centres in lymphotoxin-α-deficient mice. Nature 382: 462-466, 1996.

 

29. Matsumoto M, Mariathasan S, Nahm MH, et al. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 271: 1289-1291, 1996.

 

共同研究論文を含む全論文

Original Article

2016年

1. Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator
J. Exp. Med. 213:1441-1458, 2016. doi: 10.1084/jem.20151780.

 

2015年

1. Hiroshi Kawano, Hitoshi Nishijima, Junko Morimoto, Fumiko Hirota, Ryoko Morita, Yasuhiro Mouri, Yasuhiko Nishioka, and Mitsuru Matsumoto
Aire expression is inherent to most medullary thymic epithelial cells during their differentiation program.
J. Immunol. 195: 5149-5158, 2015. doi: 10.4049/jimmunol.1501000

 

2. Hitoshi Nishijima, Satsuki Kitano, Hitoshi Miyachi, Junko Morimoto, Hiroshi Kawano, Fumiko Hirota, Ryoko Morita, Yasuhiro Mouri, Kiyoshi Masuda, Issei Imoto, Koichi Ikuta, and Mitsuru Matsumoto
Ectopic Aire expression in the thymic cortex reveals inherent properties of Aire as a tolerogenic factor within the medulla.
J. Immunol. 195: 4641-4649, 2015. doi: 10.4049/jimmunol.1501026

 

2014年

1. Yumiko Nishikawa, Hitoshi Nishijima, Minoru Matsumoto, Junko Morimoto, Fumiko Hirota, Satoru Takahashi, Hervé Luche, Hans Joerg Fehling, Yasuhiro Mouri, and Mitsuru Matsumoto
Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.
J. Immunol. 192: 2585-2592, 2014. doi: 10.4049/jimmunol.1302786

 

2. Yasuhiro Mouri, Hitoshi Nishijima, Hiroshi Kawano, Fumiko Hirota, Nobuo Sakaguchi, Junko Morimoto, and Mitsuru Matsumoto
NIK in thymic stroma establishes central tolerance by orchestrating cross-talk with not only thymocytes but also dendritic cells.
J. Immunol. 193: 4356-4367, 2014. doi: 10.4049/jimmunol.1400389

 

2013年

1. Nakaya, M., Tajima, M., Kosako, H., Nakaya, T., Hashimoto, A., Watari, K., Nishihara, H., Ohba, M., Komiya, S., Tani, N., Nishida, M., Taniguchi, H., Sato, Y., Matsumoto, M., Tsuda, M., Kuroda, M., Inoue, K., and Kurose, H.
GRK6-deficient mice exhibit reduced recycling of senescent red blood cells and impaired apoptotic cell clearance causing autoimmunity.
Nat. Commun. 4: Article number 1532, 2013. doi:10.1038/ncomms2540

    Published 26 Feb 2013

   

2. Yoshida, S., Aihara, K., Ikeda, Y., Sumitomo-Ueda, Y., Uemoto, R., Ishikawa, K., Ise, T., Yagi, S., Iwase, T., Mouri, Y., Sakari, M., Matsumoto, T., Takeyama, K., Akaike, M., Matsumoto, M., Sata, M., Walsh, K., Kato, K., and Matsumoto, T.
Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling.
Circulation 128: 60-71, 2013. DOI: 10.1161/CIRCULATIONAHA.113.001533

 

3. Odaka, C., Hauri-Hohl, M., Takizawa, K., Nishikawa, Y., Yano, M., Matsumoto, M., Boyd, R., and Holländer, G.A.
TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall’s corpuscles in mice.
Int. Immunol. 25: 633-642, 2013. doi:10.1093/intimm/dxt026

 

2012年

1. Yukiko Kuroda, Wataru Sako, Satoshi Goto, Tomoyo Sawada, Daisuke Uchida, Yuishin Izumi, Tetsuya Takahashi, Noriko Kagawa, Masayasu Matsumoto, Mitsuru Matsumoto, Ryosuke Takahashi, Ryuji Kaji, and Takao Mitsui.
Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential.
Hum. Mol. Genet. 21: 991-1003, 2012.

 

2. Ueda, Y., Katagiri, K., Tomiyama, T., Yasuda, K., Habiro, K., Katakai, T., Ikehara, S., Matsumoto, M., and Kinashi, T.
Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus.
Nat. Commun. 3: Article number 1098, 2012.

 

3. Sakane, A., Abdallah, A.A.M., Nakano, K., Honda, K., Ikeda, W., Nishikawa, Y., Matsumoto, M., Matsushita, N., Kitamura, T., and Sasaki, T.
Rab13 small G protein and Junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial junctional development.
J. Biol. Chem. 287: 42455-42468, 2012.

  

2011年

1. Yasuhiro Mouri, Masashi Yano, Miho Shinzawa, Yusuke Shimo, Fumiko Hirota, Yumiko Nishikawa, Takuro Nii, Hiroshi Kiyonari, Takaya Abe, Hisanori Uehara, Keisuke Izumi, Koji Tamada, Lieping Chen, Josef M. Penninger, Jun-ichiro Inoue, Taishin Akiyama and Mitsuru Matsumoto.
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.
J. Immunol. 186: 5047-5057, 2011.

 

2. Ryutaro Fukui, Shin-Ichiroh Saitoh, Atsuo Kanno, Masahiro Onji, Takuma Shibata, Akihiko Ito, Morikazu Onji, Mitsuru Matsumoto, Shizuo Akira, Nobuaki Yoshida and Kensuke Miyake.
Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.
Immunity 35: 69-81, 2011.

 

3. Naoko Wada, Koji Nishifuji, Taketo Yamada, Jun Kudoh, Nobuyoshi Shimizu, Mitsuru Matsumoto, Leena Peltonen, Seiho Nagafuchi and Masayuki Amagai.
Aire-dependent thymic expression of desmoglein 3, the autoantigen in pemphigus vulgaris, and its role in T-cell tolerance.
J. Invest. Dermatol. 131: 410-417, 2011.

 

2010年

1. Yumiko Nishikawa, Fumiko Hirota, Masashi Yano, Hiroyuki Kitajima, Jun-ichi Miyazaki, Hiroshi Kawamoto, Yasuhiro Mouri and Mitsuru Matsumoto.
Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation.
J. Exp. Med. 207: 963-971, 2010.

 

2. Yuka Tomoe, Hiroko Segawa, Kazuyo Shiozawa, Ichiro Kaneko, Rieko Tominaga, Etsuyo Hanabusa, Fumito Aranami, Junya Furutani, Shoji Kuwahara, Sawako Tatsumi, Mitsuru Matsumoto, Mikiko Ito and Ken-ichi Miyamoto.
Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice.
Am. J. Physiol. Renal Physiol. 297: F1341-1350, 2010.

 

2009年

1. Kimi Yamakoshi, Akiko Takahashi, Fumiko Hirota, Rika Nakayama, Naozumi Ishimaru, Yoshiaki Kubo, David J. Mann, Masako Ohmura, Atsushi Hirao, Hideyuki Saya, Seiji Arase, Yoshio Hayashi, Kazuki Nakao, Mitsuru Matsumoto, Naoko Ohtani and Eiji Hara.
Real-time in vivo imaging of p16Ink4a reveals cross-talk with p53.
J. Cell Biol. 186: 393-407, 2009.

 

2. Hiroko Segawa, Akemi Onitsuka, Junya Furutani, Ichiro Kaneko, Fumito Aranami, Natsuki Matsumoto, Yuka Tomoe, Masashi Kuwahata, Mikiko Ito, Mitsuru Matsumoto, Minqi Li, Norio Amizuka and Ken-ichi Miyamoto.
Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development.
Am. J. Physiol. Renal Physiol. 297: F671-678, 2009.

 

3. Hiroko Segawa, Akemi Onitsuka, Masashi Kuwahata, Etsuyo Hanabusa, Junya Furutani, Ichiro Kaneko, Yuka Tomoe, Fumito Aranami, Natsuki Matsumoto, Mikiko Ito, Mitsuru Matsumoto, Minqi Li, Norio Amizuka and Ken-ichi Miyamoto.
Type IIc sodium–dependent phosphate transporter regulates calcium metabolism.
J. Am. Soc. Nephrol. 20: 104-113, 2009.

 

2008年

1. Masashi Yano, Noriyuki Kuroda, Hongwei Han, Makiko Horike, Yumiko Nishikawa, Hiroshi Kiyonari, Kentaro Maemura, Yuchio Yanagawa, Kunihiko Obata, Satoru Takahashi, Tomokatsu Ikawa, Rumi Satoh, Hiroshi Kawamoto, Yasuhiro Mouri and Mitsuru Matsumoto.
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance.
J. Exp. Med. 205: 2827-2838, 2008.

 

2. Mitsuru Matsumoto, Yiqing Zhou, Shinji Matsuo, Hideki Nakanishi, Kenji Hirose, Hajimu Oura, Seiji Arase, Akemi Ishida-Yamamoto, Yoshimi Bando, Keisuke Izumi, Hiroshi Kiyonari, Naoko Oshima, Rika Nakayama, Akemi Matsushima, Fumiko Hirota, Yasuhiro Mouri, Noriyuki Kuroda, Shigetoshi Sano and David D. Chaplin.
Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology.
Proc. Natl. Acad. Sci. USA. 105: 6720-6724, 2008.

 

3. Taishin Akiyama, Yusuke Shimo, Hiromi Yanai, Junwen Qin, Daisuke Ohshima, Yuya Maruyama, Yukiko Asaumi, Juli Kitazawa, Hiroshi Takayanagi, Josef Penninger, Mitsuru Matsumoto, Takeshi Nitta, Yousuke Takahama and Jun-ichiro Inoue.
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Immunity 29: 423-437, 2008.

 

4. Yu Hikosaka, Takeshi Nitta, Izumi Ohigashi, Kouta Yano, Naozumi Ishimaru, Yoshio Hayashi, Mitsuru Matsumoto, Koichi Matsuo, Josef M Penninger, Hiroshi Takayanagi, Yoshifumi Yokota, Hisakata Yamada, Yasunobu Yoshikai, Jun-ichiro Inoue, Taishin Akiyama and Yousuke Takahama.
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Immunity 29: 438-450, 2008.

 

5. Masashi Nakatani, Yuka Takehara, Hiromu Sugino, Mitsuru Matsumoto, Osamu Hashimoto, Yoshihisa Hasegawa, Tatsuya Murakami, Akiyoshi Uezumi, Shin'ichi Takeda, Sumihare Noji, Yoshihide Sunada and Kunihiro Tsuchida.
Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice.
FASEB Journal 22: 477-487, 2008.

 

2007年

1. Yoko Hamazaki, Harumi Fujita, Takashi Kobayashi, Yongwon Choi, Hamish S Scott, Mitsuru Matsumoto and Nagahiro Minato.
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin.
Nature Immunol. 8: 304-311, 2007.

 

2. Naoko Ohtani, Yuko Imamura, Kimi Yamakoshi, Fumiko Hirota, Rika Nakayama, Yoshiaki Kubo, Naozumi Ishimaru, Akiko Takahashi, Atsushi Hirota, Takatsune Shimizu, David J. Mann, Hideyuki Saya, Yoshio Hayashi, Seiji Arase, Mitsuru Matsumoto, Kazuki Nakao and Eiji Hara.
Visualizing the dynamics of p21 (Wafl/Cip1)cyclin-dependent kinase inhibitor expression in living animals.
Proc. Natl. Acad. Sci. USA. 104: 15034-15039, 2007.

 

3. Toshiyuki Obata, Ichiro Yokota, Kazuhiro Yokoyama, Eiji Okamoto, Yoshiko Kanezaki, Yoshinori Tanaka, Hiroshi Maegawa, Kiyoshi Teshigawara, Fumiko Hirota, Tomoyuki Yuasa, Kazuhiro Kishi, Atsushi Hattori, Seiichi Hashida, Kazuhiko Masuda, Mitsuru Matsumoto, Toshio Matsumoto, Atsunori Kashiwagi and Yousuke Ebina.
Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes mellitus.
Diabetes 56: 2028-2035, 2007.

 

4. Junwen Qin, Hiroyasu Konno, Daisuke Ohshima, Hiromi Yanai, Hidehiko Motegi, Yusuke Shimo, Fumiko Hirota, Mitsuru Matsumoto, Satoshi Takaki, Jun-ichiro Inoue and Taishin Akiyama.
Developmental stage-dependent collaboration between the TNF receptor-associated factor 6 and lymphotoxin pathways for B cell follicle organization in secondary lymphoid organs.
J. Immunol. 179: 6799-6807, 2007.

 

2006年

1. Shino Niki, Kiyotaka Oshikawa, Yasuhiro Mouri, Fumiko Hirota, Akemi Matsushima, Masashi Yano, Hongwei Han, Yoshimi Bando, Keisuke Izumi, Masaki Matsumoto, Keiichi I. Nakayama, Noriyuki Kuroda and Mitsuru Matsumoto.
Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice.
J. Clin. Invest. 116: 1292-1301, 2006.

 

2. Dan Kinoshita, Fumiko Hirota, Tsuneyasu Kaisho, Michiyuki Kasai, Keisuke Izumi, Yoshimi Bando, Yasuhiro Mouri, Akemi Matsushima, Shino Niki, Hongwei Han, Kiyotaka Oshikawa, Noriyuki Kuroda, Masahiko Maegawa, Minoru Irahara, Kiyoshi Takeda, Shizuo Akira and Mitsuru Matsumoto.
Essential role of IkB kinase a in thymic organogenesis required for the establishment of self-tolerance.
J. Immunol. 176: 3995-4002, 2006.

 

3. Katsuaki Hoshino, Takahiro Sugiyama, Mitsuru Matsumoto, Takashi Tanaka, Masuyoshi Saito, Hiroaki Hemmi, Osamu Ohara, Shizuo Akira and Tsuneyasu Kaisho.
IκB kinase-α is critical for interferon-a production induced by Toll-like receptors 7 and 9.
Nature 440: 949-953, 2006

 

2005年

1. Noriyuki Kuroda, Tasuku Mitani, Naoki Takeda, Naozumi Ishimaru, Rieko Arakaki, Yoshio Hayashi, Yoshimi Bando, Keisuke Izumi, Takeshi Takahashi, Takashi Nomura, Shimon Sakaguchi, Tomoo Ueno, Yousuke Takahama, Daisuke Uchida, Shijie Sun, Fumiko Kajiura, Yasuhiro Mouri, Hongwei Han, Akemi Matsushima, Gen Yamada and Mitsuru Matsumoto.
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice.
J. Immunol. 174: 1862-1870, 2005.

 

2. Taishin Akiyam, Shiori Maeda, Sayaka Yamane, Kaori Ogino, Michiyuki Kasai, Fumiko Kajiura, Mitsuru Matsumoto and Jun-ichiro Inoue.
Dependence of self-tolerance on TRAF6-directed development of thymic stroma.
Science 308: 248-251, 2005.

 

3. Yoshinori Nagai, Toshihiko Kobayashi, Yuji Motoi, Kohtaroh Ishiguro, Sachiko Akashi, Shin-ichiroh Saitoh, Yutaka Kusumoto, Tsuneyasu Kaisho, Shizuo Akira, Mitsuru Matsumoto, Kiyoshi Takatsu and Kensuke Miyake.
The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.
J. Immunol. 174: 7043-7049, 2005.

 

2004年

1. Daisuke Uchida, Shigetsugu Hatakeyama, Akemi Matsushima, Hongwei Han, Satoshi Ishido, Hak Hotta, Jun Kudoh, Nobuyuki Shimizu, Vassilis Doucas, Keiichi I Nakayama, Noriyuki Kuroda and Mitsuru Matsumoto.
AIRE functions as an E3 ubiquitin ligase.
J. Exp. Med. 199: 166-172, 2004.

 

2. Fumiko Kajiura, Shijie Sun, Takashi Nomura, Keisuke Izumi, Tomoo Ueno, Yoshimi Bando, Noriyuki Kuroda, Hongwei Han, Yi Li, Akemi Matsushima, Yousuke Takahama, Shimon Sakaguchi, Tasuku Mitani and Mitsuru Matsumoto.
NF-kB-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.
J. Immunol. 172: 2067-2075, 2004.

 

3. Tomoyuki Yuasa, Rei Kakuhata, Kazuhiro Kishi, Toshiyuki Obata, Yasuo Shinohara, Yoshimi Bando, Keisuke Izumi, Fumiko Kajiura, Mitsuru Matsumoto and Yousuke Ebina.
Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect blood glucose levels.
Diabetes 53: 2776-2786, 2004.

 

4. Hiroko Akiyoshi, Shigetsugu Hatakeyama, Jukka Pitkanen, Yasuhiro Mouri, Vassilis Doucas, Jun Kudoh, Kyoko Tsurugaya, Daisuke Uchida, Akemi Matsushima, Kiyotaka Oshikawa, Keiichi I. Nakayama, Nobuyoshi Shimizu, Part Peterson and Mitsuru Matsumoto.
Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner.
J. Biol. Chem. 279: 33984-33991, 2004.

 

5. Takashi Sakai, Li Liu, Xichuan Teng, Rika Mukai-Sakai, Hidenori Shimada, Ryuji Kaji, Tasuku Mitani, Mitsuru Matsumoto, Kazunori Toida, Kazunori Ishimura, Yuji Shishido, Tak W. Mak and Kiyoshi Fukui.Nucling Recruits Apaf-1/Pro-caspase-9 complex for the induction of stress-induced apoptosis.
J. Biol. Chem. 279: 41131-41140, 2004.

 

6. Yoshiko Kanezaki, Toshiyuki Obata, Rie Matsushima, Asako Minami, Tomoyuki Yuasa, Kazuhiro Kishi, Yoshimi Bando, Hisanori Uehara, Keisuke Izumi, Tasuku Mitani, Mitsuru Matsumoto, Yukari Takeshita, Yutaka Nakaya, Toshio Matsumoto and Yousuke Ebina.
KATP channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes.
Endocrine J. 51: 133-144, 2004.

 

2003年

1. Asako Minami, Masanori Iseki, Kazuhiro Kishi, Miao Wang, Makoto Ogura, Noboru Furukawa, Sanae Hayashi, Mizuki Yamada, Toshiyuki Obata, Yukari Takeshita, Yutaka Nakaya, Yoshimi Bando, Keisuke Izumi, Shonna A Moodie, Fumiko Kajiura, Mitsuru Matsumoto, Kiyoshi Takatsu, Satoshi Takaki and Yousuke Ebina.
Increased insulin sensitivity and hypoinsulinemia in APS knockout mice.
Diabetes 52: 2657-2665, 2003.

 

2002年

1. Mitsuru Matsumoto, Takuji Yamada, Steven K. Yoshinaga, Tom Boone, Tom Horan, Shigeru Fujita, Yi Li and Tasuku Mitani.
Essential role of NF-kB-inducing kinase in T cell activation through the TCR/CD3 pathway.
J. Immunol. 169: 1151-1158, 2002.

 

2001年

1. Akemi Matsushima, Tsuneyasu Kaisho, Paul D. Rennert, Hiroyasu Nakano, Kyoko Kurosawa, Daisuke Uchida, Kiyoshi Takeda, Shizuo Akira and Mitsuru Matsumoto.
Essential role of NF-kB-inducing kinase and IkB-kinase a in NF-kB activation through lymphotoxin-b receptor, but not through TNF receptor-I.
J. Exp. Med. 193: 631-636, 2001.

 

2000年

1. Takuji Yamada, Tasuku Mitani, Kazuko Yorita, Daisuke Uchida, Akemi Matsushima, Kikue Iwamasa, Shigeru Fujita and Mitsuru Matsumoto.
Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kB-inducing kinase.
J. Immunol. 165: 804-812, 2000.

 

2. Masaya Uwai, Yasuhito Terui, Yuji Mishima, Hiroshi Tomizuka, Masayuki Ikeda, Takehito Itoh, Masaki Mori, Masuzu Ueda, Rie Inoue, Muneo Yamada, Hirotoshi Hayasawa, Takahiko Horiuchi, Yoshiyuki Niho, Mitsuru Matsumoto, Yukihito Ishizaka, Kazuma Ikeda, Keiya Ozawa and Kiyohiko Hatake.
A new apoptotic pathway for the complement factor B-derived fragment Bb.
J. Cell. Physiol. 185: 280-292, 2000.

 

1999年

1. Mitsuru Matsumoto, Kikue Iwamasa, Paul D. Rennert, Takuji Yamada, Rika Suzuki, Akemi Matsushima, Masaru Okabe, Shigeru Fujita and Minesuke Yokoyama.
Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-a-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis.
J. Immunol. 163: 1584-1591, 1999.

 

2. Hiroyasu Nakano, Sachiko Sakon, Haruhiko Koseki, Toshitada Takemori, Kurisu Tada, Mitsuru Matsumoto, Eiko Munechika, Tsuyoshi Sasaki, Takuji Shirasawa, Hisaya Akiba, Tetsuji Kobata, Sybil M. Santee, Carl F. Ware, Paul D. Rennert, Masaru Taniguchi, Hideo Yagita and Ko Okumura.
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation.
Proc. Natl. Acad. Sci. USA. 96: 9803-9808, 1999.

 

1998年

1. Watanabe I, Horiuchi T, Hatta N, Matsumoto M, Koike K, Kojima S, Ohga S and Fujita S.
Analysis of neurofibromatosis type 1 gene mutation in juvenile chronic myelogenous leukemia.
Acta Haematol. 100: 22-25, 1998.

 

1997年

1. Mitsuru Matsumoto, Yang-Xin Fu, Hector Molina, Guangming Huang, Jinho Kim, Dori A. Thomas, Moon H. Nahm and David D. Chaplin.
Distinct roles of lymphotoxin-a and the type I TNF receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells.
J. Exp. Med. 186: 1997-2004, 1997.

 

2. Mitsuru Matsumoto, Wataru Fukuda, Antonella Circolo, Joseph Goellner, Jena Strauss-Schoenberger, Xuefeng Wang, Shigeru Fujita, Tunde Hidvegi, David D Chaplin and Harvey R Colten.
Abrogation of the alternative complement pathway by targeted deletion of murine factor B.
Proc. Natl. Acad. Sci. USA. 94: 8720-8725, 1997.

 

3. Yang-Xin Fu, Hector Molina, Mitsuru Matsumoto, Guangming Huang, Jingjuan Min and David D Chaplin.
Lymphotoxin-a (LTa) supports development of splenic follicular structure that is required for IgG responses.
J. Exp. Med. 185: 2111-2120, 1997.

 

4. Yang-Xin Fu, Guangming Huang, Mitsuru Matsumoto, Hector Molina and David D Chaplin.
Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node.
Proc. Natl. Acad. Sci. USA. 94: 5739--5743, 1997.

 

1996年

1. Mitsuru Matsumoto, Stanley F Lo, Cynthia JL Carruthers, Jingjuan Min, Sanjeev Mariathasan, Guangming Huang, David R Plas, Steven M Martin, Raif S Geha, Moon H Nahm and David D Chaplin.
Affinity maturation without germinal centres in lymphotoxin-a-deficient mice.
Nature 382: 462-466, 1996.

 

2. Mitsuru Matsumoto, Sanjeev Mariathasan, Moon H Nahm, Ferenc Baranyay, Jacques J Peschon and David D Chaplin.
Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers.
Science 271: 1289-1291, 1996.

 

3. Mitsuru Matsumoto, Yoshiki Tange, Takanori Okada, Yasuhiro Inoue, Takahiko Horiuchi, Yuzuru Kobayashi and Shigeru Fujita.
Deletion in the 190 kDa antigen gene repeat region of Rickettsia rickettsia.
Microb. Pathog. 20: 57-62, 1996.

 

1995年

1. Sanjeev Mariathasan, Mitsuru Matsumoto, Ferenc Baranyay, Moon M Nahm, Osami Kanagawa and David D Chaplin.
Absence of lymph nodes in lymphotoxin-a (LTa)-deficient mice is due to abnormal organ development, not defective lymphocyte migration.
J. Inflamm. 45: 72-78, 1995.

 

1994年

1. Matsumoto M, Takada K, Hato T, Horiuchi T, Yasukawa M, Murao S and Fujita S.
Monoclonal proliferation of double-negative (CD4-CD8-) T-cells bearing T-cell receptor-ab followed by subsequent development of Hodgkin's disease.
Cancer 73: 2818-2823, 1994.

 

2. Matsubara A, Matsumoto M, Takada K, Hato T, Hasegawa H, Tamai T, Yasukawa M and Fujita S.
Acute transformation of chronic large granular lymphocyte leukemia into an aggressive form associated with preferential organ involvement.
Acta Haematol. 91: 206-210, 1994.

 

3. Horiuchi T, Hatta N, Matsumoto M, Ohtsuka H, Collins FS, Kobayashi Y and Fujita S.
Nonsense mutations at Arg-1947 in two cases of familial neurofibromatosis type 1 in Japanese.
Hum. Genet. 93: 81-83, 1994.

 

4. Tange Y, Matsumoto M, Okada T, Hasegawa H and Kobayashi Y.
Detection of DNA of causative agent of spotted fever group rickettsiosis in Japan from the patient's blood sample by polymerase chain reaction.
Microbiol. Immunol. 38: 665-658, 1994.

 

1993年

1. Horiuchi T, Kim S, Matsumoto M, Watanabe I, Fujita S and Volanakis JE.
Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression.
Mol. Immunol. 30: 1587-1592, 1993.

 

1991年

1. Matsumoto M, Yasukawa M, Inatsuki A and Kobayashi Y.
Human double-negative (CD4-CD8-) T cells bearing ab T cell receptor possess both helper and cytotoxic activities.
Clin. Exp. Immunol. 85: 525-530, 1991.

 

2. Matsumoto M, Takada K, Kameoka H, Hato T, Shiosaka T, Fujita S and Kobayashi Y.
Discrepancy between antiplatelet antibody activities detected by immunoblot procedure and platelet counts in idiopathic thrombocytopenic purpura.
Jpn. J. Med. 30: 10-14, 1991.

 

3. Yasukawa M, Hato T, Matsumoto M, Takada K, Fujita S and Kobayashi Y.
Proliferation of double-negative (CD4-CD8-) T cells bearing T-cell receptor-ab in a haemophiliac with human immunodeficiency virus type 1 infection and factor VIII inhibitor: functional properties of double-negative T-cell receptor-ab+ T cells.
Br. J. Haematol. 79: 372-376, 1991.

 

1989年

1. Matsumoto M, Mochizuki K and Kobayashi Y.
Deoxyribonucleic acid-binding properties of human monoclonal anti-platelet antibodies obtained from patients with idiopathic thrombocytopenic purpura.
Jpn. J. Med. 28: 593-598, 1989.

 

2. Matsumoto M, Mochizuki K and Kobayashi Y.
Productive ascites growth of heterohybridomas between Epstein-Barr virus-transformed human B cells and murine P3X63Ag8.653 myeloma cells.
Microbiol. Immunol. 33: 883-886, 1989.

 

Review Article

1. Mitsuru Matsumoto
Switching on the Aire conditioner.
Eur. J. Immunol. 45: 3237-3240, 2015. DOI: 10.1002/eji.201546098

 

2. Matsumoto, M., Nishikawa, Y., Nishijima, H., Morimoto, J., Matsumoto, M., and Mouri, Y.
Which model better fits the role of Aire in the establishment of self-tolerance: the transcription model or the maturation model?
Front. Immunol. 4: Article number 210, 2013. doi: 10.3389/fimmu.2013.00210

 

3. Mitsuru Matsumoto
Contrasting models for the roles of Aire in the differentiation program of epithelial cells in the thymic medulla.
Eur. J. Immunol. 41: 12-17, 2011.

 

4. Mitsuru Matsumoto
The role of autoimmune regulator (Aire) in the development of the immune system.
Microb. Infect. 11: 928-934, 2009.

 

5. Mitsuru Matsumoto
NF-kB activation pathway in thymic epithelial cells controls establishment of self-tolerance.
Inflamm. Regenerat. 27: 165-170, 2007.

 

6. Mitsuru Matsumoto
Autoimmune regulator functions in autoimmunity control.
Expert Rev. Clin. Immunol. 3: 891-900, 2007.

 

7. Mitsuru Matsumoto
Transcriptional regulation in thymic epithelial cells for the establishment of self tolerance.
Arch. Immunol. Therap. Exp. 55: 27-34, 2007.

 

8. Mitsuru Matsumoto
Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.
J. Med. Invest. 46: 141-150, 1999.

 

9. Mitsuru Matsumoto, Yang-Xin Fu, Hector Molina and David D. Chaplin.
Lymphotoxin-a deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers.
Immunol. Rev. 156: 137-144, 1997.